BCKDHA
From Bioinformatikpedia
BCKDHA is the α subunit of branched-chain α-keto acid dehydrogenase complex. The gene which encodes BCKDHA locates on chromosome 19.
Contents
Reference sequence
Genomic sequence
>gi|260593636|ref|NG_013004.1| Homo sapiens branched chain keto acid dehydrogenase E1, alpha polypeptide (BCKDHA), RefSeqGene on chromosome 19 GGCAGCTGGTAGGGAGGAGCTGGGGGGGTGATTTTGACAAACTGGGCACCACTCAGAGGTTCAGCAGGGC CCAATTACCAGGCAGCCCAATCTTCGGCCTCAGGATCACTTCGAGTGTGGCCTTGTTGAAAATCTCTTTG CTGACCTTCACCTCGGCCGGCCCGTACACACCCGCCAGGACAGAGGTGTCACCTGAGGAGACAGCAGGGA GGGCCTCACTCACAGCTTCCCTGCTCCTGGGGCCCCATTTGTGGCACTGAGCCTGACGGCCAGGGCTCCC CACGTCACCCCCGCCATTTGTTGGTACTGATTCTTTGAGCACTCACTTCATTTCTCTCATTTGTAAAATG GGGAAAATAGCAGTCCCTCCCCGCTAGCGTCTTGTGAGGATCAAAGGACACAATTCACAGAAAACACTTA GAACACTGCGGGGCTCACGCTGAATGTGCAACAGACTTTAGCTGTATTAGTAACATTCGTCCATTCAGGC ATTCAGGCAGGGTCTCACTCTCATTGCCCAGGCTGGAGTGCAGTGGTGCCATCACGGCTCATTGCAGCCT TGACCTTCTGGGCTCAAGTGATCCTCCCGCCTCAGCCTCCCAAGTAGCTGGAACTACAGGCATGTGCCAC CATGCCTGACTAATTTTTATATTTTTAGTAGAGAGGGGATTTTGCCATGTTGCTCAGGCGGGTTTCGAAC TCCTGGGCAACTGTAATCCCAAGGTGCTAGGATTACAGGCGTGAGCTACCACGCCTGGCCCTGATATTAG TAATTTTTTTTTTTTTAATGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTAATCTC GGCTCACCGCAACCTCTGCCTCCCGGGTTCAAGCAGTTCTCCTGCCTCAGCCTACTGAGTAGCTGGGATT ACAGGCGCGCGCCACCACACCTGGCTAATTTTTTTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGTC AGGCTGGTCTCGAACTTCCTGACCTCATGATCTGCCCGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGC CACTGTGCCCGGCTGGTATTAGTAACTTTTAACAGGAAGTTCTTCCTGAAAGCTAACCATCCTCCCTCTT ACTGCAGCTGCTCTCAACTTCTCTTTCCAAAGCTTCCCCAGCCCAGCTCTTCCCTTAGGCACTGGCCCCC AAATTTTGCATCAGTCTGGACACCTGAGAAAGGGATAATATCTGGAATGAATCCTGATTCCTTATTTCCC CAGAAGCTATGAACGGGGTACAGGAGGTAAAACCTAAGAAATAAACAGCCTGGCTTCTAGTACTGTCTGC TGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCATCCTAG TCAACATGGTGAAACCCTATCTCTACTAAAGATACAAAAATTAGCTGGGCATAGTGGTGGGTGCCTGTAA TCTCAGCTACTTGGGAGGCCGACGCAGGAGAATTGCTGGAACCGGGGAGGCGGAGGTTGCAGTGAGCCGA GATCACACCATTGCACTCCAGCCTGGACAATAACAGCAAGGCTTAGTCTCAATAAAAAAAAAAAAATACA TTTTAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCACTATGGAGGCCCAGGTGGGAGGACTGCTT GAGGCCAGGAGTTTGAGACCAGCCTGAGCAGCATAGGAAGACTCCTGTCTCTATTTTCTTTTTTGGGACA GAGTTTCCCTCTGTCACCCAGGAGGCTGGAGTGCAGTGGCGCAATCTCAGTTCACTGCAACCTCCGCCTC CCAGGCTCAAGTGATTCTTGTACCTCAACCTCCAGAGTAGCTGAGATTACAGGTGCGTGCTACCACATCC GACTAATTTTTGTATTTTTAGTAGAGATGGGTTTTCACCATGTTGGCCAATCTGGTCTCAGAACTCCTGA CCTCAACCAAGCGAGGTGGCTCACGCCTGTAATCCCAGCACTGTGGGAGGCTGAGGCAGGTGGATCACAG GGTCAGGAGTTCAAGATCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAACCACAAAAATTAG CCGGGCGCGGTGGCACGCACCTGTGGTCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATTGCTTGAACCC GGGAGGTGGAGGGTGCAGTGAGCCACGATCACTTCACTGCACTCCAGCCTGGGCGACAGGGCGAGACTCC ATCTCAAAAAAAAAAAAAGAAAAAAAAAAAAAGAACTCCTGACCTCAGAGGCCTCCCAAAGTGCTGGGAT TACCGCTGTGAGCAACTGCACCCGGCCTCTTCTTAATTCTTACGTTCGAAGAAACTTTAGGTATCTCAAT TCAGCATAAGCGCTAAGCCTGAGGGAGGGCCTGGGAAGGTCCTTGGTTAAGGCCGTATTTCCTGGGAAGC CCAATTTGCCCTTACACGGAAGGTATGCTTAGTTCCAGGAGAAACTGCCCTGAGGACTGGAGAAGTTACC AAAACAGAACTTGCCTCTGGCTCCAGATGAACTGCCTGTGTTTTGCCCGAGCACAAGAGTCTCTCCCCTC TCACCTTCTTGAAGACGTGGCTCCAGCAATTCTCTCCCCTGTTGACCCCACAACAATCTACAACTCCTGC CCCACTTATCTGATCCTCTTACAGCAGAACTCCTGAACAGCTGCCTCTTCTTCCTTTTCTGTGACCCCAC CACTCCATTGCGGCAGCTCAACATCGTCACCACTGACCTCCAAATGATCAACCCTCCCATGACCCGGCTG TCAGTAAGGCTGAAACAGCTGGTCAGCCCTCACATCTCAGACATGCTCTTTTCTTGGCCCCAGGTCACCA CCATCTCCTGGTTTCCCCCTAACTCTCTGGGCGTTCCTTCTGAGTCTCCTTTGCTAGCTTGTCACATGTC TCTGACTGCTCAAGTTGGAAGGCCTAGGGCTTGGTCCTGGGACCTCTTCTCTTTTCCATCTACACTCACT TCGTTCAGGCAATAGCCTGAAATACCATCTATATAGCCAGAGAGTTCCAAATTGCCTATGTCCAGCTTGG GTCTCTCTTCTGATTTCCAGACTTGTACAGATCTGGGCAGAAACCTTAGTTATGCCTGAATCTTTTTCCT CGCACTCAAACCAAACTATACGTAAGTTTTGTCCGTATTACTTTCAAACTACATCCAGAATCTCATCACC TCCACTACTCCTGCTCTGGCTGGAGCCACCATCACCTCCCTGTTTTCCCCCATACTCCCCACAATCAACA CAGCAGCCAAATTTTGTTAAAATGTATTGGGGCTGGGCGTGGTGGCTCATACCTGTATGAGCACTTTGGG AGGAGGATTGCTTGAGCCCAGGAGTTCAAGACCAACCTGGGTGACATCGTGAGACGCTGTCTCAATTTTT TTTTTTTTTGAGACAGAGTCTTGCTTTGTCGCTCACGCTGGAGTACAATGGCACGATCTCGGCCCACTGC AACTTCTGCCTCCCAGGTTCAAGTGATTGTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCCC GCCACCATGCCTGGCTAGTTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCCAGGCTGGTCT CGAACTCCTGACCTCAGGTGAGCCACAGGTCTTGGCCTCCCAAAGTGTGGGGATTACAGGCGTGAGCCAC CGCCCCCGGCCTCCCGTCTCAAACGTTAAAGAGAAATATTCTTGGAGTTAATCTACTTCTGAGAGTTATT TAGCTAGGAAAAGGGGATATTTGCTCTATAGGTAAGACTTGCCCTAATCTTTTTTTTTTTTTTTTTTTTG ACTTGCCCTAATCTTAGGGATATTTACTTGTGTGGAGAGATGCAGTGAGGTAGCGGTGGGGATGTATTTC TCAACCCAGCGCAATGACATTATCTTCAATTTGAGGAGTATTTACGTGGGTGAAAGATCCGCCACAGTCC ACAGTATGCAAATAGACAGGTTTGCTTCAGTCCGGGATGCAAGGACCTAGAGGGTGTGTGTGTGGGGGGT GGGGGTGGGAGGGTGGAGGAGGAATCGAGTTAAGGGGGATATTTACCCTGGCGAGGTGATTTTCCCTATT CTGAAATATCAATTCTTGGGCGGACAGTCTGCCCCTCCTCTCATTCTCAGAGATAGTTACAAAGATGGAA CTATCTTCTCCTTTCTAGTCGTGAGGGAGAGATGTGTGTATCCCTGCGTATTTAGTAGTATTCAATCGGA CAAGAAATCATGCATCAACGCAGGAGTGACATTTACCAGCTGGTATCGTGAGGAGGTGGGCACTCGGTTG