Difference between revisions of "Task 8: Sequence-based mutation analysis"

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! reference || mutation || colspan="2" | pyhsicochemical properties || colspan="2" | strucural properties || colspan="3" | conservation || colspan="4" | prediction programms || consensus
  
! reference || mutation || colspan="2" | pyhsicochemical properties || colspan="2" | strucural properties || colspan="3" | conservation || colspan="4" | prediction programms || consensus
 
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! || || from || to || pymol visualisation || secondary structure || substitution matrix || PSSM || MSA || SIFT || Polyphen2 || MutationTaster || SNAP || consensus
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! || || from || to || pymol visualisation || secondary structure || substitution matrix || PSSM || MSA || SIFT || Polyphen2 || MutationTaster || SNAP ||
 
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| || Val53Met || brached chain, nonpolar, uncharged -> sulfur containing, nonpolar, neutral || || || || || || || || || ||
  
| || Val53Met || brached chain, nonpolar, uncharged -> sulfur containing, nonpolar, neutral || || || || || || || || || ||

Revision as of 16:16, 22 August 2013

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Lab journal task 8

Mutation selection

<figtable id="mutations">

mutations
nucleotide change amino acid change
Val53Met
His63Asp
Arg67His
Met97Ile
Asn130Ser
Glu168Gln
Leu183Pro
Thr217Ile
Cys282Tyr
Arg330Met
Table 1: List of the 10 selected mutations from HGMD and dbSNP.

</figtable>


Mutation analysis

<figtable id="summary">

reference mutation pyhsicochemical properties strucural properties conservation prediction programms consensus
from to pymol visualisation secondary structure substitution matrix PSSM MSA SIFT Polyphen2 MutationTaster SNAP
Val53Met brached chain, nonpolar, uncharged -> sulfur containing, nonpolar, neutral
His63Asp
Arg67His
Met97Ile
Asn130Ser
Glu168Gln
Leu183Pro
Thr217Ile
Cys282Tyr
Arg330Met
Table 2: Summary of the results of analysis of all mutations.

</figtable>

Physicochemical properties are given as special property, side chain polarity and charge.

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