Secondary Structure Prediction BCKDHA

3. Prediction of transmembrane alpha-helices and signal peptides

Transmembrane topology and signal peptides are features that are likely to be conserved during evolution.

Phobius

Phobius predicted a signal peptide with about 90% probability at the beginning of the sequence. The predicted signal peptide is 34 amino acids long. The rest of the amino acid is a non cytoplasmic protein sequence. No part of the protein is predicted to be transmembrane spanning.

sp|P12694|ODBA_HUMAN (BCKDHA)
Signal	1	34
Region	1	16	N-Region
Region	17	25	H-Region
Region	26	34	C-Region
TOPO_DOM	35	445	non cytoplasmic

sp|P02945|BACR_HALSA
TOPO_DOM	1	22	NON CYTOPLASMIC.
TRANSMEM	23	42
TOPO_DOM	43	53	CYTOPLASMIC.
TRANSMEM	54	76
TOPO_DOM	77	95	NON CYTOPLASMIC.
TRANSMEM	96	114
TOPO_DOM	115	120	CYTOPLASMIC.
TRANSMEM	121	142
TOPO_DOM	143	147	NON CYTOPLASMIC.
TRANSMEM	148	169
TOPO_DOM	170	189	CYTOPLASMIC.
TRANSMEM	190	212
TOPO_DOM	213	217	NON CYTOPLASMIC.
TRANSMEM	218	237
TOPO_DOM	238	262	CYTOPLASMIC.

Polyphobius

OBDA_HUMAN (BCKDHA)
TOPO_DOM	1	445	Non cytoplasmic