Difference between revisions of "Sequence-based mutation analysis BCKDHA"

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(Subset of mutations)
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==Polyphen2==
 
==Polyphen2==
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Revision as of 19:38, 21 June 2011

Subset of mutations

Reference amino acid Mutated amino acid BLOSUM62 PAM1 PAM250
Position Residue Properties Structure Residue Properties Structure
29 G tiny, small E charged, polar
125 Q acidic, polar E charged, polar
166 Y hydrophobic, aromatic, polar N acidic, polar, small
249 G tiny, small polar, small, tiny, hydroxylic
264 C sulphur containing, hydrophobic, tiny, small, polar W hydrophobic, aromatic, polar
265 R charged, positive (basic), polar W
326 I T
361 I V
409 F C
438 Y N

PSSM

PsiBlast was run using the following command: blastpgp -i sequence.fasta -j 5 -d /data/blast/nr/nr -C profile.ckp

SNAP

SIFT

Polyphen2

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