CACAGTACACGGTAGTCCCTCTCCAAAAGAAAGACCTGGGTGAAGTTCTTACCTTGCAGGAAGGAAGCAG AGCCATCTGGCCGCGACAGCAGGTTCTGTTCGCAGGCAAAGTGCCGGAGGCTGCAGCCAGGACCCCGAGG GCTGGACCCTGTTCCATTTTCAGCACGGATTTTGGCGTCAGTATGCGTCTCCTCCTCCATCGCGCCGAGC CCACGTGCGGCTGCAGTTGTCACTTCCGCCTGGCAGCGCGCGCCGCAAACAGGCTGCGTAACCAGTGCGC ACGCGCCGGGCTGGGCCATCCTCCTGGGCGTCCGCACGTGGCTTAGCGTTTACCAACAATCTGGCTCCGC CCAGTCCCACCTCCTAACTCTGGCAACGCCATTGGACATTTGGGAACAGAAGGCAGGCCTTGGCATTGAT CCGCTTTACTCTGGGCCCCCGGGCCCTAAATCCCTGAGGCCCTGGTCAGGTTGCCCTCTTCTTTGCCTGT TACAGGAGTAACTACAATGAGGCGATTGGAGAAAATTTTGGGTAGATAGATTTTTTTTTCTCCAAATCTC TGTGCATTCTATCTACCACAGAACGGGAAGAAGATGGTTTTCTTGTCAGATGGTGCTGGAGTTTGCGTCA GGCACATAAAGAGGCAGCCCCGAATCTAGCCTACGTGAGTGCCGGACCGCTGAGTGGTTGTTAGCCAAGA TGGCGGTAGCGATCGCTGCAGCGAGGGTCTGGCGGCTAAACCGTGGTTTGAGCCAGGCTGCCCTCCTGCT GCTGCGGCAGCCTGGGGCTCGGGGACTGGCTAGATCTGTGAGTACCTGGGCCCCAGGCGGTTTTCCCAAA GGGGATTAGGGATGTAAAGGCTATCTTCAGAGTGTGGGGTCCCTGAAGGATATGAAGGAAGGGCTGTCAC AAAAGGGAAAAAGAGTGGGAGACTCCTTGGAGAAGACACCGAAGGGAAGATCTGCCACTTCCTTAGGAGA CGAAAAGAACTTCCACTTCTTTAGGAGAGGAAAAAACCCGTTTGCAACTTCTTTGTGGGCCCTGAGGGAG ACGACTTGAAGAGAGAGATGGGGGTTCCTTATTAGCTGCCACTGGTATTCAGGGGAGGCTCCTTGGAGGA ACAGGGGAAGACCGCAAGACCTTCTCCCTCAGGGTTTGGAGAATGAAACTGACTTTGTAAGGGAGGGACT TTCTTCTGGGCAAAGATCCCTCTTCAAGAAGAAGAAAGAAGAGAACAGGTCCCTGTCACAGGCTGCATAG GGCCTTGTATTTCTTTGCTCCTTTGCCACAATTCTGATTTTAAAATGAATTGTGTAAAAAATTTGTTTGA TTCCTGTGTCTCTTGATCGAATATCAAGACAGAGAATTCGTGTGTTCTGGACACTGTACAGAGGAGACGA TTAATATTTGTTGAATTAATGAGGGGAAAAAAGGAGGGAGAGAGGTACAGACAGGGCACTTTGCCCACAT TTCTTAGAAACACTTGAGAAGGCTTTGTTTCTTGTCAAAAGGGTCACAATCCCTTCAGGTGGATGCTGCT AAGGGCAAGATTACACTGCAAAAAACCTAGGTGGAAGCCTATCTTTAGACGGGGAGAGGCAATGGGTTGC AGAAGAGCTTTGAACTACAGTTGACAGATAGGAGAGTAGTGGTTACATGGGTGGATGCATGTCCTTGCTC TGCCGCTTTCCACTTGTGTAGCCTTGGCCAACGGACTGCACTTCTCTGGATCTATGGAGCTAATTTTCCT CTCTAAAATATTAACAGTGGCCACCTCATAGGGCTGTGAAAAATCAATATGTAAAATGCTAAGGACTGGA CCTGGCACATCCTAAGGGCAATAGGAATGTTGATAGTGAGGGTGGAGGGAAGGGACAGAAACTAACCTTG GAGATGGGGAGAAGAAAGGGGTGACCTTGGGAAGGCCTGGATTGGTGAGGCCCTGGGGAAAAAAATCTGA AAAGATATTGTGAGGTTGAGTCTGATCCTCTGATCCCCAATCCATAAGGAGGGGAAGATGGAATCTGTAG AAAGAAGCTCTGGGTAGGGGAACAAACGGGAGGAGGGTGAAGAAGATGGGCCAGGAGTAGGACGTAGTAG GTATCTAGGAACGGAGTCACTTGAAACAGGTAAATACAGAAGGGCTGCAGGAGCAAGGTGTGGGTAGGGC AGTCTCTTGCCTTTGGGCTGGAGACCTTTTCACTTTTTTTTTTTTTTTTTTTTTTGAGCAGTTCATATCC TCCACAGCTGATCTCAGTCCCAGGGGCCCATTGGCTGGGCAAGTGGGGCAGGAGGTGGGCAGGACTGGGG CAGGCTAGGGAAAGGTCATTTATGGCTGATTAAATCTTTCTCTCCTGTCTCAATCTCTTGATTACCTTTC CTCTTGCTTCCCCTACTTCATTTTTGGTGGGGAGTGGGGAGGGAAGAAGTCCCTACTTTTTATTTATATA TATTTAAATTTGTATTATCTTAAGAGTTATTGTTTTTTCCCCTTTATTTCTCCCACCTGTTCTTTCTCTC TTCTTCTTTCTTTCCTCTCCTTCTCCTCTCCTCTCCTCCCCTCTCCTTTTTCTTTTCTTTTCTTTTTCCC TTTCCTTTCCTTTCCTTTTCTCTTCTCTTTTCTCTCTCTCTTTCTTTCTGTACCTCTCTTTCCTTTTTCT TTTTTTTTCTTTTTTGAGACAGAGTTTCACTCTCTCGCCTAGGCTGGAGTGCAGCAGCATGATCTTGACT TACTGCAATCTCTGCCTGCCGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAG GCATGCACTATCACGCCTGGCTAATTTTTGTATTTTTGGTAGGGACGAGGTTTCACCATGTTGTCCAGGC TGGTCTCGAACTTCTGGCCTCAAGTTCCGCCTGTCTTGGCCTCCAAAAGCATGAGCCACTGCGCCTAGCC TTTTCTTTTTTTGAGACAAGGTCTCACTCTGTCACCCAGGCTGGAGTGAGTGCAGTGGTGTGATCATGGC TCACTGCAGCCTCAACCTCCTGGGCTCAAGCAATCCCCCCACCTCCACCTCCTAAGTAGCTGGGACCACA GGCACGTGCTACTACGCCTGGCTAATTTTTAATTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTC ACCCAAGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAACCTCCACTTCCCAGGTTCAAGTGATTCT CCTGCCTCAGCCTCCCAAATAGCTGGGACTACTGGCGTGCGCCACCATACCCAGTTAATTTTTGTATTTT TAGTAGAGATGGGGTTTCACCATGTTGACCAGGCTGGTCTTGAACTCCTGATCTAAGGTGATCTGCCCGC CTCGGCCTCCCAAAGTGCTGGGATTACAGGCATAAGCCACTGTGCCTGGCTGCGCCTGGCTAATTTTTAA ATCTTTGTAGAGATGGGGTTTTGCCATGTTTTCCAGGCTGGTCTTGAACTCCTGGACTCAAGCGATCTTC CTGCCTCAGCCTCCCAAAGTGCAGGATGACAAGCGTGAGCCACCTTGCCTGGCCATATTATTAAATTATC ATGAGTTTAAGTTTAAGTAGCCACAAGTGGGCTGGGTGCGGTGGCTCATGCCTGTAATCCCAGCATTTTG AGAGGCCAAGGTGGGCGGGTTGCCTGAGGCCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCC ATCTCTACTAAAAATACAAAAAAATTAGCTGGGCGTAATGGCGTGTGCCTGTAGTCCCAGCTACTTGGGA GGCTGAGGCAGAAGAATCGCTTGAACCTGGGAGGCGGAGATTGCAGTGAGCCGAGATCGCACCACTATAC CCCAGCCTAGGTGACAGAGCAGCCCTCTGTCTCAAAATAAGATAGCCACAAGTGGTTGGTGGCTGCCACA TTAGATGGTGCAGGGTTTTTGTTTTGTTTTGTTTTTTGTTTTTTCGAGGTGGAGTTTTGCTCTCATTGCC TAGGCTGGAGTGCAATGGCATGATCTTGGCTCACCACAACCTCCTCTTCCTGGGTTCAAGCGATTCTCCT GCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCACCACCATGCCTGGCTAATTTTGTATTTTTAGT AGAGACAGGGTTTCTCCATGTTGATCAGGCTGGTCTTGAACTCCCGACCTCAGGCGACCCACCCACCTCG GCCTCCCAGAGTGCTGGGATTACAGGTGTGAGCCACCATGCCTGGCTAAGATGATGCAGTTTTATCCAGG TGGAGATGAAGAAATAGTCAGGGAAAGGTTGAGAGGCTGCATATTGTAGACAGATTGGATTACTGGGTTC ACTGGGGAAGATTGGATTAGAAGGAGGAGTGGGGCTGCTTTACTTGTCCCCGACTTCTTGCCCCTGCTCT GCCCACTCCTTCATTGAATACCCTGCTGCCCTGCAGATGTGTTTGCCTGATTTTCACCTCCCTTCCTGTC TCTGTTATCATAGCAGACGTTTTAGTGCTCAGGGAAAGGAGGAGGAAGGAAACTCAGATTGTCAAGGAAT TGTGAGTCAGTTTCTCAGCCACTACCCCAGGCCTGGGCTTGGCTAAGTCATTTCACCTCTCTGACCCTAG CTAGTGGGGTGAATAGAGTCCCTACCCTGTTGGAAGTCAGGAAGCCCCTGGAGCTCGCTCTGTGCTAATT ATCGGTGACTATTTCTGTGACCCAGCTCTTCAGGGGCAGCCTGTCTGGGGGTTCCAGTGCCCTGTGCAGT