Talk:Glucocerebrosidase homology modelling

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Revision as of 14:01, 17 June 2011 by Andrea (talk | contribs)

Very nice report!

Some comments:

  • an RMSD of 1.9 A between the apo and a complex reference structure seems higher than expected for me. Do you know where the big differences are?
  • It's interesting that Modeller messed up the secondary structures for the mixed templates. Are the templates so different? Didn't it manage to align them in 3D?
  • Did you notice that the TM-score of the combined model is also better than the the on of the 2E4T model alone?
  • Modeller also gives a numeric score for its models (DOPE). Did you check that? Does that score correlate with the model quality?
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