Resource data

Disease info

• HGMD - "Human Gene Mutation Database", collects sequence and mutation information, links to other resources, e.g. OMIM
• OMIM - "Online Mendelian Inheritance in Man" maintained at NCBI, has many links to related data (gene, protein, literature, etc.)
• KEGG Disease - The KEGG DISEASE database is a collection of disease entries capturing knowledge on genetic and environmental perturbations of the KEGG pathways (see Pathway section).

Protein sequence info

• Uniprot - central sequence repository (mainly used in Europe) with data from Swissprot and Trembl (and many links to related data)
• NCBI Protein - central protein sequence search interface of NCBI, includes data from GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB

Structure info

• PDB - "Protein Data Bank", central repository for protein structures
• PDBsum - structural annotations of PDB structures (analysis of interactions between chains and with small molecule ligands)
• SRS 3D - quick access to related structures (based on HSSP): search for Uniprot identifier of your protein -> get a list of related structures; click on a structure -> view the sequence aligned to the related structure

Pathway info

• KEGG - "Kyoto Encyclopedia of Genes and Genomes" collects maps of metabolic pathways etc.