ATCTCCAAGTGGTAGGTACTCAGTGTATGTATTAGTCCGTTTTCAGGCTGCTAATAAAAACACACCCAAG ACTGGGTAATTTATAAAGAAAAAGAGGCTTAATGGACTCACAGTTCCACATGGCTGGGGAAGCCTCACAA ACATGGCGGAAGGCAAATGAGGAGCAAAGTCACATCTTACATGGTGGCAGGCAGACAGAGTGCTTGCAGG GGAACTCCCCTTTATAAAACCATCAGATCTCGTGAGACTTATTCAGTATAATGAGAACAGCACGTGAAAG ATCCACCCCCATAATTCAATTACCTCCCACTGGCTCCTTCCCACAACATGTGGGAATTATGGGAGCTATA ATTCAAGATGAGATTTGAGTGGGGACAGAGACAAACCATGTCAGTGTGTATTGTGGGATGAATGGAGATG GTCATTACAGTCTTCTAAGTGTATGGGTCCATCTCTTACTTGCTAGTGTGTTAAGAAACCTGGCCTCCTT TTTCACATCTTGAGGCACTGAATGGTTTACAAATCCAACTCTAATTTTTTATTATATTTAATACACCAAT AGTGCAAGGCCTTTATTGGTAGTACTCTCCTATTACAGATGGAGAGACTGAGGCTCAGAGAGGTGAGGTC TGAACTTGGAGCTCTGGACTCCAAAACCCAGTTTCTTTTCATGGTACCAGGCTGCCAGGAGGAGAAAGGA TGGAGCTTAGATTCAAGTCTTGCAACATTCTTCTTAGTCCAGTATTGGCTTATTTTGTTTTATATTTTTT TGAGACGGAGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGGCGTGATTTCTGCTCACTGCAACCTCTG CCTCCTGGGTTAAGCGATTGTCCTGCCTCCCCCTCTCGAGTAGCTGGGACTACAGGTGTGTGCCACCGTG TCCGGCTAATTTTTATATTTTTAATAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAACTCCT GGCCTCAACTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGGTTACAGGCGTGAGCCACCATGTGTGG CCGGGCAGGTGATTTTTCTTGTCTTTCGCCTCTTTCCACTTCAGTCCCCCTGGCCATCTTTCCCTTCCTT GAATGTGCCTCCTCCCACCTGGTGGCCTTTGTAGGTATGAGGTCCTTCAGATGATGGCTGACATGACACT TCCTCAGAGAAGCGTTCCAGACCCCAAACACCAGGTCTCTGTCTGTGAAACAGGGACAGTGATACCTGCC TAATCTGCACGCCTTTCCCTTCTCACGAGATATTCTGGGAAGGGGGACTCAACTCTTTGCTCTGTTTGAG GGCAGAGTGCCTTTGAGCTCAGGAGAGAGTGGGTTTGGGTGGCCTTAGCTACCCTAGATACGGAGGACTT GGAGTTAACTGGCACCATCCACAAAGCCTTGCATGCACTGGACCTGAACAAGTTGCTTAGCCCTTGAGGC GGCGCCTCAGCTACCACCTGTCTTTGATGGAGTTATGATAACAGTGCCTGCCCCGTCTGGATGCCTTATG GGTTCAGTGAGCACATAGGTGTAAATAAAGTGCTTTGAGTGGCACCTCAGCATGTAGTTATTCTCTGATT GACCTATAGCAGCCATGCCAGTCTTCAGGGTCCCAGGGCGCCAGGCTTTCTTCTCTTGCCTTGGAGCCTT GGTTTTTCCCTAGGACTGAAGTGTTCTGACCCCTTGGCTGAACTCCCCCTTCTTTAGGAAGCTTTCCCTG GTGTGCCATCTGATGCTGGTGCTTCCTGGAGGGGTACTATCTGATCCTAGCTGGTGAGGCATTCCTGCCA GAGCTGCGGCAGGTGCTTTCCCCGCCTCTCCACCAGCCTGTGAGGTGGATGCCATCCCCACGAGGGCACG CAGGTTCACAGAGACTGGCTCCTGTCCAAGGCCGCGTGGCTGGAAAGAGACAGAACCAGATTCAAACACC AGCAGTTTAACCCTAGAGACCCTCATCCTACCTCCTATGTGGGTAACCACTATACATCCTGCCTCCTCTG AAATCTCCCGTTTTTTTTTATTTTAAAATTTTATGTGAGTATTTACTTATTTATTTGCTGCTGTTGTTAT TGTTTTGAGACAGAGTCTTGCTCTGTTTTCACCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCACTGC AACCTCTGCCTCCTCGGCTCAAGCGATTCTCGTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGACATGC ACCACCATGCCTGGCTAATTTTTGTGTCTTTAGTAGAGATGGGGTTTCGCCATATTGGCCAGGCTGGTCT TGAACTCCTGGCTTCGAGTGAACTGCCTGCCCTGGCCTCCCAAAGTATTGAGATTATAAGCATAAGCCAC TGTGCCCGGCCAAAATTTTATTTATTTATTTATTTTTTTGAGATGTAGTCTTGCTCTGTCACCCAGGCTG GAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCTGCCTCCCAGGTTGACGCCATTCTCCTGCCTCAG CCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGA TAGGGTTTCACCTTATTAGCCAGGATGGTCTCGATCTCCCGACCTCATGATCCGCCCGCCTCGGTCTCCC AAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGCCTAATTTTATTTATTAATTTATTTGAGATGG AGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCACTGCAACCTCCACCTCCCAG GTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTATAGGTGCGTGCCACCACGCCTGGCT AATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCGTGATCAGCCTGACAGGCTGGTCATGAACTCC TGACCTTAAGTGATTCACCTGCCTCAGCCTCCCAAATCTGCTGGGATTACAGGCATGAGCCACCGCACCC AGCCATATTATTTCTGTATTTTCATTTGGCTTACCTGTCAACTTGACACTTTTTTGTTTTTTTAGGCTAG TCAGGTGAAGCAATGTGAGTAAGATCACCTGTCTTGATTATAACTTGTGTGTTCAGTGTTTGTCATTCAT CCCTCCCTGTCTCTAGCCTTCAGTTCAGGGCATGATTTGGAGCAAATGTTCAGTATCTGTTTAACAAGAA CAATCATGAGAAATACTTACTCACTACTTGTGTTTATGAAACATTATGTGCCAGGCACTGGGCTGAGCAA TCCACACAGGTCAACTCGGTTAATCCTCATGACAACCCCTGAGATAAGTACTTATACCACCCTCGGTGTA CACAGGAGGAAACTGAGGCTCAGGGAGTTTTTCTTTAAAAATTTTTTCTTTTTTTTTTCCTTGAGACAGG TCTTACTTTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAGCCTCTTGGGCTCCAGC GATCCTCCCACCTCAGCCCCTCAAGTAGTTGGGGAGTACAGGTGTGCACCACCATGCCCAGCTAATTTTT TGTAGGGATGGGGTCTTGCCATGTTATCCAGGCTGGTCTTGAACTCCTGGGCTCAAGCGATCCTCCCTCC TTGGCCTCCCAAAGTGCTGGTATTACAAGTGTGAACCACCACACCTGGCCTTAAATTTTATTTATATATT TATTTTTGTAGAGACGAGGTCTCACTATGTTTCCCAGGCTGGCCTCGAACTCCTGGACTCAAGTGATCCT CTTGCCTCAGCCTCCAGAGTAGCTAGAATTACAGGCGTCTGCCACTGCACTTGGCTCAGGGAGTTTAAGT CACATAATCAGGCAGCGGTCTGCTCAGTTAGAGTCCATGCGCTTAGCCATGGTGCCTTCAAGTGACTCCA CCAGGGTCACCCCAGTACTTCCTGGGCAGACCAGACCATCCAGAGCGGGCAGGTTGTGCTTTCCTGCATG GTGGGAGAGGACGTGGCATGAAGCTTTGTGTAAATCTGTGCAGCCTCTGCCATTGTAAATCACTGGCCAC CGGGACAGACTCCCCCACCCCCTTCCAAAAACTAGAGGAACAGATGGGTGGAGTCGCATCCTTCCTCTGC AGGCATTTGGCCACCCACTCCCATTATGGAGCATTTCCTCAGGACCAGGCACAGCGTGGAGCCCTTTGCA TAGCTCACTGAATTGGGGCAGCAACCCTGGGGCTGGGGACTACCATTATCTCCACCAGCCCAGCAAAGAG GGGAGGAGGGTACAGCCGAGACCCAGCTGCAGTATGTGGAGCACACTGGGGTGCCGTGAAGATAGCTGTC CAGCCTCTAGAGGCTGACAGTCCTGCCCTGACACAGTGGTTTGTTCTCAGACTCTGGCCTCCCCTCTTAG TGCCCGTCTGAAGACTTCAGCCTTCGGTCCTCTTCCATCAGCATGCCGTCTCCCCTGTGCCTCAGTCTCC CTCTCTGGAGTATCTGCTGGGGCCACAGTTTGGTTTTATTGTTCTTTGAGACAGGGTATCACTTTGTTGC CCAGGCTGGAGTGCAATGGTGCAGTCATGGCTCACTGCAGCCTTGACCTCCTGGGCTCAAGCCATCCTCT CACCTCAGCCTCCCGCAACTCCAGTATCTGGACTACATGTAAATGCCACCATTCCCAGCTAATTTTTTTT