Difference between revisions of "Gaucher Disease: Task 05 - Homology Modelling"

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(Structures from task 04)
(Structures from task 04)
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==Structures from task 04==
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==Calculation of models==
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===Structures from task 04===
 
We assembled the following structures in [[Gaucher_Disease:_Task_04_-_Structural_Alignment]], now we divide them into two groups at
 
We assembled the following structures in [[Gaucher_Disease:_Task_04_-_Structural_Alignment]], now we divide them into two groups at
 
* > 60% sequence identity
 
* > 60% sequence identity
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==Evaluation of models==

Revision as of 00:04, 10 June 2013

Calculation of models

Structures from task 04

We assembled the following structures in Gaucher_Disease:_Task_04_-_Structural_Alignment, now we divide them into two groups at

  • > 60% sequence identity
  • < 30% sequence identity (ideally go towards 20%)

For not glucocerebrosidases, we calculated PID as follows:

  • first aligned the two fasta sequences from PDB with ClustalW
  • then calculated the PID using SIAS with default options
Homologous structures to 1ogs_A
> 60% PID < 30% PID
2xwd_A (82.77%) 2f7k_A (9.65%)
2nsx_A 2gep_A (9.66%)
2nt1_A 2isb_A (7.17%)
2djf_B (5.68%)
2qgu (7.17%)


Evaluation of models