Task 8: Sequence-based mutation analysis

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Lab journal task 8

Mutation selection

<figtable id="mutations">

Table 1: List of the 10 selected mutations from HGMD and dbSNP.

mutations
nucleotide change	amino acid change
	Val53Met
	His63Asp
	Arg67His
	Met97Ile
	Asn130Ser
	Glu168Gln
	Leu183Pro
	Thr217Ile
	Cys282Tyr
	Arg330Met

</figtable>

Mutation analysis

Val53Met <figtable id="Val53Met">

Table 2: Summary of the analysis of Val53Met.

pyhsicochemical properties	pymol visualisation	secondary structure	substitution matrix	PSSM	MSA	SIFT	Polyphen2	MutationTaster	SNAP

</figtable>

His63Asp <figtable id="His63Asp">

Table 2: Summary of the analysis of His63Asp.

</figtable>

Arg67His

<figtable id="His63Asp">

Table 2: Summary of the analysis of His63Asp.

</figtable>

Met97Ile

<figtable id="His63Asp">

Table 2: Summary of the analysis of His63Asp.

</figtable>

Asn130Ser

<figtable id="His63Asp">

Table 2: Summary of the analysis of His63Asp.

</figtable> Glu168Gln Leu183Pro Thr217Ile C282Y Arg330Met