Difference between revisions of "Sequence-based mutation analysis HEXA/Mutation Summary"

From Bioinformatikpedia
(pysicochemical properities)
(Blanked the page)
 
Line 1: Line 1:
 
=== Visualisation of the mutations ===
 
 
 
{| border="1" style="text-align:center; border-spacing:0;"
 
|SNP-id
 
|mutation codon
 
|picture original aa
 
|picture mutated aa
 
|combined picture
 
|-
 
|rs4777505
 
|Asn -> Ser
 
|[[Image:N29_2.png|thumb|150px|Amino acid Asparagine]]
 
|[[Image:29S_2.png|thumb|150px|Amino acid Serine]]
 
|[[Image:N29S.png|thumb|150px|Picture which visualize the mutation]]
 
|-
 
|rs121907979
 
|Leu -> Arg
 
|[[Image:L39.png|thumb|150px|Amino acid Leucine]]
 
|[[Image:39R.png|thumb|150px|Amino acid Arginine]]
 
|[[Image:L39R.png|thumb|150px|Picture which visualize the mutation]]
 
|-
 
|rs61731240
 
|His -> Asp
 
|[[Image:H179.png|thumb|150px|Amino acid Histidine]]
 
|[[Image:179D.png|thumb|150px|Amino acid Aspartate]]
 
|[[Image:H179D.png|thumb|150px|Picture which visualize the mutation]]
 
|-
 
|rs121907974
 
|Phe -> Ser
 
|[[Image:F211.png|thumb|150px|Amino acid Phenylalanine]]
 
|[[Image:211S.png|thumb|150px|Amino acid Serine]]
 
|[[Image:F211S.png|thumb|150px|Picture which visualize the mutation]]
 
|-
 
|rs61747114
 
|Leu -> Phe
 
|[[Image:L248.png|thumb|150px|Amino acid Leucine]]
 
|[[Image:248W.png|thumb|150px|Amino acid Phenylalanine]]
 
|[[Image:L248W.png|thumb|150px|Picture which visualize the mutation]]
 
|-
 
|rs1054374
 
|Ser -> Ile
 
|[[Image:S293.png|thumb|150px|Amino acid Serine]]
 
|[[Image:293I.png|thumb|150px|Amino acid Isoleucine]]
 
|[[Image:S293I.png|thumb|150px|Picture which visualize the mutation]]
 
|-
 
|rs121907967
 
|Trp -> TER
 
|[[Image:W329.png|thumb|150px|Amino acid Tryptophan]]
 
|
 
|[[Image:prot_ter.png|thumb|150px|Visualization of the mutated protein]]
 
|-
 
|rs1800430
 
|Asn -> Asp
 
|[[Image:N399.png|thumb|150px|Amino acid Asparagine]]
 
|[[Image:399D.png|thumb|150px|Amino acid Aspartic acid]]
 
|[[Image:N399D.png|thumb|150px|Picture which visualize the mutation]]
 
|-
 
|rs121907982
 
|Ile -> Val
 
|[[Image:I436.png|thumb|150px|Amino acid Isoleucine]]
 
|[[Image:436V.png|thumb|150px|Amino acid Valin]]
 
|[[Image:I436V.png|thumb|150px|Picture which visualize the mutation]]
 
|-
 
|rs121907968
 
|Trp -> Arg
 
|[[Image:W485.png|thumb|150px|Amino acid Tryptophan]]
 
|[[Image:485R.png|thumb|150px|Amino acid Arginine]]
 
|[[Image:W485R.png|thumb|150px|Picture which visualize the mutation]]
 
|-
 
|}
 
 
[[http://i12r-studfilesrv.informatik.tu-muenchen.de/wiki/index.php/Sequence-based_mutation_analysis_HEXA#Summary_page Back to Sequence-based mutation analysis]]
 