TTTTTTTTTAGATAGAGTCTCACTCTTGTCACCCAGGCTGGAGTGCAATGGTGCCATCTTGGCTCACTGC AACATCCGCCTCCCAGGTTCAAGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCT ACCATCATGCACGGCTGTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTGGCCAGGCTGGTCT TGAACTCCTGACCTCAGGTGATCTGCCTGCCTCGGACTCCCAAAGTGCTGGGATTACAGGCGTGAGCCAC CACGCCCAGCCTTCCTGGCTAATTTAAAAATTTTTCAGAGACGAGGGTTTTGCCTAGGCTGGACTCACTA TGTTGCCTAGGCTGATCTCGAACCACTGGCCTTAAGTGATCCTCCCACCTCAGCCTCCCAAAGTACTGGG ATTACAGGCATGAGCCGCTGCACATCGCCACAGTTTGATTTTAGTATCCACTTTAAGGTGCAGTTAGTTC TTCCCAGCTCCTCTTTTCCCTATCTCATACAGTGTAGTCACTTCCCTTTCTCCCACTTCTCACCTTCCTA GATTTTGTTTTTCTCTCTCTTACCAAGTTTTGAGTATGTAATACGTCCCAGATCGGTGCTGAACCCCTGG TGTGAGTTAACTTAGCAACTTTTCACGTGGTGTTCTGCAGCCTTCTTACAGATAAGGAAATTCAGAGAGG TGAAGTGTTTTTGCAGAGAGCCACACAATGAGCTAAGAAATTAGAACCCAGGGCAGTTGAACTCCAGAGC CAGGGAACTTAACAGCCCATTCATGCATTCACTCAGGAATTCCCTCTTGAGTGCCTGCTGTGAAGGCAAC CTGGACGCTGTCTCTGCCTTCCTGGGATTGTGGTGTGTGTGGGAGACAGACACGAAACAAAGCAATCTTC TAGGTCAGTGTCTGGCTATGCTGGGTACTCAGAAGGGGGAAGCACTGTGCTGCAAGAGGCCGGCTGTTTC CTCCTCACAAGGGGAGGCCTGCAGTGACATTGCCAGGCCTGAATCTGCCCTGCCATTGGGAGTGTAATTT CCTCACGACTACAAATGCAAATAAATACACACACTGAACATGCTACCCCGCTAGAACTGTGGACAGCTTG TTCACTGCAGTTAAAGGAAGACGGAGGGACACATTTGAGCACGCATGTGTGAGATCCAGCTTGTGGCAAA CCCTGCCATTCTTTAACATCTGTGGGAAGTGAAGCCACCATTACTGACCTCGGAGGAATCCCGGGAGTAG TGGGAAGAAAAGTTGCAGATGTTTGAAAATCAGGCTGCAGGGGCAGTTGGGGTGAGGAGCATGGATGTCT AGGAGCCTGAATCTCAGCGTTGGAAGCCCAGTTCTGATGTAATTTTTTTTTTTTTTTTTTTTTTTGAGAC AGGGTCTCACTTTGTCCCCCAGGCTGGAGTGCAGTGGCACAGTCTCAGCTCACTACAGCCTCATCCTTCC AGGTTCAAGCAGTCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACCACAGGCATGTGTCACCATGCCTTT CTAATGTTTGTATTTTTTTGTGGAGACAGGGTTTCTCACTGTTGCCCAGGCTGGTCTCAAACTCCTGAGC TCATGTGATCCTCCTGCCTTGGCCTTCCAAAGTGCTAGGATTACAGGCGTAAGCCACTGCCCAGCATCCC CACCTTTTTTTTTTTTTTTTTAAATTTGTGGTTTGGTGCAGGTTATTTTACCTCCCCAGGCCTCGGTTTC CTCATCTACTCAAGGGCAATGGCAGATAATCAACCTCACAAATTCCCCGAGGAGTTAGTAGGCTTGTGCC TGCCAGGCTCAGCTGGCTTACAGCAGGTGCTTCATAAGGGGGAGCTATTGCAACGCCTCGGCTGGTTCTA GGCTGCCTAGCTCCAGAGCTAAGAGTCCCAGTGGGTTCATATCCCTTTGAGCATTTATAGGCTTCTCACA GGTCTCCTGGGCTTTCTCAGCCATTCCTCATCTGACCTGAGGAGGTGTGATGTCCTTGCAGGACTCCTCC AGCCCCTCTGAGCTTTTTTTTTTGTTTGAGACAGCATGTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGT GTGATCATGGCTTACTGCAGCCTCCACCTCCTGGGGTCAAGCGATTCTCCCACCTCAGCCTTCCAAGTAG CTGGGACTATAGGTGTATGTTACCATGCTTGAGTAATTTTTAAAATTTTTTGTAGAGATGTGATCTCAGG CTGGTCTTGAACTCCTGGGCTCACCTGGGCTCAAGTAATCCTTGAGCCCAAAGTGTTGGGATTACAGATA TGAGCCACCTTGCCAGGCCCTGAGCTCCTTCTGTCTTCCATGAAGGACACACTATTCCTTGCCTTTTGTC TTTTTTTGTGTGTGTGGCAGGGTCTCTGTTGCCCAGGCTGGGATGTGTTGGTGCAATCTGGGCTTATTGC AACCTCCGCTTCCCGGATTCAAGTGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGGGATTACAGGTGTGC GCAACCACGCCCAGCTAATTTTTGTATTTTTGGTAGACATGGGGTTTCACCATGTTGGCCAGGCTGGTCT CAGCCTCCCGAAGTGTTGGGATTACAGGCATAAGCCACTGTGCCTGGCCACTTTTTGTCTTTTGCATGTT CTATACACCTTGCCGAGAATGTGCTTTCCCTGCCTCCTGGTTATCCCTCAGGTTTCAGCTCTAACATCAC TTCCCCAGGGAAGCCTTACCCTCGCTTTCTTCTGCTATAGGATAATATGAACCACCATCATTGTTACTTG TTTAGTGTCTGCCCTCCCTGCTAGGCAGCAAGGACAGATATCTTGCCTGTCTTAGGTCCCCAGAACCCAG CACAGGGCTTGGAACATGTCAGGTGCTCAAATATTTGTTGAATGAGTCAGTCTGGGCTCGCAGAGGGAGC TGGGACCAGAGTAGAGTGGACACTGAAGCGTATGTAGCAGTTTGCCAGGCGATAGGGAAAGAGACCTTCT TGTAAAGCAAGCAGAGATGAGAGGGAGAAATGAGAATTGCTAAGATTGTTTTGAGCATTTGTTAGGTGGC TTACAGATGCTTTGCTGAACATTTTATTCATGTGATCTTGTTTAAGCCTCTCATTTCCATGAGGGGTTCT CCATTTTTATAGACAAGGAAGGGGACACGTGGAGAGGGGAAGTTACTTTGCCATATCACCCTCTAAGGGA TTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCACCAGGCTAGAGTGCTATGGCGCAATCT CGGCTCACTGCAACCCCCACCTCCCGGGTTCAAGTGATTCTCTTGCCTCAGCCTCCTGAGTAGCTGGGAC TACAGGCATGTGCCACCACATCCGGCTAATTTTTCTATTTTTAGTGGGTACAGGGTTTCGCCATGTTGGC CACATTGATCTCGAACTCCTGACCTCAAGTGAGATTCGCCTGCCTCTGCCTCCTAAAGGCAGTAAGGGAA TTGAACCTAGGCAGTCTGACTCTTAAGAGCTCAAAGACTTAAGCTCTGTCCTGAGTAGCTTCGCTGGTGT ATGGTATAGGGATCAGAAGAGAGCTGGTCTGTATGCCTAGAGGGCATCCTGCAGTGGGCATGTGTGTCTG TGGTCACAGTGGGAGAGAGAGAGGAGGGGGCATCTGTGGCCAGAATGGGGAGGCCTCGAATGCCAGGATG AAGAGTTTGGGCCTATGGTAATGAGAATAGTAATAGCTACCAGTTATTGACTTGCCAGCCACTTGATTGA GTCATTTAACCTCACAACAGTCCTATGGGATAGGTGTTAACTGTTTTCATCCCAGTTTTTCAGATGGGGA AACTGAGACACAGAAGTTGTAGTCAGTTATCCAAAGTGTCGCAGTGAGAAAGTGCTGGAGTTGGGGCTCA GACCCTGTGAGTCAGGCCCCAGAGTTCACTGGGGCCACATGCTCAACCACCATGCCGCCTGCCTGCCGCC GGGGCTGAGCCAGCGGAAACCTGGGTGCTGCTTCTGATGCAGGTGGTCTCCTCTGCTCTCTTCCCCAGCA CCCCCCCAGGCAGCAGCAGCAGTTTTCATCTCTGGATGACAAGCCCCAGTTCCCAGGGGCCTCGGCGGAG TTTATAGATAAGTTGGAATTCATCCAGCCCAACGTCATCTCTGGAATCCCCATCTACCGCGTCATGGACC GGCAAGGCCAGATCATCAACCCCAGCGAGGACCCCCACGTGAGAGGCGGCCTCCCCCACTTCCCGTGCCC CCCACGCCCAGGCCCCTTGCCTGTCTCCTCTCTGGTCCCAACTGCCCCACGTCTATCTGTGCCTCCACCC GCAGCTGCCGAAGGAGAAGGTGCTGAAGCTCTACAAGAGCATGACACTGCTTAACACCATGGACCGCATC CTCTATGAGTCTCAGCGGCAGGTGCGTGGGGACAGGACTAGGGGCGGGGGGCTGGAATTACCTGAGGTCC CCTACCTGTGTTTGGGCCAAAGGAATGGCTCCCAAGGAGGACAGATTCTTTTTTGGGGGGGTTCCATAGA GTTCTGAGGGTTCTCTTGGGACTCTGGAGGAGAAGTGTGAGAGCAGTCCTGCCTTAGGGCAGAAGGATGG ACCTGATCACTAAAAAACACCTACTGTGTGCCTGGCTGGGGGCTCGCCTGTGTGGGGAGAGGGCAGGGAG AAGGCCTGACAGCCCTTCCTCTTGGAAATGCACAGTCCTGAGAAACAGGGTGGGTCCCCAGTGCTTCCTG