Difference between revisions of "Hemochromatosis 2011"

From Bioinformatikpedia
Line 1: Line 1:
−
{{Infobox Disease |
 +
{{Infobox disease
−
Name = Hemochromatosis type 1 |
 +
| Name = Hemochromatosis
−
Image = |
 +
| Image =
−
Caption = |
 +
| Alt =
−
DiseasesDB = 5490 |
 +
| Caption =
−
ICD10 = {{ICD10|E|83|1|e|70}} |
 +
| DiseasesDB =
−
ICD9 = {{ICD9|275.0}} |
 +
| ICD10 = {{ICD10|Group|Major|minor|LinkGroup|LinkMajor}}
−
ICDO = |
 +
| ICD9 = {{ICD9|xxx}}
−
OMIM = 235200 |
 +
| ICDO =
−
MedlinePlus = |
 +
| OMIM =
  +
| MedlinePlus =
−
eMedicineSubj = med |
  
  +
| eMedicineSubj =
−
eMedicineTopic = 975 |
  
  +
| eMedicineTopic =
−
eMedicine_mult = {{eMedicine2|derm|878}} |
  
−
MeshID = D006432 |
 +
| MeshID =
  +
| GeneReviewsID =
  +
| GeneReviewsName =
 
}}
  
}}
   

Revision as of 11:04, 15 May 2011

{{#ifeq:|yes||

{{#if:|}}{{#if:Hemochromatosis|}}

}}{{#ifeq:|yes|{{#if:|{{{title}}}}}}}{{#if:Classification and external resources|{{#if:

|
|{{#if:Classification and external resources
|{{#if: | }} }} }}{{#if:|{{#if: |
|{{#if:{{{subheader2}}}
|{{#if: | }} }} }}{{#if:{{#if:|[[File:|frameless|{{safesubst:#if:upright=1.06 |upright=1.06{{safesubst:#iferror:{{safesubst:#expr:upright=1.06>0}}||px}} |{{safesubst:#if: |{{{2}}}{{safesubst:#iferror:{{safesubst:#expr:{{{2}}}>0}}||px}} |{{safesubst:#iferror:{{safesubst:#expr:>0}}||px}} }} }}|alt=]]}}|{{#if: |
|{{#if:{{#if:|[[File:|frameless|{{safesubst:#if:upright=1.06
|upright=1.06{{safesubst:#iferror:{{safesubst:#expr:upright=1.06>0}}||px}}
|{{safesubst:#if:
 |{{{2}}}{{safesubst:#iferror:{{safesubst:#expr:{{{2}}}>0}}||px}}
 |{{safesubst:#iferror:{{safesubst:#expr:>0}}||px}}
}}

}}|alt=]]}}{{#if:|
}}

|{{#if: | }} }} }}{{#if:|{{#if: |
|{{#if:{{{image2}}}{{#if:|
{{{caption2}}}}}
|{{#if: | }} }} }}{{#if: |
|{{#if:[[{{#ifeq: Group | H

| {{#ifexpr: Major >= 0 and Major < 60 

 | ICD-10 Chapter VII: Diseases of the eye, adnexa
 | {{#ifexpr: Major >= 60
   | ICD-10 Chapter VIII: Diseases of the ear and mastoid process
   | ICD-10 Chapter H
   }}
 }}

| ICD-10 Chapter Group}}|Group]]Major{{#if:minor|.minor}}

|{{#if:ICD-10 | }} }}{{#if: |
|{{#if:xxx
|{{#if:ICD-9 | }} }}{{#if: |
|{{#if:
|{{#if:ICD-O: | }} }}{{#if: |
|{{#if:{{#if:|[1]  }}
|{{#if:OMIM | }} }}{{#if: |
|{{#if:{{#if:|[3]  }}
|{{#if:DiseasesDB | }} }}{{#if: |
|{{#if:{{#if:|[5]   }}
|{{#if:MedlinePlus | }} }}{{#if: |
|{{#if:{{#if:|{{#ifeq:|search|topic list|{{#ifeq:|article|[http://www.emedicine.com//topic.htm}} /}} }}
|{{#if:eMedicine | }} }}{{#if: |
|{{#if:{{#if:|[7]}}
|{{#if:MeSH | }} }}{{#if: |
|{{#if:{{#if:|{{{MeshNumber}}}}}
|{{#if:MeSH | }} }}{{#if: |
|{{#if:{{#if:  | {{#if:{{#if:  | http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part= }}
|[{{#if:  | http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part= }} ]
|

}} }}

|{{#if:GeneReviews | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if: |
|{{#if:
|{{#if: | }} }}{{#if:|}}{{#if:|}} {{#ifeq:|yes||
{{{title}}}
Hemochromatosis
{{{header}}}
{{{label}}} | 
 }}
Classification and external resources
{{{header}}}
{{{label}}} | 
 }}
{{{subheader2}}}
{{{header}}}
{{{label}}} | 
 }}