 
=== Substitutions Matrices ===
 
 
{| border="1" style="text-align:center; border-spacing:0;"
 
|rowspan="2" | SNP-id
 
|rowspan="2" | mutation codon
 
|colspan="3" | PAM 1
 
|colspan="3" | Pam 250
 
|colspan="3" | BLOSOUM 62
 
|-
 
|value aa
 
|most frequent substitution
 
|rarest substitution
 
|value aa
 
|most frequent substitution
 
|rarest substitution
 
|value aa
 
|most frequent substitution
 
|rarest substitution
 
|-
 
|rs4777505
 
|Asn -> Ser
 
|20
 
|36 (Asp)
 
|0 (Cys, Met)
 
|5
 
|7 (Asp)
 
|2 (Cys, Leu, Phe, Trp)
 
|1
 
|1 (Asp, His, Ser)
 
| -4 (Trp)
 
|-
 
|rs121907979
 
|Leu -> Arg
 
|1
 
|22 (Ile)
 
|0 (Asp, Cys)
 
|4
 
|20 (Met)
 
|2 (Cys)
 
| -2
 
|0 (Phe)
 
| -4 (Asp, Gly)
 
|-
 
|rs61731240
 
|His -> Asp
 
|3
 
|20 (Gln)
 
|0 (Ile, Met)
 
|4
 
|7 (Gln)
 
|2 (Ala, Cys, Gly, Ile, Leu, Met, Phe, Thr, Trp, Val)
 
| -1
 
|2 (Tyr)
 
| -3 (Cys, Ile, Leu, Val)
 
|-
 
|rs121907974
 
|Phe -> Ser
 
|2
 
|28 (Tyr)
 
|0 (Asp, Cys, Glu, Lys, Pro, Val)
 
|2
 
|20 (Tyr)
 
|1 (Arg, Asp, Cys, Gln, Glu, Gly, Lys, Pro)
 
| -2
 
|3 (Tyr)
 
| -4 (Pro)
 
|-
 
|rs61747114
 
|Leu -> Phe
 
|13
 
|45 (Met)
 
|0 (Asp, Cys)
 
|13
 
|20 (Met)
 
|2 (Cys)
 
|0
 
|2 (Ile, Met)
 
| -4 (Asp, Gly)
 
|-
 
|rs1054374
 
|Ser -> Ile
 
|2
 
|38 (Thr)
 
|1 (Leu)
 
|5
 
|9 (Ala, Gly, Pro, Thr)
 
|3 (Phe)
 
| -2
 
|1 (Ala, Asn, Thr)
 
| -3 (Trp)
 
|-
 
|rs121907967
 
|Trp -> TER
 
|X
 
|2 (Arg)
 
|0 (all, except Arg, Phe, Ser, Tyr)
 
|X
 
|2 (Arg)
 
|0 (all, except Arg, His, Leu, Phe, Ser, Tyr)
 
|X
 
|2 (Tyr)
 
| -4 (Asn, Asp, Pro)
 
|-
 
|rs1800430
 
|Asn -> Asp
 
|36
 
|36 (Asp)
 
|0 (Cys, Met)
 
|7
 
|7 (Asp)
 
|2 (Cys, Leu, Phe, Trp)
 
|1
 
|1 (Asp, His, Ser)
 
| -4 (Trp)
 
|-
 
|rs121907982
 
|Ile -> Val
 
|33
 
|33 (Val)
 
|0 (Gly, Pro, Trp)
 
|9
 
|9 (Val)
 
|1 (Trp)
 
|3
 
|3 (Val)
 
| -4 (Gly)
 
|-
 
|rs121907968
 
|Trp -> Arg
 
|2
 
|2 (Arg)
 
|0 (all, except Arg, Phe, Ser, Tyr)
 
|2
 
|2 (Arg)
 
|0 (all, except Arg, His, Leu, Phe, Ser, Tyr)
 
| -3
 
|2 (Tyr)
 
| -4 (Asn, Asp, Pro)
 
|-
 
|}
 
 
[[http://i12r-studfilesrv.informatik.tu-muenchen.de/wiki/index.php/Sequence-based_mutation_analysis_HEXA#Summary_page Back to Sequence-based mutation analysis]]
 

Latest revision as of 16:34, 23 June 2011