Difference between revisions of "Sequence-based mutation analysis BCKDHA"

From Bioinformatikpedia
(Subset of mutations)
(Subset of mutations)
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|125||Q||acidic, polar||||E||charged, polar|| || || ||||C
 
|125||Q||acidic, polar||||E||charged, polar|| || || ||||C
 
|-
 
|-
|166||Y||hydrophobic, aromatic, polar||||N||acidic, polar, small|| || || ||||C
+
|166||Y||hydrophobic, aromatic, polar||||N||acidic, polar, small|| || || ||||H
 
|-
 
|-
|249||G||tiny, small||||S||polar, small, tiny, hydroxylic|| || || ||||C
+
|249||G||tiny, small||||S||polar, small, tiny, hydroxylic|| || || ||||H
 
|-
 
|-
|264||C||sulphur containing, hydrophobic, tiny, small, polar||||W||hydrophobic, aromatic, polar|| || || ||||C
+
|264||C||sulphur containing, hydrophobic, tiny, small, polar||||W||hydrophobic, aromatic, polar|| || || ||||E
 
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|-
|265||R||charged, positive (basic), polar||||W|||| || || ||||C
+
|265||R||charged, positive (basic), polar||||W|||| || || ||||E
 
|-
 
|-
|326||I||||||T|||| || || ||||C
+
|326||I||||||T|||| || || ||||E
 
|-
 
|-
|361||I||||||V|||| || || ||||C
+
|361||I||||||V|||| || || ||||H
 
|-
 
|-
 
|409||F||||||C|||| || || ||||C
 
|409||F||||||C|||| || || ||||C
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|438||Y||||||N|||| || || ||||C
 
|438||Y||||||N|||| || || ||||C
 
|}
 
|}
  +
  +
Annotation:
  +
  +
H = helix
  +
  +
E = beta-sheet
  +
  +
C = coil
   
 
== PSSM ==
 
== PSSM ==

Revision as of 19:42, 21 June 2011

Subset of mutations

Reference amino acid Mutated amino acid BLOSUM62 PAM1 PAM250 Secondary Structure
Position Residue Properties Structure Residue Properties Structure
29 G tiny, small E charged, polar C
125 Q acidic, polar E charged, polar C
166 Y hydrophobic, aromatic, polar N acidic, polar, small H
249 G tiny, small S polar, small, tiny, hydroxylic H
264 C sulphur containing, hydrophobic, tiny, small, polar W hydrophobic, aromatic, polar E
265 R charged, positive (basic), polar W E
326 I T E
361 I V H
409 F C C
438 Y N C

Annotation:

H = helix

E = beta-sheet

C = coil

PSSM

PsiBlast was run using the following command: blastpgp -i sequence.fasta -j 5 -d /data/blast/nr/nr -C profile.ckp

SNAP

SIFT

Polyphen2

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