GAGTGCTCCAGGGGACCGCCCTAGGCCCATGTGAAATGGGCTGTGATCCCCTGATAAATCCTAGTATCAG GGACAAGGATCCAGTCAAGCCAGTGTCAACAAAGAGGGAAGTTATTGACTCCAATGACCATACATCCAGA GGGTCCTGTTTTGGGGCACAGCTAGATCCAGGGGGTCTTCCAGGCAGGAAGTAGAGGGAAGGCGGAAGGC CAGACATGGCACATCCCAGCTATCCCACACCCCCACCTTTATAGAGCTTTCTGGGTAGTCCCACCTAGTG ACATCTGCATACATTTCCTGGGCCACTCCTAGCTGCAGGGGAGACTGAGAAATGTATTAATAATACTTTA GTCCCGGCAGTTGCTGCCTGCGGGAGATTGAGACCTCTGTTAACAGAGGAGGGGAATAGTATACTGGGAA GGCAACCAGGAGCCTCTGCCAGTAGCCCCGAGTCCTGATCCTCAGGGGGCTGGTTGCAGGCTCTTACCCA CGCTAACCTGGACAGTCCTGCCAGGCCCTCAGTACTCAGCACCGCCCACTCACTTGGCACTGGAATGTGC ATTAACTTTTAATTGGCTCCCCACTTAGAAGAAAGCACACATTCATCAGTTTCCCCCACAGCAACGGGAA AGCCAGGCCTGGGAACACATGGAGGAGGGCACCGCCGAGCCGCGAGGAGCTCTGGCCCCGGGGTGTCCCT CAGGGTGCTGGCCAGGCTGCCTTTGTTCCGCTTTACACATGGCCCTGTGTGATCTCATGTCCATCCGTAT GCCAGGGCTGCCCAGAGCCCCAGCCAGACTGCTTGTCAGAGCCCTGCTTGGCTTCTCGCCCTGGATGTCC CACAGCAAACTAATCCTGTCTGAACTTGACCTCGACATCTTCCTCCCAGGCGTGCTCCTTTGCCTCACCT AGTCCGTTTCTCAGTGAAGAGCACCACCATCCACCTGCTTGCCCACACCAGAAACCTCATCTCATCCCTG TCTCCTCCCTCCCCCTTGCTATCCCTTTCTCCCCTCTCATTCCCTCTGTCTGTAGATATTTCTTTTTTTT TTTTTTTTTTACTTTTGAGATGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGATCTTGG CTCACCGCCTCCCTGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCG CCACCACACCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGTCTGGTCTCG AACTCCCTACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAATGGTAGGATTATAGGTGTGAGCCACTG CACCCAGCTGTAGCTACTTCTTTTCTTTTATGTTATTTTTATTTATTTATTTAGAGACGGAGTCCACCTC TGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGA TTCTCCTGCCTTAGCCCCCCAAGTAGCTGGGATTACAGGCGCCCACCACCACACTCGGCTAATTTTTGTA TTTTTAGTAGAGATGGGGTTTCACCACATTGGCCAGGCTAGTCTGGAACTCCTGACCTCAAGTGATCCGC CTGCCTTGGCCTCCCAAAGTACCGGGATTACAGGTGTGAGCCACCGTGCCTAGCCTGTCTGTAGATACAT CTTTAGGAAGTGCTCAGCTGCTCAGCAGCACACTCTGAGACCCAGCCCCATCCTTTCTCTGCTTCACTGT TGTTGGTGAGTTGACCTTCGTGCTCTGCTTGTGGCCTCGTGTTCACAGCATGGCTGCTGCATGTCCAAGC TTCATGGCTGTCTGCAAGGCAGGAAGAAGTAGGGAGTGGGTAGGGCTGGCACCAGCAGCAGTGGTCTCTT CTATCCAGAAAGCAAAAGCAGACTTCCACCAAAATATCTGGCTAAAACTGTGTCCCATGGCCACCTCTGG CTGCAAGGGAGGCCAGGGACCTGAGTGCGTGTCTTTTTGAGGCTCAGGTTAGGGGATTTGGGAGAAGGGA ACTGGGCACTGGTGTGGCCAGCTGACAGGGTCTGCTGCCCCCTAGCACAGCCGACTCAGCTTCCTCAGAC ACATCCACCTGCTCCTCTCCCGCCTCCCTCTGCTACCAAGCTGGGCCTCTGCCCCCTCTCTCCTGGCTTG CTGCAATCAGCCTTGATGACTCCATCCATTTACCTCACTGCAGCCTGAGAGCAATTCTAAAACACAGGTC TGACCACATTGCTCCCTTGAGAAGACTGTCGGCAGGTTACCACTATTCTCAGAGTAAAATCAATGTATCG TTCCCTTTGTTATCTGGGTGCCATCTCCTCTCCCTCCTCATCTTTCCCCACCCCTACCACTGTATGTCCC AGCCCTTCTGGCCTCATGGTCTATCATTCCCTCTGCCTGGAACCCTCCACCCACCCCATCTTTGCGCACT GGTCCTCACCGATGCCCTTCCGTGGTGGAACAGGTGCTTCCTTTGGGCTTCTATCACAGCAACTCGATCC CTCTGGCAGTTCTAAGCAGTCTGGCAGCGTCTTCTTAAAGGCAGGAACCCCAGCATGGCCTGGCCCAGGA CTGGCCTTCAGGAGGACTGTGAATTCATGGAGGTGTTGGAAGCTGGGCAGGATTTGGATGGCTCTCTGTC ATTGCCCAGCATAACCAATTGTGGGACCCCGGTCCCCTCTACACCCCCAGGGCCGGATCTCCTTCTACAT GACCAACTATGGTGAGGAGGGCACGCACGTGGGGAGTGCCGCCGCCCTGGACAACACGGACCTGGTGTTT GGCCAGTACCGGGAGGCAGGTACGTCTGTCCGTGGTTTGGCCCTGTGGTCCCCATTGAAGTGTACACTTT AGTTTTTCTGAGTGTTCTTCCAGGAGCAGCATAGTGCCAGGAAGGTCTAAGGAGCTGGAAGAAGAGCTTT CCAAGCAAGAAAGAGACAAGCCAGGGTTAGGACTCTGGAGGGGGCAGTCTTCCCACTCTGAAGGCCAGAA AGTGTAGTGGCTCAGGGTCTGTGCTCTTAACCCTTTGTTACCAGTTGTCAGGTTTTGGGCAAGTCACTTC CCTTCTCTGAGCCTCAGTTTTCTAATCTCCAGAAGAGGGATTATGACGGTACCTGCATCCAAGGGTCGCT GGGAGGATGCAGTGAAGTCAACGTTCGCTGTGGGTGTGGCCTGTGCAGGAGACCCTGTCTGCCTGGTGCA GTGATCCCCTGGCCCCTCCTCAGGTGCTGTATCCTTCGGGGAGCAGGAGCAGGTGGAAGAACCTTGACAG ACCTGAGTGCGGTGCAAGATTAGAGGGGCCCGGCAAGCCCAGATGAGTGAAAGGAAGGAAGGGTCAAAGA CCAGGAATGAAGAAAATCATTGAGCAGGAATGAGTGCCTGGGAGCGAAGGAGTGAGCCCAGGGAGCAGTG AGTGGGGTCTTCCAGGGAGCTTGTTGGTGTGGGGCCCTGCATGGGGACTACCCTCAGAGTGTCAGCGAGC ACTGATAGGGCCAGGAAGGCATATCTTAACCCTTTGTCTTAGATGCTTGGGGCAAGTTGCTTAACTGCCC TGTGCCTCTGTTTCCTCATTCGTAAGGGGGATGGTAGCCCTTCCCAAGACAGCTGTTGAGGGCAGTCTTG GGGCAGTTGGCAAAGTGCCCTCAGCACAGAGTAAGCGCTCAGGGCCAGGGGTTGGTGTCATGATCGGGGA CTCGCCCTGGGACAGCCCTTCAGCAGGGCCAGACCACGTGGCTGTCCAGAGCCCCCATGGACCAGCATGG CTTGCAGCCTGCTCCTGGACTGTCTACTGCTCACAGCTGGACCAGGCCCTTGGCCCCACATGCTCTAGGA GGGCAAACGCCCTGTGGTGTTTGTCTAAGGTCTAGTGTCATCCGTGCGGAAAAAGATTTCCAGACACCAG GCAGCAAGCTGGGCCCCCGCCAGCTGTGCTGAGCACTGCACCTGTTTTTGCTGAAGGGTTCTCTTGTGAG GGCACCAGGCAGGACCGAGCAAGCCTCATGGGAATCATGGGAGCCGCTGAGCTCTCCACATGGGAGAGCT GGCCGCCTCTGCAAGAATGACTGTCCAGCACTGAGGGTCAGCAGAAGTGTCTGGGCAGCTGCAAATGGGA CTCATGCAGAGGCAGCATGGTGCAGGGTAAGGAGTTGAGTCACATCCACTCTAGACTTCACTTGGCAGGC CACTCACCTTGGTGACGCTGTCTGTCGTCTGTGAAGTGAGAAGAGTGGTGTTCATCATGATAGGTAGTGC CTCCCTGGGCTCTTGACACCAGAGTGCTGTTCTTTTTTTCTTCTCCTTTTTTTTTTTTGAGATGGAATCT CGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCACCTCCTGGGTTCA CGCCATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCATGCCTGGCTAATTT TTTGTATTTTTAGTAGAGGCGGGTTTCACCATGTTAGCCAGGATGGTCTTGATCTCCTGACCTTGCGATC CGCCCTCCTCCACCTCCTAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCTGGCCTTTTTTTTTTTT TTTGAGGTGGAGTCTCACTCTGTCGCCCAGGCTGGAGTACGGTGGCGCAGTCTTGGCTCATTGCAACTTC TGCCTTCCAGGTTCAGGTGATTCTCCTGCCTCAGACTCCGGAGTAGCTGGAATTAAAGGCATGCACCACC ATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCACGTTGGTCAGGCTGGTTTCAAACT CCTGACCTCAAGTGATTCGTTTGCCTTGGCCTCCCAAAGTGCTGGGGATTACAGGCATGAGCCACCGCGC CGGGCCAGCCAAGGTGCTGTTATATGTGCTCTTTAGCCTCGGAGACTGTCATTTCCCCTCACTGCACTGC AGAGCGAGGGCACACCGGGTGAGGTTAGGGCAGGCCCCAGTGGTGTTGCCTCATTGAGGCACCTCCCCCA TCCATGTGAGGCAGGAGAGGCAAGCATTACCATCAACTCTAAAAGCCAGGTAAGAACCTGAGTCAACAAA GGTGAGGTCATGGGCCCAGGCCACATTCTCCTAAGGAGTGGAGCCGAGTCTTTTTATGGCAGTCTGACCC AGAGACAGCTCTCGCTGTTTCCCACCCTTGGCTGTCTTCCCAGGGCTATATGTGGAGTATCAGTGGTGGC ACTGGCAGGGAGTGGCGCCCGGTGAAAAGGAGTGTTAAGAGGAAGCACGTGCCAGGTGTGGTGGCTCACG CCTGTAATCCCAGCACTTCGGGAGGCTGAGGCGGGAGGATTGCTTGAGCCCAGGAGTTTGATACCAGCCT GGGCAACATGGCGAGACCCCCATCTCTAAAAAATTAAAAAATTAGCCAGGCGTGGTGGTGCACACCTGTA GTCCCAGCTACTCAGGAAGCTGAGTGGGAGGATTGCTTGAGCCCAGAGGTTCAAGACTGCAGTGAGCTAT GATTCCACCACCGAACTCCAGTTTGGGTGACAGAGTAAGATCCTGTCTCTGAGACCAACAAGAAAAGAGG TAGCATGTGTCAAGCAAGAGCAGCAGTTCCCACTGGACCTGGAGTTTCCTGGTGCAAATCAGCCTGTGAG TCTGTATTTTCTTTTTTCTTCAAGACGGGGTCTTACTCTGTCACCCAGGTTGAAGTGCAGTGGCATGATC TCGGCTCACTGCAACCTCTGCCTCTTAGGATCAAGTGATCCTCCCACCTCAGCCCCCTGAATAGCTGGGA CCACAGGTGCACGCCACCACACCTGGCTAATTTTTTTTTTGATTTTTGGTAGAGACGGGGTTTCGCTGTG TTGCCCAGGCTGGTCTCAAACTCCTGAGCTCAAGCAGTCCACCTGCCTCACCCTTCCAAAGTGCTGGGAT TACAGGCACGAGCCACTGAGCCTGACAAGTTTGTACTTTTAGCACGTTCCCCTGCCCCTGCCCAGTCCTT CTCACATGGGTGGACCTAGTACCACATTCTGAGAAAGCCTGATTCCAAGGTCCTGTATCAGTCCCTTGGA CCTTCTTTGACCCTCTACAAGACCTTTCTTTCCCTCCTTAACCAGAGCAACTCCTGTTTCTATCTGTTAC ATATGCAGCACAGCCACATCTTGTGTGGATTTGTATTATGTCCATTCAAAAGCATGTGTCAGAAAATACC AGTAAACCTGTATTAAAGTTGGATGTTGAAGTAGTGCTAACCACCCTCAACTCTAACTAAAATATCAACA AGTGGGCTGGGCGTGGTGGCTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCT GAGGTCGGGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTCCTGAAAATGCAAAAATTA GCTGGATGTGGTGGCACATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACC CAGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCCATTGCATTCTGGGCAACAAGAGCAAAACTCCGTC TCAAAAAAAAAAAAAGAAAGAAAATTAGGTAGATCTAGTGGTGCACACCTGGAATCCCAGCTATCTGGGA GGCTGAGGCATAAGAATTGCTTGAACCTGGAAGGTGGAGGTTGCAGTGAGCTCAGATTGCGCCACTGCAC TCCAGCCTGGGTGGCCAAGCCAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGGTAACTGCTGT GTGTAATGTGATCTCCATTAAATTTGTATCTAAAGAGCGGGTTCTGCGGTAAAGAAAGGATTTGGAAAGC ACTGTACTAGAGAGCTCCCTCTGAATAATGTTCCCGGTCTGAGTGCTTGCAGCATTGATCCACAGCGCTG CCCCTAAAGTGTTGGTGTGAAGGTTGTCCCACTCTTCAGGCGGGGCAAAGAGCTTGTCTGAGGGCAATCA CAAACCCCCTTCTGTCTTCTAACTTCGGAGGAAGGGCCCCCTTAACCTGGAGCGGTTCCCTTTGATGGGG AGGTGGGTGTTCACCAGAGGTTTTGTTTGAAGAAAAGGTTTTACTGCCATACATGGGTTAGAGTACTTCT GTAGTCCAGAAGTTGTAAATTAGTGGTCTATGCTGTTATTTGGTTCATAATGATGATTTTTTTTTTTTTT CGAGACAGGGTCTTGCTTTGTAGCCCAGATTGGAGTGCAGTGGCACGATCTCAGCTGCCTGCAGCCTTGA ACTTCTGGGCTGAAGCAATCCTCTGCCTCAGCCTCCCAAGTAGCTGGAACCACAGGCACACATCACCATG CCTGGCTAATGTTTTGATTTTTTTTTTTTTTTGTAGAAGCGAGGCCTCACCATGTTGCTCAGGCTGGTCT CCAACTCCTGGGCTCAAGCGATCCTCCAACGTCAGCCTCTCAAAGTGCTGGGATTACAGGCATGAACCAC CATGCCTGGCCATAGTAATGATTTATGGTTAGAATATTTCTTAAAGGTAATTGAATTAGTTGAAAGCACT TAAATACCAGACAATATCTCACTAAGAGAAAGAAAGAAAAAGGCTAGATTTCTGCTTTCTTTTGAAAAAT CAGATTGGCCTTGCTGGGCAGAGTCAGTCAGTCTGAACATCAGTCTTCCTCTTAAAACAAGCCTGAGCTT TCCTGTCTGCCTGCCAGCATGCTGCAGGTCACCCACAGGGCTGAACTGTCCCCCTGTACTGCCCACTCGG CTAACCATTGCCTCCTCCCCTCCTAGGTGTGCTGATGTATCGGGACTACCCCCTGGAACTATTCATGGCC CAGTGCTATGGCAACATCAGTGACTTGGGCAAGGGGCGCCAGATGCCTGTCCACTACGGCTGCAAGGAAC GCCACTTCGTCACTATCTCCTCTCCACTGGCCACGCAGATCCCTCAGGGTGAGGATGCATGCCCTGTACC TTGCACATGTGCAGACCAATGTCACACCCCTGTCCAGGCCTCAGCTCTTTTGCCTGCCTTCTGGGTGGAA TTCTGGGTTGGTGACACCACTAGAGCCCTGGTCTGTGCTCCAGACTTCTTCTTCTTATTTTTTTCTTTTT TGAGACGGAGTCTTGCACTGTTGCCCAGGCTAGAGTGCAGTGGTGCTATCGCAGCTCACTGCAGCCTCCT TCTCCCAGCTTCAAGCAATTCTCCTGCCTCAGCCTCCCGATTAGCTGAGACTACAGGTGTGCACCACCAC GCCCAGCTAATTTTTGTATTTTTAATAGAGACAGGGTTTCACCGTGTTGGCCAGGCTGGTCTCAAACTCC CGGCCTCAGGTGATCCACCCGCCTCAGCCTCTCAAAGTGCTGGGATTACAGGCGTTTAAGCCATTGTGCC CAGCCCACTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTCTGAGACGGGGTTTCACTCTCGTCAG CCAGGTTGGAGTGCAATGGTGCAATCTCGGCTCACTGTAACCTCCACCTCCCAGGCTCAAGTGATTCTCC TGCCTTAGCCTCCTGAGTAGCTGGGATTATGGGCATATGCCATTGTGCTTGGCTAAATTTTTGTATTTTT TGTAGAGATAAGGTTTCACCATTTTGGCCAGGCTGGTCTTGAACCTGAGTTCAAGTGATCTGCCCACCTT GGCCTCTCAAAGTGCTGGGATTACAGATGTGAGCCACTGCACCTGGCCTGTGTTCCAGACTTTGAATGCA CCTCTTGTCTGGGACCCTTCAGAAGAGGGCTCTGTTGCTGTCCCCACCCCATTCAGGGGCCTGAAGCCTG TGTGACCACACTCTGGATTTCCCAACCACATGCCTACTGCATTTGTCTGCTCACAAACATAGCCAACGTG TGCACCAGGTTCCACTGTGCCAATGCTTCACGTTCATCATCTAATAAGGACCCTCATTGTGGCCATGGGG ACAGAGGTTATTATTTGCTCTTGTTCCTGTTTTCAAGAGCAGGATGCCCGTGTTTTGTGTGTGTGTGAGA GACAGCAAGTGAATGGGAAAAAAAAAAGTGCAGGAGCCTGGCCAACATGGCAAAGCCCTGTCCCTACTAA ACATACAAAAATTAGCTTGGCATGGTGGTGCACACCTGTAATCCTAGCTACTCAGGAGGCTGAAGCAGGA GGATTGCTTGAACCTGGGAGGCAGAGTTTGCAGTGAGCTGAGATCGTGCCATTGCACTCTAGCCAAAGTG AGATCCTGTCTCAAAAAAAAAAAAAAGGAAATTGAAGTCAAAGAGGGAAGTCACTCGCTAACGGTCATGT GGCACAGAGGGAGAGGAGCAGGGACTCAAGTCATTGACTGTGTACCTCCAGAGCCTGGGTTCTTGGCCCT GACCTTTGTCTGCCTCAGTCCTCAGAGTCAAGTAAGCTTCCCCAAAGCTTACCGTAGGTGCCCTGAAGTC CCTTCCCTTATAAGAGCTTTTTTGGGAAGCAAACCCACTGGGTGCCAGGCCTGCACCCTCATAGTGTGGA