Difference between revisions of "Hemochromatosis 2011"

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{{About|hemochromatosis associated with the HFE gene|other causes of hemochromatosis|iron overload}}
  
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{{Cleanup|date=January 2008}} <!--tagged for cleanup for source purposes, see talk-->
  
 
{{Infobox Disease |
  
{{Infobox Disease |
 
Name = Hemochromatosis type 1 |
  
Name = Hemochromatosis type 1 |

Revision as of 10:59, 15 May 2011

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Hemochromatosis is a hereditary autosomal recessiv genetic disorder caused by a mutation of the HFE-Gen.

Phenotype

Hemochromatosis causes different symptoms like skin discoloration and liver cirrhosis.

HEF-Gen

Source: http://www.pdb.org/pdb/explore/explore.do?structureId=1A6Z

The HFE-Gen alleviate the binding of transferrin which is the carrier protein for iron in the blood cyclus. With a mutated HFE-Gen, the intestines interpret a strong transferrin signal as an deficient in iron. Therefore the cells start to import iron, which leads to an iron overload.

Mutation

assigned Sequence 1

under construction 'till sequences are assingned

assigned Sequence 2

under construction 'till sequences are assingned

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