Supplementary data normal mode glucocerebrosidase

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Anisotropic Network Model

Mode 6 Mode 7 Mode 8 Mode 9 Mode 10
Figure 26: Normal Mode 6 calculated with ANM
Figure 27: Normal Mode 7 calculated with ANM
Figure 28: Normal Mode 8 calculated with ANM
Figure 29: Normal Mode 9 calculated with ANM
Figure 30: Normal Mode 10 calculated with ANM
Inter Distance Analysis
Figure 31a: Distance Matrix

Figure 31b: Deformation Energy

Overall energy: 107191.169783064
Figure 32a: Distance Matrix

Figure 32b: Deformation Energy

Overall energy: 112430.078797944
Figure 33a: Distance Matrix

Figure 33b: Deformation Energy

Overall energy: 138939.176046648
Figure 34a: Distance Matrix

Figure 34b: Deformation Energy

Overall energy: 156195.358655472
Figure 35a: Distance Matrix

Figure 35b: Deformation Energy

Overall energy: 154660.33882932
B-factors/mode fluctuations
Figure 36: B-factors/mode fluctuations
Figure 37: B-factors/mode fluctuations
Figure 38: B-factors/mode fluctuations
Figure 39: B-factors/mode fluctuations
Figure 40: B-factors/mode fluctuations