Sequence-based mutation analysis BCKDHA

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Revision as of 19:41, 21 June 2011 by Demel (talk | contribs) (Subset of mutations)

Subset of mutations

Reference amino acid Mutated amino acid BLOSUM62 PAM1 PAM250 Secondary Structure
Position Residue Properties Structure Residue Properties Structure
29 G tiny, small E charged, polar C
125 Q acidic, polar E charged, polar C
166 Y hydrophobic, aromatic, polar N acidic, polar, small C
249 G tiny, small S polar, small, tiny, hydroxylic C
264 C sulphur containing, hydrophobic, tiny, small, polar W hydrophobic, aromatic, polar C
265 R charged, positive (basic), polar W C
326 I T C
361 I V C
409 F C C
438 Y N C

PSSM

PsiBlast was run using the following command: blastpgp -i sequence.fasta -j 5 -d /data/blast/nr/nr -C profile.ckp

SNAP

SIFT

Polyphen2

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