Difference between revisions of "Task 9 (MSUD)"

From Bioinformatikpedia
m (Results)
m (Results)
Line 12: Line 12:
 
<tr><td>HGMD</td><td>CM062448</td><td>R346H</td><td>True</td></tr>
 
<tr><td>HGMD</td><td>CM062448</td><td>R346H</td><td>True</td></tr>
 
<tr><td>dbSNP</td><td>rs61736656</td><td>I361V </td><td>False</td></tr>
 
<tr><td>dbSNP</td><td>rs61736656</td><td>I361V </td><td>False</td></tr>
<tr><td></td></tr>
 
 
</table>
 
</table>
   

Revision as of 11:20, 12 July 2013

Results

Lab journal

For this task we have chosen 5 mutations from HGMD and dbSNP. 2 of them are neutral mutations which do not have functional changes over the protein structure. Following are the 5 mutations:

DatabaseAccession_codeMutationPathogenic
dbSNPrs11549938M82LFalse
dbSNPrs141086188A222TFalse
HGMDCM045934C264WTrue
HGMDCM062448R346HTrue
dbSNPrs61736656I361V False

Visualization of mutant structures

The mutagen tool of PyMOL was used to introduce mutations to the protein structure. Mutations and their neighboring residues are visualized and shown in following figures.

Mutant structures (SCWRL)

Energy comparisons

FoldX

Minimise

Gromacs