GAACAAGGAATCGGAGCCCCTTCCTGTCCTCCGGGGCCTGTAGCCTGATCTAGGGTTGGTCTGGGCCCTG GCTTCTTTGCCCTAGGGCAGCTGAGATGCATGAGTTTGTGTCTCTCCAGGCCTCAGCACTGTGCCCAGCA CAGCAGGAGGCTCCACACCCCTTAGCTCATAGTGTTCTTTTGTTGAGGAACAAGAAGCAGTTTGAGCCTC TTAGGTGGGAGGTGGGCAGGGAAGCTTTCTCAGAGGAGGGGGCATTTAGGGGGCATTTGAGCTAAAGGTA ATAGGGTTTCCACAAGGCTGGGGCGTGGCCCTAACCTTCCCTCTGGGTCCCTGCTAAGTCACTTCAAATA CACGAAGTTCCTGCCATGTGCCGGTGCCACTCCAAGTGCAGGGAACAAAAGCAACGCAAACCTCAGCCCT CCTGGTGCTGCCATTGTGGTGGGGGAGACGGACAGTAACAGAGATGGAGAGGGAACTCCTGGAGTATATG AGGGTGGGGGTCCTGTAGGGAGCAGCCAAGCCAGCCGGGTGTGGTGCACTGTAGGGGTGGCTGGGGTCCG TCACTGGAGTGACACTGAAGTATGGACCAGAGGATGTGAGGGGGGAGCTGTGTGGTGTCTTGAGGCAGGT GTGAGCCTGGCGTGTTTGAGGAGCTGGGAGGAGCCCAGAGGGGCAGGTGTGGAGTGAGCAGGTGTGGAGT GAGCGGGTGTAGGGTGAGCAGGTGTGGGGTGGTTGGAGGTAAAGTCCAGGAGGTGGTGGGTGGGGGTGCA GATGGTGCAGGTTGGGTGGGGCCTCAAGGCCTTTGCCTGTTGCAGGGATGTCGACTTTTACTCAAAGTGG GACAGGAGCCGTGGGTGGGGAGGAGTCTGCTCTTCCTTGGCCTGGCTCACCTCTTCATGGAATCCGCGGG CTGCCCTGTGGATAAGGGATTGGGCAGTGTGTGAAGGGCTAGTAAGGAGGCTGCTCAGTAACTTGGGCTT GACCAGGGTGGTGCAGAGGAGGAGGTAAGAGGGGTTAGGTTCTGAAGGTGGAGTAGATGTGGAGAATGGC GGGAAGTTTGGCTTGGAGATGATACTGGACTCTTCAGCCTGAGCAGTTGGAAGGGTGGAGTTGCTTTCAG CTGAGCAAGAGGAGACCTGGGTGGGCAGATGCTGGGGGGCATCAGGAGCTGAGGTGTTTCCTTTCCCCTT GAAGCCTGGTGACTGCTGGCCTGAGCCACGCTTGAGCCGTGGGTCATGTGAGTGTGAATGAGTGTGAGTG CATGTGAGTCTCCGCCCCTGCTCACCACCCTCTCATCCCCTGCAGCGGTGGGGGCGGCGTACGCAGCCAA GCGGGCCAATGCCAACAGGGTCGTCATCTGTTACTTCGGCGAGGGGGCAGCCAGTGAGGGGGACGCCCAT GCCGGCTTCAACTTCGCTGCCACACTTGAGTGCCCCATCATCTTCTTCTGCCGGAACAATGGCTACGCCA TCTCCACGCCCACCTCTGAGCAGTATCGCGGCGATGGCATTGGTATGGGCTCTGCTGGCTGCTCCCCACC CCGCTGGGATCATCTCCTTCCCTCCCCAATCCTGCCACCTTCCTGCCACCCCTACCCTCCTTCCTGGTTC TCGTCCTGTGTCCTGTGGCGTCTGGCACTTGGTCAGCCACAGGAGTTGAGGTCCTGAGCACTCAGCCTTG CTCTCTGTCCTCTCCCTGCTCGTCCCCTTGGCCTCGTGCATGTTCCTTATCTCAGCCCTGGCCTGACCTG CCTTCTCTGTGTCCCCACAGCAGCACGAGGCCCCGGGTATGGCATCATGTCAATCCGCGTGGATGGTAAT GATGTGTTTGCCGTATACAACGCCACAAAGGAGGCCCGACGGCGGGCTGTGGCAGAGAACCAGCCCTTCC TCATCGAGGCCATGACCTACAGGTGCCTGCCGCTCCCCCCGTCAGCACCCCCACAGCACTGACAGCCACC GTAGCATCTTCCTCATATCGATCACTGTCTCCAAAACATGGCCTTATCACCTGATGTTGCATCTCCCCCT TGCCTTTATTCCGTTTCCACTCCTCCTTCCCTAGTTCATCCCCCATCCTCCCTCCTGACCCCCACTCCAG GGAGCCCACACTGACCTGGGGCCCCTTGCCCCTGTGCAGGATCGGGCACCACAGCACCAGTGACGACAGT TCAGCGTACCGCTCGGTGGATGAGGTCAATTACTGGGATAAACAGGACCACCCCATCTCCCGGCTGCGGC ACTATCTGCTGAGCCAAGGCTGGTGGGATGAGGAGCAGGAGAAGGCCTGGAGGAAGCAGTCCCGCAGGAA GGTGAGGGTGCCCCGCCCGGGAGGGTGTGCTGGGGGCTGCTGCGGCCTGCAGAGCTTGGGAAGGATTTGT GGAACACCGAACTGGGAGGCTCAGGGATAACCCCAGTGATGTCTCAGATGTGGCCTGTGGAGCCAGGCTG CTGGGGCCATGTGTGTCCTGGCTCTGTGTCCTTGGCATGTTGCCCTCCACTTCCTTGTCTTTGAAAGGGG ATGCTGGTGGTGCCCATTTCAGAAACTGGTTTGAGACTGGGCATGGTGGCTCACACCTGTAATCCCAGCA CTTTGGGAGGCCGAGGTGGCAGATCACTTGAGGTCAGGAGCTTGAGAACAGCCTGGCCAAACATGGTCAA GCCCTGTCTCTACTAAAAATACAAAAATTAGGGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTT TGGGAGGCCAAGGCGGACAGATCACCTGAGGTCGGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACC TCGTCTCTAATAAAAATACAAAAATTAGCCGGGCATGGTGCCGGGTGCCTGTAATCCCAGCTACTTGGGA GGCCGAGGCAGGAGAATTGCTTGAACCTGGGAGGTAGAGGTTGCAGTGAGCTGAGATCGTACCATTGCAC TCCAGCCTGGGCAACGAGAGCAAGACTCCATCTCAAAAAAAAAAATTAGCCAGGCGTGGTGGTGCGTGCC TGTAGTCCCAGCTACTCAGGAAGGTGAGGCAGAAGAATCGCTTGAACCCGGGAGGTGGAACTTGCAGTGA TTGGAGATGGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTATCTCTTAAAAAAAAAAAAAAGC TGGTTTGAGGATTAGGTGGCAAACCGTGGTGGAGTGTACATGCCCTGCCCAGAGTCAGTGTGCCACCCTC CCTGGCCCGGTCATTAGGACCCAGGGCCCGTGCAGCCCAGTGGTGAGGGCAGCACCCGGCATAGGGCAGC ACCGTGTGTCCTGTCCCTGCCCTTCTCTGTGCCTCAGTTTCCTCATTGCTTAGCTGTCTACCTCTTAGGG CTGCTGAAAGCCTTAAATGATTCCACACACTTGGATAGCACCTGATCCCTGCTGGGATTTGAGGGTTTTC ATTACACTTCTGCTAGGATAATCATTTCCATTGTCGAGGTGGGAACACAAAGGCTTGGAGTGGTTAATTC CTTGCCAAGGCCCCGCAGGAGGAAGCAGGGTCCTGCATGGGAGGCCGGCTAGCCTGCCCACTGCCCCATG TCCCCACAGGTGATGGAGGCCTTTGAGCAGGCCGAGCGGAAGCCCAAACCCAACCCCAACCTACTCTTCT CAGACGTGTATCAGGAGATGCCCGCCCAGCTCCGCAAGCAGCAGGAGTCTCTGGCCCGCCACCTGCAGAC CTACGGGGAGCACTACCCACTGGATCACTTCGATAAGTGAGACCTGCTCAGCCCACCCCCACCCATCCTC AGCTACCCCGAGAGGTAGCCCCACTCTAAGGGGAGCAGGGGGACCTGACAGCACACCACTGTCTTCCCCA GTCAGCTCCCTCTAAAATACTCAGCGGCCAGGGCGGCTGCCACTCTTCACCCCTGCTCCTCCCGGCTGTT ACATTGTCAGGGGACAGCATCTGCAGCAGTTGCTGAGGCTCCGTCAGCCCCCTCTTCACCTGTTGTTACA GTGCCTTCTCCCAGGGGCTGGGTGAGGGCACATTCAGGACTAGAAGCCCCTCTGGGCATGGGGTGGACAT GGCAGGTCAGCCTGTGGAACTTGCGCAGGTGCGAGTGGCCAGCAGAGGTCACGAATAAACTGCATCTCTG CGCCTGGCTCTCTACCACCTCTGGTCTTTGTTTCCTGGAGTTTGGGGGTGATTTGAGGCCACCCCCAGCT TCTCCACCTTAGATAAATAAGGTCAAGGCTCTTGAGATACCTACTTCCCCCGGAAGCTTGCGCAAGCTGG AAGGTTAACTTCAGCAGACAGGATGGGGGTGGGGGGGTCCTCCAGAGATGGTCTCCTGCTCTCTCACAGA ATGGGAGAAGCCTGCTGTCCAGCAGAGTGATGGGGAGCCCAGTGGAGCTAGCCCTGCCCAGCAGGGGTGC AGGGGAGCGTCCAGGATGAAGGTCAGGGTGTGGCCAAGCCCTGCTCCCCACCACTCCAGGGCCCCACAGA TGCAAAAACAACCCCAGGCCTCAGAGTGGGGAGTGCATGTTTTTCAAAAACAAAAAGTAGGCAAAAACAG TCCACCACCCCATCTTTCCTGCCCAGGCCCCTGGCTGGGGGAGGCCAAGGAGTGGCTTAAGTTGTCCAGC TTCTGGGCCCTCCTCCCTCCCATCAAGACCTGGAAGGAGGGGCTGAGCCAGGGGCCGGCCCCAGAGGCCC AGGCCAGGTCAGCACCTCCGCCCTCCCCAATGAGAGTCAGCACTGGAGCCTTGGGTCTTGCAGTTGTTTC