Fabry Disease Mutation Analysis Sequence PSSM
From Bioinformatikpedia
The point specific position matrix of the PSI-BLAST run with the α-galactosidase sequence. Only the positions are listed that a examined in respect to a certain mutation.
| Number | Amino acid | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 42 | M | -3 | -2 | -5 | -6 | -4 | -3 | -5 | -6 | -5 | 1 | 1 | -4 | 9 | -1 | -5 | -4 | -3 | -5 | -4 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 12 | 1 | 58 | 2 | 0 | 0 | 1 | 0 | 0 | 15 | |
| 65 | S | -2 | -1 | 5 | -1 | -3 | -2 | -2 | -2 | -1 | -3 | -3 | -1 | -3 | 0 | -2 | 3 | 3 | 0 | -1 | -3 | 2 | 2 | 28 | 3 | 0 | 1 | 2 | 2 | 1 | 1 | 2 | 3 | 0 | 4 | 2 | 20 | 20 | 1 | 2 | 1 | |
| 117 | I | -4 | -5 | -5 | -6 | -4 | -4 | -5 | -5 | -5 | 4 | 4 | -5 | 5 | 3 | -2 | -3 | -4 | 1 | -1 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 25 | 35 | 0 | 17 | 11 | 2 | 2 | 0 | 2 | 2 | 1 | |
| 143 | A | 1 | 1 | 0 | 2 | 1 | 0 | -1 | 0 | 2 | -1 | -2 | -1 | 2 | 0 | 1 | -1 | -1 | -5 | 0 | -1 | 14 | 7 | 4 | 11 | 3 | 5 | 5 | 6 | 5 | 3 | 4 | 3 | 5 | 5 | 6 | 4 | 4 | 0 | 3 | 3 | |
| 186 | H | 2 | 1 | 1 | -1 | -5 | 1 | 1 | -2 | 0 | -1 | -1 | 0 | 1 | -1 | 1 | -2 | -1 | -5 | 1 | -1 | 17 | 9 | 6 | 3 | 0 | 7 | 9 | 3 | 3 | 3 | 5 | 5 | 3 | 2 | 8 | 3 | 4 | 0 | 6 | 5 | |
| 205 | P | -1 | -2 | 1 | 1 | -5 | -1 | 2 | 3 | 1 | -5 | -2 | -2 | -4 | -1 | 2 | 0 | -2 | -5 | -1 | -4 | 6 | 2 | 7 | 7 | 0 | 2 | 14 | 24 | 4 | 0 | 5 | 2 | 0 | 3 | 12 | 7 | 2 | 0 | 2 | 1 | |
| 244 | D | -2 | -2 | 3 | 4 | 0 | -2 | 0 | 0 | 1 | 0 | -1 | -1 | 1 | -3 | 0 | -1 | -1 | -5 | 1 | -2 | 3 | 2 | 13 | 23 | 2 | 2 | 5 | 7 | 3 | 6 | 5 | 4 | 3 | 1 | 6 | 4 | 3 | 0 | 6 | 3 | |
| 283 | Q | -2 | 2 | -2 | -3 | -5 | 3 | -2 | -4 | 8 | -2 | -1 | -2 | 1 | -3 | -5 | -2 | -2 | 0 | -1 | -1 | 4 | 11 | 1 | 1 | 0 | 15 | 2 | 1 | 37 | 2 | 8 | 2 | 4 | 1 | 0 | 2 | 3 | 1 | 2 | 4 | |
| 321 | Q | -2 | 1 | -2 | -2 | -5 | 7 | 1 | -4 | -2 | -4 | -3 | 1 | -2 | -5 | -3 | -2 | -3 | 1 | -3 | -4 | 2 | 6 | 1 | 1 | 0 | 62 | 7 | 1 | 1 | 1 | 2 | 8 | 1 | 0 | 1 | 2 | 1 | 2 | 1 | 1 | |
| 363 | R | 0 | 2 | -2 | -3 | -1 | 3 | -1 | -4 | -1 | 1 | 0 | -1 | 3 | 0 | -3 | 0 | -1 | -4 | 2 | 1 | 7 | 13 | 1 | 1 | 1 | 12 | 4 | 1 | 1 | 8 | 7 | 4 | 6 | 3 | 1 | 6 | 4 | 0 | 7 | 11 |
