Structure-based mutation analysis HEXA
We had to use a PDB file, in which are no missing residues. It was not possible to find one file, without any missing residues. In each file there was a gap between residue 74 to 89 and the last amino acid. Therefore, we decided to cut off the first 89 residues and use a PDB file with a structure from 89 - 528. This file can be found [here].
Because of the shorten PDB file, it was not possible for us to analyse the first two mutations on position 29 and 39.
|SNP-id||codon number||mutation codon||mutation triplet|
|rs4777505||29||Asn -> Ser||AAC -> AGC|
|rs121907979||39||Leu -> Arg||CTT -> CGT|
|rs61731240||179||His -> Asp||CAT -> GAT|
|rs121907974||211||Phe -> Ser||TTC -> TCC|
|rs61747114||248||Leu -> Phe||CTT -> TTT|
|rs1054374||293||Ser -> Ile||AGT -> ATT|
|rs121907967||329||Trp -> TER||TGG -> TAG|
|rs1800430||399||Asn -> Asp||AAC -> GAC|
|rs121907982||436||Ile -> Val||ATA -> GTA|
|rs121907968||485||Trp -> Arg||gTGG -> CGG|
Analysis of the mutations
We created for each mutation an extra page. The summary of the analysis can be seen in the Summary Section.