Difference between revisions of "Task 8: Sequence-based mutation analysis"

From Bioinformatikpedia
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<figtable id="summary">
  
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! reference || mutation || pyhsicochemical properties || pymol visualisation || secondary structure || substitution matrix || PSSM || MSA || SIFT || Polyphen2 || MutationTaster || SNAP || consensus
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! reference || mutation || colspan="2" | pyhsicochemical properties || pymol visualisation || secondary structure || substitution matrix || PSSM || MSA || SIFT || Polyphen2 || MutationTaster || SNAP || consensus
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| || Val53Met || || || || || || || || || || ||
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| || Val53Met || brached chain,nonpolar, uncharged -> sulfur containing\nnonpolar, neutral || || || || || || || || || ||
 
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| || His63Asp || || || || || || || || || || ||
  
| || His63Asp || || || || || || || || || || ||
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| || Arg330Met || || || || || || || || || || ||
  
| || Arg330Met || || || || || || || || || || ||
 
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|+ style="caption-side: bottom; text-align: left" |<font size=2>'''Table 2:''' Summary of the analysis for all mutations.
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|+ style="caption-side: bottom; text-align: left" |<font size=2>'''Table 2:''' Summary of the results of analysis of all mutations.
 
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Physicochemical properties are given as size, side chain polarity and charge

Revision as of 16:10, 22 August 2013

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Lab journal task 8

Mutation selection

<figtable id="mutations">

mutations
nucleotide change amino acid change
Val53Met
His63Asp
Arg67His
Met97Ile
Asn130Ser
Glu168Gln
Leu183Pro
Thr217Ile
Cys282Tyr
Arg330Met
Table 1: List of the 10 selected mutations from HGMD and dbSNP.

</figtable>


Mutation analysis

<figtable id="summary">

reference mutation pyhsicochemical properties pymol visualisation secondary structure substitution matrix PSSM MSA SIFT Polyphen2 MutationTaster SNAP consensus
Val53Met brached chain,nonpolar, uncharged -> sulfur containing\nnonpolar, neutral
His63Asp
Arg67His
Met97Ile
Asn130Ser
Glu168Gln
Leu183Pro
Thr217Ile
Cys282Tyr
Arg330Met
Table 2: Summary of the results of analysis of all mutations.

</figtable>

Physicochemical properties are given as size, side chain polarity and charge

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