Sequence-based mutation analysis BCKDHA
From Bioinformatikpedia
Contents
Subset of mutations
Reference amino acid | Mutated amino acid | BLOSUM62 | PAM1 | PAM250 | Secondary Structure | |||||
---|---|---|---|---|---|---|---|---|---|---|
Position | Residue | Properties | Structure | Residue | Properties | Structure | ||||
29 | G | tiny, small | E | charged, polar | C | |||||
125 | Q | acidic, polar | E | charged, polar | C | |||||
166 | Y | hydrophobic, aromatic, polar | N | acidic, polar, small | H | |||||
249 | G | tiny, small | S | polar, small, tiny, hydroxylic | H | |||||
264 | C | sulphur containing, hydrophobic, tiny, small, polar | W | hydrophobic, aromatic, polar | E | |||||
265 | R | charged, positive (basic), polar | W | E | ||||||
326 | I | T | E | |||||||
361 | I | V | H | |||||||
409 | F | C | C | |||||||
438 | Y | N | C |
Annotation: H = helix, E = beta-sheet, C = coil,
PSSM
PsiBlast was run using the following command: blastpgp -i sequence.fasta -j 5 -d /data/blast/nr/nr -C profile.ckp
SNAP
SIFT
Polyphen2
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