Difference between revisions of "Sequence-based mutation analysis BCKDHA"

From Bioinformatikpedia
(Subset of mutations)
(Subset of mutations)
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!Structure
 
!Structure
 
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|29||G||tiny, small||||E||charged, polar|| || || ||C
+
|29||G||tiny, small||||E||charged, polar|| || || ||||C
 
|-
 
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|125||Q||acidic, polar||||E||charged, polar|| || || ||C
+
|125||Q||acidic, polar||||E||charged, polar|| || || ||||C
 
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|166||Y||hydrophobic, aromatic, polar||||N||acidic, polar, small|| || || ||C
+
|166||Y||hydrophobic, aromatic, polar||||N||acidic, polar, small|| || || ||||C
 
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|249||G||tiny, small||||S||polar, small, tiny, hydroxylic|| || || ||C
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|249||G||tiny, small||||S||polar, small, tiny, hydroxylic|| || || ||||C
 
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|264||C||sulphur containing, hydrophobic, tiny, small, polar||||W||hydrophobic, aromatic, polar|| || || ||C
+
|264||C||sulphur containing, hydrophobic, tiny, small, polar||||W||hydrophobic, aromatic, polar|| || || ||||C
 
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|265||R||charged, positive (basic), polar||||W|||| || || ||C
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|265||R||charged, positive (basic), polar||||W|||| || || ||||C
 
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|326||I||||||T|||| || || ||C
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|326||I||||||T|||| || || ||||C
 
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|361||I||||||V|||| || || ||C
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|361||I||||||V|||| || || ||||C
 
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|409||F||||||C|||| || || ||C
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|409||F||||||C|||| || || ||||C
 
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|438||Y||||||N|||| || || ||C
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|438||Y||||||N|||| || || ||||C
 
|}
 
|}
   

Revision as of 19:41, 21 June 2011

Subset of mutations

Reference amino acid Mutated amino acid BLOSUM62 PAM1 PAM250 Secondary Structure
Position Residue Properties Structure Residue Properties Structure
29 G tiny, small E charged, polar C
125 Q acidic, polar E charged, polar C
166 Y hydrophobic, aromatic, polar N acidic, polar, small C
249 G tiny, small S polar, small, tiny, hydroxylic C
264 C sulphur containing, hydrophobic, tiny, small, polar W hydrophobic, aromatic, polar C
265 R charged, positive (basic), polar W C
326 I T C
361 I V C
409 F C C
438 Y N C

PSSM

PsiBlast was run using the following command: blastpgp -i sequence.fasta -j 5 -d /data/blast/nr/nr -C profile.ckp

SNAP

SIFT

Polyphen2

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