Difference between revisions of "Sequence-based mutation analysis BCKDHA"

From Bioinformatikpedia
(Subset of mutations)
(Subset of mutations)
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!Structure
 
!Structure
 
|-
 
|-
|29||G||||||E||||
+
|29||G||tiny, small||||E||charged, polar||
 
|-
 
|-
|125||Q||||||E||||
+
|125||Q||acidic, polar||||E||charged, polar||
 
|-
 
|-
|166||Y||||||N||||
+
|166||Y||hydrophobic, aromatic, polar||||N||acidic, polar, small||
 
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|-
|249||G||||||S||||
+
|249||G||tiny, small||||S|polar, small, tiny, hydroxylic|||
 
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|-
  +
|264||C||sulphur containing, hydrophobic, tiny, small, polar||||W||hydrophobic, aromatic, polar||
|264||C||||||W||||
 
 
|-
 
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|265||R||||||W||||
+
|265||R||charged, positive (basic), polar||||W||||
 
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|326||I||||||T||||
 
|326||I||||||T||||
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|438||Y||||||N||||
 
|438||Y||||||N||||
 
|}
 
|}
 
   
 
== PSSM ==
 
== PSSM ==

Revision as of 17:12, 21 June 2011

Subset of mutations

Reference amino acid Mutated amino acid BLOSUM62 PAM1 PAM250
Position Residue Properties Structure Residue Properties Structure
29 G tiny, small E charged, polar
125 Q acidic, polar E charged, polar
166 Y hydrophobic, aromatic, polar N acidic, polar, small
249 G tiny, small polar, small, tiny, hydroxylic
264 C sulphur containing, hydrophobic, tiny, small, polar W hydrophobic, aromatic, polar
265 R charged, positive (basic), polar W
326 I T
361 I V
409 F C
438 Y N

PSSM

PsiBlast was run using the following command: blastpgp -i sequence.fasta -j 5 -d /data/blast/nr/nr -C profile.ckp

SNAP

SIFT

Polyphen2