CAGAGCCGAATGCTGGCCTGGGGGCCCAGGGGCCGTACCAGCAGCAGGTTGCGGAAAGCACAGTGGTCCG CAGTGCGGTCTGCTGGCCAGGCTGTGAGGAAGCCTGGGTGGGCCTGGGGCACCAGGCCCAGGGCTCGGAT GCAAAGGCCAGTGTAGACGTCCTCAAAGGGGAAGGGTGCCACACGGGCTGCCGCCCGCAGCAGCCAGGGT GCCAGGCGCCCGGCAATGACGTAGCCACCCCCGCTTGCATAGGCTGGGTAGCCACCTTCGAAGAAGGACT CGGGCACATAGAAGGGTCCTCCTGGCTTCCGGAGAGGCATGGCCTGGGTAAAGACCTCACCCAGGTAGAG GCTTCGGGCCGAGGCAGGTGGCAGGGCCCGCAGGTGAGCCAGCAGGGCAGGGGTGTGTACAAAGGCATCG TCCTGAGCTCGCAAGACAAAACTCACGGTGGGGCAGTGGCGGCCCAGCCAGGCCAGCAGCAGCAGGTCTT TGAGCGTCTGGTTGAATGGGACGTCGAGGAAGTCCCAGAGCAGCAGGTCACTGTAGCGACGGCTCTCCCA GGCCACTAGTGAGTCTAGGTCAGGCCCCGCCTCACCCACCGGAGACCCTAGCAGGAAGAGCAGCCGGATC CCTGGAGCTGGACTGCCCCACGTCTCTCTCACGGCCTGTCGTTCTGCAAAGCGCCCTGGTTCTGACTTGA CGGCCAACAGCAGGTAGGGGACATCAGTATCTGAGCAGCTGGAGACTTGGCTGCCACCACCTCCAGGCAG CCACTGTGGGAAGCTCCGGCAGGCTGCTGACAGCAAGAAGCGGCGGAGGTCCTTGGGGTAGGAGGCGAAG TCAGGGATCTCGGTGGCGGCGGCGGCCCCCCAAGCCTGGCAGCCCCCCGTTTCAGTGCTGTCCCCACTGG GCAGGGACCCCAGCCGCCACTGCTGCTGGTTCCAGTAAGCAAAGGGCAGCGGGATAGTCTGGCCCAGGCG GGTGGAGAGGTTGGCAGGTAGGGTGGGCTCAGGGTTGGCTGGCGTGGGGCTTGGCGGGGTGCCCCGAGGG CTGGGGTAGGCCTTGCTGAGCCGGGACTCGGATGTCCACTCGATGTACACTTTGAGGCCCAGGAGTGTGA GCAGTGCTGACAGGCAGAGAAGGCACTTGGGGCAGCGCATGACCCGGCCCAGGGAAGGGGCGGCCGCGGG AGCTACAAGGGAGCCACAGGGGAGCCACGGAGGCCATTGGGGTGTGGGGATGGGCCTCCAGAGAGGGCCC AGCCAGGCCCCAGGCAGACAGCTTCACAATCTCCCATAGTCCCCGCCAACCCCCATAACAGATTCTCTCG GTCCCAGATCCTAAACAGCTCCCCTGACCCAGGGACCTCGTTGGTCCTTATTCCTAG
mRNA transcript
>gi|258645170|ref|NM_000709.3| Homo sapiens branched chain keto acid dehydrogenase E1, alpha polypeptide (BCKDHA), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA CTACGTGAGTGCCGGACCGCTGAGTGGTTGTTAGCCAAGATGGCGGTAGCGATCGCTGCAGCGAGGGTCT GGCGGCTAAACCGTGGTTTGAGCCAGGCTGCCCTCCTGCTGCTGCGGCAGCCTGGGGCTCGGGGACTGGC TAGATCTCACCCCCCCAGGCAGCAGCAGCAGTTTTCATCTCTGGATGACAAGCCCCAGTTCCCAGGGGCC TCGGCGGAGTTTATAGATAAGTTGGAATTCATCCAGCCCAACGTCATCTCTGGAATCCCCATCTACCGCG TCATGGACCGGCAAGGCCAGATCATCAACCCCAGCGAGGACCCCCACCTGCCGAAGGAGAAGGTGCTGAA GCTCTACAAGAGCATGACACTGCTTAACACCATGGACCGCATCCTCTATGAGTCTCAGCGGCAGGGCCGG ATCTCCTTCTACATGACCAACTATGGTGAGGAGGGCACGCACGTGGGGAGTGCCGCCGCCCTGGACAACA CGGACCTGGTGTTTGGCCAGTACCGGGAGGCAGGTGTGCTGATGTATCGGGACTACCCCCTGGAACTATT CATGGCCCAGTGCTATGGCAACATCAGTGACTTGGGCAAGGGGCGCCAGATGCCTGTCCACTACGGCTGC AAGGAACGCCACTTCGTCACTATCTCCTCTCCACTGGCCACGCAGATCCCTCAGGCGGTGGGGGCGGCGT ACGCAGCCAAGCGGGCCAATGCCAACAGGGTCGTCATCTGTTACTTCGGCGAGGGGGCAGCCAGTGAGGG GGACGCCCATGCCGGCTTCAACTTCGCTGCCACACTTGAGTGCCCCATCATCTTCTTCTGCCGGAACAAT GGCTACGCCATCTCCACGCCCACCTCTGAGCAGTATCGCGGCGATGGCATTGCAGCACGAGGCCCCGGGT ATGGCATCATGTCAATCCGCGTGGATGGTAATGATGTGTTTGCCGTATACAACGCCACAAAGGAGGCCCG ACGGCGGGCTGTGGCAGAGAACCAGCCCTTCCTCATCGAGGCCATGACCTACAGGATCGGGCACCACAGC ACCAGTGACGACAGTTCAGCGTACCGCTCGGTGGATGAGGTCAATTACTGGGATAAACAGGACCACCCCA TCTCCCGGCTGCGGCACTATCTGCTGAGCCAAGGCTGGTGGGATGAGGAGCAGGAGAAGGCCTGGAGGAA GCAGTCCCGCAGGAAGGTGATGGAGGCCTTTGAGCAGGCCGAGCGGAAGCCCAAACCCAACCCCAACCTA CTCTTCTCAGACGTGTATCAGGAGATGCCCGCCCAGCTCCGCAAGCAGCAGGAGTCTCTGGCCCGCCACC TGCAGACCTACGGGGAGCACTACCCACTGGATCACTTCGATAAGTGAGACCTGCTCAGCCCACCCCCACC CATCCTCAGCTACCCCGAGAGGTAGCCCCACTCTAAGGGGAGCAGGGGGACCTGACAGCACACCACTGTC TTCCCCAGTCAGCTCCCTCTAAAATACTCAGCGGCCAGGGCGGCTGCCACTCTTCACCCCTGCTCCTCCC GGCTGTTACATTGTCAGGGGACAGCATCTGCAGCAGTTGCTGAGGCTCCGTCAGCCCCCTCTTCACCTGT TGTTACAGTGCCTTCTCCCAGGGGCTGGGTGAGGGCACATTCAGGACTAGAAGCCCCTCTGGGCATGGGG TGGACATGGCAGGTCAGCCTGTGGAACTTGCGCAGGTGCGAGTGGCCAGCAGAGGTCACGAATAAACTGC ATCTCTGCGCCTGGCTCTCTACCAAAAAAAAAAAAAAAAAA
Protein
>gi|11386135|ref|NP_000700.1| 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial isoform 1 precursor [Homo sapiens] MAVAIAAARVWRLNRGLSQAALLLLRQPGARGLARSHPPRQQQQFSSLDDKPQFPGASAEFIDKLEFIQP NVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGT HVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLA TQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYR GDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDE VNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQL RKQQESLARHLQTYGEHYPLDHFDK
Neutral mutations
Disease causing mutations
Several disease causing mutations are reported in OMIM. Following table summarize the reported allelic variations:
| ID | Variant type | Mutation detail | Cause | Severity |
|---|---|---|---|---|
| 1 | mutation | TYR393ASN | MSUD type 1A | classic |
| 2 | deletion | 8-BP DEL, 887-894 | MSUD type 1A | classic |
| 3 | mutation | GLY245ARG | MSUD type 1A | intermediate |
| 4 | mutation | PHE364CYS | MSUD type 1A | intermediate |
| 5 | mutation | ARG220TRP | MSUD type 1A | classic |
| 6 | mutation | GLY204SER | MSUD type 1A | classic |
| 7 | mutation | THR265ARG | MSUD type 1A | classic |
| 8 | mutation | CYS219TRP | MSUD type 1A | classic |
| 9 | deletion | 1-BP DEL, 117C | MSUD type 1A | classic |
References
branched chain keto acid dehydrogenase E1, alpha polypeptide (BCKDHA)
RefSeqGene of branched chain keto acid dehydrogenase E1, alpha polypeptide (BCKDHA)
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial isoform 1 precursor (Homo sapiens)
