Difference between revisions of "Talk:Structure-based mutation analysis TSD"
(Created page with "Unfortunately not all data is available yet. With the upcoming pictures for the structures it should be more clear. However even without all data its still very understandable a…") |
Bernhoferm (talk | contribs) |
||
| Line 17: | Line 17: | ||
-[[User:Joerdensv|Joerdensv]] 08:11 26.06.2012 |
-[[User:Joerdensv|Joerdensv]] 08:11 26.06.2012 |
||
| + | |||
| + | |||
| + | Not much to add from my side. As always you did a good job and thorough analysis. I'm looking forward to the finished version. |
||
| + | |||
| + | Just one more thing: In the section for D207E you are talking about a "protein donor". Did you mean "proton donor"? |
||
| + | --[[User:Bernhoferm|Bernhoferm]] 07:44, 26 June 2012 (UTC) |
||
Revision as of 08:44, 26 June 2012
Unfortunately not all data is available yet. With the upcoming pictures for the structures it should be more clear.
However even without all data its still very understandable and very carefully evaluated.
Typos:
Table 1: The parameters are important for choosing the structcture
P182L section: P182 is on the surface of the Hex A alpha subunit and proline act as a helix breaker - i think it should be "acts"
S293I section: serine leads to a clashes with - exception: there are classified clashes as "a"
This would slightly change the protein's surface but should also no affect the binding to the beta subunit. - "not"
Conclusion SCWRL/FoldX: in several ones they do no, - again "not" or is it really possible to say so
-Joerdensv 08:11 26.06.2012
Not much to add from my side. As always you did a good job and thorough analysis. I'm looking forward to the finished version.
Just one more thing: In the section for D207E you are talking about a "protein donor". Did you mean "proton donor"? --Bernhoferm 07:44, 26 June 2012 (UTC)
