Difference between revisions of "Talk:Fabry:Structure-based mutation analysis"
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In general we find you often are too prompt with your conclusion, that a mutation "has to be disease causing". This always sounds so absolute, but even when it seems that a mutation really changes something in the structure, this must not necessarily mean it is disease causing. So maybe formulate the conclusio less "hard" and say you "think, this mutation is disease causing". I hope this does not sound too picky, but when reading the article it makes a difference.. I think . ;) |
In general we find you often are too prompt with your conclusion, that a mutation "has to be disease causing". This always sounds so absolute, but even when it seems that a mutation really changes something in the structure, this must not necessarily mean it is disease causing. So maybe formulate the conclusio less "hard" and say you "think, this mutation is disease causing". I hope this does not sound too picky, but when reading the article it makes a difference.. I think . ;) |
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| + | In the minimise part concerning figure 2: |
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| + | Did you also look at the precise positioning of the amino acids? Because Pymol just uses some kind of angle and bond defininition in order to declare a part as helix or sheet. I mean it is just a question of definition, when pymol shows you beta sheets or not. |
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Latest revision as of 07:38, 26 June 2012
Hellohello! Finally some statements that you probably dont get to see before we meet :/
Nice and structured entry with not too many pics. :D Or at least they are small and not overwhelming!
In table 3 you have have to get rid of: "Clashes are depicted as red and green disks" That was for table 2 I guess ;)
In general we find you often are too prompt with your conclusion, that a mutation "has to be disease causing". This always sounds so absolute, but even when it seems that a mutation really changes something in the structure, this must not necessarily mean it is disease causing. So maybe formulate the conclusio less "hard" and say you "think, this mutation is disease causing". I hope this does not sound too picky, but when reading the article it makes a difference.. I think . ;)
In the minimise part concerning figure 2:
Did you also look at the precise positioning of the amino acids? Because Pymol just uses some kind of angle and bond defininition in order to declare a part as helix or sheet. I mean it is just a question of definition, when pymol shows you beta sheets or not.