{{#if:|[[File:|frameless|{{safesubst:#if:upright=1.06 

|upright=1.06{{safesubst:#iferror:{{safesubst:#expr:upright=1.06>0}}||px}}
|{{safesubst:#if:
 |{{{2}}}{{safesubst:#iferror:{{safesubst:#expr:{{{2}}}>0}}||px}}
 |{{safesubst:#iferror:{{safesubst:#expr:>0}}||px}}
}}
}}|alt=]]}}{{#if:|
}}
{{{header}}}
{{{label}}} | 
 }}
{{{image2}}}{{#if:|
{{{caption2}}}}}
ICD-10 | 
 }}

[[{{#ifeq: Group | H | {{#ifexpr: Major >= 0 and Major < 60 

 | ICD-10 Chapter VII: Diseases of the eye, adnexa
 | {{#ifexpr: Major >= 60
   | ICD-10 Chapter VIII: Diseases of the ear and mastoid process
   | ICD-10 Chapter H
   }}
 }}
| ICD-10 Chapter Group}}|Group]]Major{{#if:minor|.minor}}
ICD-9 | 
 }}
xxx
ICD-O: | 
 }}
OMIM | 
 }}
{{#if:|[2] }}
DiseasesDB | 
 }}
{{#if:|[4] }}
MedlinePlus | 
 }}
{{#if:|[6] }}
eMedicine | 
 }}
{{#if:|{{#ifeq:|search|topic list|{{#ifeq:|article|[http://www.emedicine.com//topic.htm}} /}} }}
MeSH | 
 }}
{{#if:|[8]}}
MeSH | 
 }}
{{#if:|{{{MeshNumber}}}}}
GeneReviews | 
 }}

{{#if: | {{#if:{{#if: | http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part= }} 

|[{{#if:  | http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part= }} ]
|
}} }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
| 
 }}
{{{below}}}
{{#if:1||This box: }}{{#if:|[}}
  • [[{{#switch: 
    |#default =  
| = 
   {{#ifeq:  | 
     | Template:{{{name}}}            
     |       
   }}
    }}|{{#if:1|v|view}}]]
  • [[|{{#if:1|t|talk}}]]
    • {{#if:||
  • [{{fullurl:{{#switch: 
    |#default =  
| = 
   {{#ifeq:  | 
     | Template:{{{name}}}            
     |       
   }}
    }}|action=edit}} {{#if:1|e|edit}}]
    • }}
{{#if:|]}}

}}{{#switch:¬ 

|¬|no       = 
||force|yes =

}}{{#ifeq:|yes||{{#if:[[{{#ifeq: Group | H | {{#ifexpr: Major >= 0 and Major < 60 

 | ICD-10 Chapter VII: Diseases of the eye, adnexa
 | {{#ifexpr: Major >= 60
   | ICD-10 Chapter VIII: Diseases of the ear and mastoid process
   | ICD-10 Chapter H
   }}
 }}

| ICD-10 Chapter Group}}|Group]]Major{{#if:minor|.minor}}xxx{{#if:|[9] }}{{#if:|[10] }}{{#if:|[11] }}{{#if:|{{#ifeq:|search|topic list|{{#ifeq:|article|[http://www.emedicine.com//topic.htm}} /}} }}{{#if:|[12]}}{{#if:|{{{MeshNumber}}}}}{{#if: | {{#if:{{#if: | http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part= }} 

|[{{#if:  | http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part= }} ]
|

}} }}||{{#switch: 

 {{#if: 
   | {{{demospace}}}
   | {{#if: 
     | 
       {{#ifeq:|
       | talk
       |  
       }}
     | 
       {{#ifeq:|talk
       | talk
       |  
       }}
     }}
   }}

| main | = | talk = | user = | wikipedia = | file | image = | mediawiki = | template = | help = | category = | portal = | book = | other | #default =

}}}}}}


Hemochromatosis is a hereditary autosomal recessiv genetic disorder caused by a mutation of the HFE-Gen.

Phenotype

Hemochromatosis causes different symptoms like skin discoloration and liver cirrhosis.

HEF-Gen

Source: http://www.pdb.org/pdb/explore/explore.do?structureId=1A6Z

The HFE-Gen alleviate the binding of transferrin which is the carrier protein for iron in the blood cyclus. With a mutated HFE-Gen, the intestines interpret a strong transferrin signal as an deficient in iron. Therefore the cells start to import iron, which leads to an iron overload.

Mutation

assigned Sequence 1

under construction 'till sequences are assingned

assigned Sequence 2

under construction 'till sequences are assingned

Retrieved from "https://i12r-studfilesrv.informatik.tu-muenchen.de/wiki/index.php?title=Hemochromatosis_2011&oldid=407"