Sequence-based predictions TSD

Thor: He's my brother

Natasha Romanoff: He killed 80 people in 2 days

Thor: ...He's adopted

If not noted otherwise, the sequence for all predictions is the HEXA Reference sequence. A protocol for this task can be found here.

Signal peptides

Proteins: P02768, P11279, P47863
SignalP employs 3 main scores for the prediction of signal peptides, C, S and Y. The S-score stands for the actual signal peptide prediction, with high scores indicating that the corresponding amino acid is part of a signal peptide, and low scores indicating that the amino acid is part of a mature protein. The C-score is the cleavage score, which indicates the best cleavage cite when significantly high. (When a cleavage site position is referred to by a single number, the number indicates the first residue in the mature protein.) Y-max is a derivative of the C-score combined with the S-score calculated to give a better cleavage site prediction than the raw C-score alone.
There are two additional scores reported in the SignalP output, namely the S-mean and the D-score. The S-mean is the average of the S-score, ranging from the N-terminal amino acid to the amino acid assigned with the highest Y-max score. The D-score is implemented as a weighted average of the S-mean and the Y-max scores.
For non-secretory proteins all scores are supposed to be very low.

figtable id="tbl:signalp">

	Table : Signal peptide predictions.

</figtable>

The <xr id="tbl:signalp"/> shows the identity and e-value distribution from BIG80 and BIG.

GO terms

GOpet

<figtable id="tab:gopetgo">

GO-Term ID	Type	Confidence	GO-Term description
GO:0003824	Molecular function	97%	catalytic activity
GO:0004563	Molecular function	96%	beta-N-acetylhexosaminidase activity
GO:0015929	Molecular function	96%	hexosaminidase activity
GO:0016787	Molecular function	96%	hydrolase activity
GO:0016798	Molecular function	96%	hydrolase activity acting on glycosyl bonds
GO:0004553	Molecular function	96%	hydrolase activity hydrolyzing O-glycosyl compounds
GO:0016799	Molecular function	77%	hydrolase activity hydrolyzing N-glycosyl compounds
GO:0046982	Molecular function	61%	protein heterodimerization activity

Table TODO: </figtable>