Difference between revisions of "Structure-based mutation analysis ARSA"

From Bioinformatikpedia
(→‎Preparation)
(→‎Visualization with Pymol)
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[[File:arsamodel.png | 200px | center | thumb | Pymol visualization of ARSA (with closed gaps). The active site is depicted in yellow, metal-binding site in blue, substrate binding sites in green and missense mutations in red.]]
  
[[File:arsamodel.png | 200px | center | thumb | Pymol visualization of ARSA (with closed gaps). The active site is depicted in yellow, metal-binding site in blue, substrate binding sites in green and missense mutations in red.]]
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{| border="1" style="text-align:left; border-spacing:0;"
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| '''Nr.'''
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| '''mutation'''
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| '''position'''
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| ''' Pymol image '''
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| ''' Description '''
  +
| ''' Effect on function '''
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|-
  +
| 1
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| Asp-Asn
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| 29
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| [[File:arsa29.png | 200px | center | thumb ]]
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|-
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| 2
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| Pro - Ala
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| 136
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| [[File:arsa136.png | 200px | center | thumb ]]
  +
|-
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| 3
  +
| Gln-His
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| 153
  +
| [[File:arsa153.png | 200px | center | thumb ]]
  +
|-
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| 4
  +
| Trp-Cys
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| 193
  +
| [[File:arsa193.png | 200px | center | thumb ]]
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|-
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| 5
  +
| Thr-Met
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| 274
  +
| [[File:arsa274.png | 200px | center | thumb ]]
  +
|-
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| 6
  +
| Phe -Val
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| 356
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| [[File:arsa356.png | 200px | center | thumb ]]
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|-
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| 7
  +
| Thr-Ile
  +
| 409
  +
| [[File:arsa409.png | 200px | center | thumb ]]
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|-
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| 8
  +
| Asn-Ser
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| 440
  +
| [[File:arsa440.png | 200px | center | thumb ]]
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|-
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| 9
  +
| Cys-Gly
  +
| 489
  +
| [[File:arsa489.png | 200px | center | thumb ]]
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|-
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| 10
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| Arg-His
  +
| 496
  +
| [[File:arsa496.png | 200px | center | thumb ]]
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|-
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|}
   
 
==== SCRWL ====
  
==== SCRWL ====

Revision as of 08:12, 30 June 2011

Preparation

Visualization with Pymol

Pymol visualization of ARSA (with closed gaps). The active site is depicted in yellow, metal-binding site in blue, substrate binding sites in green and missense mutations in red.
Nr. mutation position Pymol image Description Effect on function
1 Asp-Asn 29
Arsa29.png
2 Pro - Ala 136
Arsa136.png
3 Gln-His 153
Arsa153.png
4 Trp-Cys 193
Arsa193.png
5 Thr-Met 274
Arsa274.png
6 Phe -Val 356
Arsa356.png
7 Thr-Ile 409
Arsa409.png
8 Asn-Ser 440
Arsa440.png
9 Cys-Gly 489
Arsa489.png
10 Arg-His 496
Arsa496.png

SCRWL

BLA


repairPDB arsa_model.pdb -seq > arsa.model.seq
tr '[:upper:]' '[:lower:]' < arsa.model.seq > arsa.model.lower.seq
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