Summary
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Multiple Sequence Alignment
Lab journal
The multiple alignment of Ras (PF00071) was downloaded from Pfam.
For our protein two domains are included (ACT and Biopterin domain).
Calculate and analyze correlated mutations
Lab journal
<figtable id="cn">
Ten results with highest CN for all and for extracted pairs
|
All pairs
|
pos1
|
aa1
|
pos2
|
aa2
|
MI
|
CN
|
6 |
L |
7 |
V |
0.502378 |
6.00544
|
162 |
E |
163 |
I |
0.469737 |
5.86548
|
83 |
A |
85 |
N |
0.347723 |
5.55586
|
15 |
G |
16 |
K |
0.435365 |
4.85938
|
159 |
L |
160 |
V |
0.47458 |
4.82084
|
9 |
V |
10 |
G |
0.456786 |
4.80473
|
161 |
R |
162 |
E |
0.460369 |
4.63455
|
124 |
T |
125 |
V |
0.338991 |
4.57508
|
10 |
G |
11 |
A |
0.457641 |
4.51696
|
16 |
K |
17 |
S |
0.453521 |
4.43534
|
|
Extracted pairs
|
pos1
|
aa1
|
pos2
|
aa2
|
MI
|
CN
|
11 |
A |
92 |
D |
0.324108 |
3.40452
|
81 |
V |
116 |
N |
0.24113 |
2.99935
|
87 |
T |
129 |
Q |
0.219978 |
2.68523
|
82 |
F |
141 |
Y |
0.246217 |
2.52757
|
84 |
I |
115 |
G |
0.156655 |
2.52503
|
19 |
L |
81 |
V |
0.14477 |
2.50461
|
82 |
F |
115 |
G |
0.136704 |
2.41712
|
10 |
G |
16 |
K |
0.39202 |
2.26146
|
130 |
A |
141 |
Y |
0.394896 |
2.24932
|
123 |
R |
143 |
E |
0.268723 |
2.21313
|
|
The ten results of freecontact with highest CN-value first for all pairs and second only for pairs with a distance of at least five residues. Both tables show the position of the first residue in column one with its corresponding amino acid (column 2) and of the second residue in column three with its amino acid in column four. The next one represents the mutual information score (MI) and the last one the corrected norm contact score(CN).
</figtable>
Calculate structural model
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References
<references/>