Resource data

From Bioinformatikpedia
Revision as of 11:45, 13 April 2011 by Andrea (talk | contribs) (Pathway info)

Disease info

  • HGMD - "Human Gene Mutation Database", collects sequence and mutation information, links to other resources, e.g. OMIM
  • OMIM - "Online Mendelian Inheritance in Man" maintained at NCBI, has many links to related data (gene, protein, literature, etc.)
  • KEGG Disease - The KEGG DISEASE database is a collection of disease entries capturing knowledge on genetic and environmental perturbations of the KEGG pathways (see Pathway section).

Protein sequence info

  • Uniprot - central sequence repository (mainly used in Europe) with data from Swissprot and Trembl (and many links to related data)
  • NCBI Protein - central protein sequence search interface of NCBI, includes data from GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB

Structure info

  • PDB - "Protein Data Bank", central repository for protein structures
  • PDBsum - structural annotations of PDB structures (analysis of interactions between chains and with small molecule ligands)
  • SRS 3D - quick access to related structures (based on HSSP): search for Uniprot identifier of your protein -> get a list of related structures; click on a structure -> view the sequence aligned to the related structure

Pathway info

  • KEGG - "Kyoto Encyclopedia of Genes and Genomes" collects maps of metabolic pathways etc.
  • MetaCyc - database of nonredundant, experimentally elucidated metabolic pathways (from literature), contains pathways involved in both primary [def] and secondary [def] metabolism, as well as associated compounds, enzymes, and genes.