Difference between revisions of "Protein structure prediction from evolutionary sequence variation (Phenylketonuria)"
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====RASH_HUMAN==== |
====RASH_HUMAN==== |
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[[Lab Journal - Task 6 (PAH) #Calculate and analyze correlated mutations |Lab journal]] <br> |
[[Lab Journal - Task 6 (PAH) #Calculate and analyze correlated mutations |Lab journal]] <br> |
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− | <code>Freecontact</code> is a program that takes a multiple alignment and can calculate the mutual information score and the corrected norm contact score. MI:... CN:... |
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<figtable id="cn-ras"> |
<figtable id="cn-ras"> |
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Revision as of 12:26, 15 June 2013
Contents
Summary
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Multiple Sequence Alignment
Lab journal
The multiple alignment of Ras (PF00071) was downloaded from Pfam.
For our protein two domains are included (ACT and Biopterin domain).
Results
RASH_HUMAN
Lab journal
<figtable id="cn-ras">
Ten results with highest CN for all and for extracted pairs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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The ten results of freecontact
calculated for RASH with highest CN-value first for all pairs and second only for pairs with a distance of at least five residues. Both tables show the position of the first residue in column one with its corresponding amino acid (column 2) and of the second residue in column three with its amino acid in column four. The next one represents the mutual information score (MI) and the last one the corrected norm contact score(CN).
</figtable>
Distribution of CN-Scores:
<figure id="cn_distr_ras">
</figure>
PH4H_HUMAN
<figtable id="cn-pah">
Ten results with highest CN for all and for extracted pairs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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The ten results of freecontact
calculated for the biopterin domain of PAH with highest CN-value first for all pairs and second only for pairs with a distance of at least five residues. Both tables show the position of the first residue in column one with its corresponding amino acid (column 2) and of the second residue in column three with its amino acid in column four. The next one represents the mutual information score (MI) and the last one the corrected norm contact score(CN).
</figtable>
Distribution of CN-Scores: <figure id="cn_distr_ras">
</figure>
Discussion
Calculate structural model
Lab journal
...
References
<references/>