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= PSI-BLAST - PSSM = Command: blastpgp -i ref_seq_BCKDHA.fas -d /mnt/project/rost_db/data/big/big -j 5 -Q BCKDHA.pssm -o blast.out Last position-specific scoring matrix computed, weighted observed percentages rounded down, information per position, and relative weight of gapless real matches to pseudocounts A R N D C Q E G H I L K M F P S T W Y V A R N D C Q E G H I L K M F P S T W Y V 1 M -2 -3 -4 -5 -3 -2 -4 -4 -3 0 3 -3 8 -1 -4 -3 -2 -3 -2 1 0 0 0 0 0 0 0 0 0 0 27 0 63 0 0 0 0 0 0 10 1.00 inf 2 A 3 -2 -1 -2 -2 -2 -2 1 -2 -3 -2 -2 -2 -3 2 3 1 -4 -3 -2 39 0 2 0 0 0 0 8 0 0 2 0 0 0 8 31 10 0 0 0 0.46 inf 3 V 1 1 -2 -3 -2 -2 -2 -2 -2 1 1 -1 0 1 1 1 -1 -3 -1 1 17 13 0 0 0 0 0 0 0 10 19 0 0 9 7 13 2 0 0 11 0.13 inf 4 A 1 -1 -2 -3 -2 -1 -2 -2 -3 0 2 -2 0 -1 2 2 0 -3 -2 0 17 3 0 0 0 2 0 0 0 1 31 0 0 1 12 24 4 0 0 5 0.25 inf 5 I -1 3 -2 -3 -3 -1 -2 -2 -2 2 2 -1 0 2 -3 -1 -1 -3 -1 0 5 30 0 0 0 1 0 3 0 17 24 1 1 10 0 6 1 0 0 1 0.24 inf 6 A 0 2 0 -2 -1 0 0 -1 0 0 0 1 -1 -2 -1 2 1 -3 -1 -1 9 19 2 0 1 1 3 4 3 6 10 8 0 0 1 25 7 0 1 0 0.15 inf 7 A 2 1 -2 -2 1 0 0 0 -2 -1 -1 -1 0 -3 1 1 1 -3 -3 -1 31 11 0 0 3 3 8 6 0 2 6 0 4 0 7 11 9 0 0 1 0.19 inf 8 A 0 1 0 -2 1 -2 -2 -1 -2 0 -2 -1 -2 -3 5 1 1 -4 -3 0 10 11 4 0 3 0 0 5 0 8 1 2 0 0 30 10 8 0 0 9 0.41 inf 9 R 2 4 -1 -3 2 0 -2 -2 -2 0 0 1 -1 -3 0 -1 -1 -3 -2 0 23 32 2 0 6 2 0 0 0 5 10 5 0 0 4 1 3 0 0 5 0.27 inf 10 V -2 -1 -3 -4 2 -3 -3 -1 -3 2 2 -3 2 2 -2 -2 -2 0 -1 2 0 3 0 0 6 0 0 5 0 13 27 0 6 12 2 3 0 1 0 23 0.27 inf 11 W 1 2 -2 -2 0 -1 -2 0 1 0 0 -1 -1 -2 -2 1 0 4 0 -1 18 15 0 1 2 1 0 5 4 7 14 0 0 0 1 16 5 8 2 1 0.15 inf 12 R 0 4 0 -2 -3 1 1 1 2 -2 -1 0 -2 -3 1 -1 -1 -4 -2 -2 8 31 4 0 0 4 8 13 7 3 7 3 0 0 6 2 2 0 0 1 0.25 inf 13 L 0 0 -2 -2 -2 -1 -2 -2 1 0 1 -1 1 -2 2 2 0 2 -1 0 6 6 0 0 0 2 0 2 6 7 18 2 5 0 10 22 3 3 1 8 0.13 inf 14 N 1 1 1 0 -1 0 -1 0 -2 -2 0 0 -1 -3 2 2 1 -3 -2 -1 9 9 9 4 1 3 0 4 0 0 10 5 0 0 11 20 10 0 1 4 0.17 inf 15 R 0 5 0 -2 -1 1 -1 -1 -1 -1 -1 0 -2 -3 -2 1 0 -4 -3 -1 8 43 3 0 1 7 0 3 1 5 4 2 0 0 1 12 4 0 0 3 0.40 inf 16 G 0 0 -1 -2 -3 -1 -2 3 3 -2 -2 0 -2 -2 3 1 -1 -4 -2 -1 7 4 2 0 0 2 0 28 9 1 3 5 1 2 16 14 2 0 0 5 0.33 inf 17 L 1 1 -2 -2 -2 -1 -1 -2 0 0 2 -2 1 1 0 -1 -1 0 0 1 13 9 0 2 0 2 3 2 3 3 31 0 2 9 4 2 1 1 1 12 0.10 inf 18 S 0 3 -1 -2 -2 2 -1 -1 2 -2 -1 0 -1 -2 1 2 1 -3 -1 -1 8 19 1 0 1 12 0 4 8 0 6 2 1 1 8 17 8 0 1 3 0.21 inf 19 Q 0 3 0 -2 -3 2 -1 -2 -1 -2 -1 1 -2 2 0 1 0 -3 -1 -2 11 18 5 0 0 14 0 1 1 1 5 9 0 15 5 9 5 0 0 2 0.20 inf 20 A 2 -1 -1 -2 -2 -1 -2 -1 -2 0 1 -1 1 -2 0 1 0 -3 -1 1 28 4 3 0 0 2 0 1 1 5 14 2 5 0 5 16 2 0 2 9 0.14 inf 21 A 1 2 -1 -2 1 0 -1 0 -1 -1 -1 0 -1 -2 2 2 0 -3 -2 -1 14 15 0 0 4 4 2 5 1 4 6 2 1 1 11 22 5 0 1 2 0.19 inf 22 L 0 1 -1 -2 2 -1 -2 -1 1 -1 1 0 0 0 3 0 -1 -3 -2 -1 11 8 3 0 7 1 0 4 6 3 17 5 1 5 17 8 2 0 0 3 0.16 inf 23 L 1 1 1 -1 1 1 -1 -1 1 0 0 0 -1 -2 2 0 0 -3 -2 0 13 11 9 2 3 7 0 3 4 4 11 2 1 1 11 6 3 0 0 10 0.10 inf 24 L 0 0 -1 -1 -1 -1 -1 -2 1 0 2 0 0 0 -2 0 1 -2 0 0 10 7 1 4 1 2 2 2 4 4 28 5 0 2 0 10 9 0 3 5 0.06 inf 25 L 0 0 -1 -2 -1 -1 -1 -1 -1 0 2 -1 2 0 2 -1 0 0 -1 0 9 7 2 0 1 3 2 5 1 4 25 3 7 5 11 4 3 1 0 6 0.09 inf 26 R 0 4 0 -2 -3 0 -1 -1 1 -1 -2 1 -2 -3 -1 2 1 -4 -2 -2 9 33 4 0 0 2 1 2 3 5 1 5 0 0 2 23 8 0 1 0 0.36 inf 27 Q -1 2 0 1 -3 0 0 -1 0 -1 -1 0 -1 -2 1 1 1 0 -2 0 2 20 3 7 0 5 2 5 2 3 6 4 0 2 6 10 14 1 0 8 0.12 inf 28 P 1 0 0 -1 -1 -1 -1 0 -2 -1 -1 0 -1 -1 3 2 1 -3 -2 0 15 6 4 3 1 1 1 7 0 1 7 4 2 2 15 18 8 0 0 6 0.18 inf 29 G 2 1 -1 -2 0 -1 -1 2 -1 -1 -1 -1 0 -1 -2 1 0 -3 -2 0 24 10 2 1 2 2 1 16 1 5 4 2 4 3 1 14 6 0 0 5 0.14 inf 30 A 1 0 2 -1 -2 1 0 1 0 -1 -1 0 0 -3 0 1 1 -3 -2 0 15 3 13 1 0 8 3 10 2 4 4 4 2 0 3 14 7 0 0 7 0.12 inf 31 R 0 3 0 -2 2 0 -1 -1 1 -1 0 0 0 0 0 1 0 0 1 -1 6 22 3 1 5 3 1 3 3 1 15 4 1 3 5 11 3 1 5 2 0.11 inf 32 G -1 0 1 -2 -1 -1 -2 2 -1 -2 -1 -1 -2 -3 4 1 1 1 -2 -1 2 8 6 0 1 1 1 20 1 1 6 2 0 0 20 13 9 3 1 5 0.30 inf 33 L 1 -1 -1 -2 -2 0 1 -2 -2 -1 1 -1 -1 -1 3 1 1 -3 -2 -1 12 3 1 0 0 3 9 1 1 3 19 3 1 2 19 10 12 0 1 2 0.23 inf 34 A 1 -2 -2 -3 -1 -2 -2 -2 -1 -1 2 -2 0 0 3 1 0 -1 -2 -1 18 0 1 0 1 1 2 1 2 2 34 1 1 3 14 11 6 1 0 1 0.26 inf 35 R 0 5 -1 -2 -3 0 0 -2 -1 -3 -2 1 -2 -3 -3 1 -1 0 -2 -2 7 47 2 0 0 3 3 2 1 1 4 7 0 1 1 15 2 1 1 2 0.54 inf 36 S 0 -1 -2 -1 0 -1 -1 -2 -1 -1 2 -1 0 0 3 2 0 -3 -2 -1 5 4 1 3 2 1 2 2 2 2 28 2 1 3 15 20 7 0 0 2 0.21 inf 37 H 0 -1 0 0 -1 -1 0 -2 7 -2 -2 -2 -2 -1 -2 -1 0 1 1 0 7 3 3 5 1 2 6 1 38 1 3 1 0 2 1 4 7 2 5 7 0.51 inf 38 P 1 0 -1 -2 -1 -1 -1 -1 -1 0 -1 -1 -1 -1 3 0 -1 -4 -2 3 11 7 2 1 1 1 2 3 1 4 2 3 0 3 18 9 2 0 0 30 0.25 inf 39 P -2 3 -1 -1 -2 -1 -1 -2 -2 -2 -1 -1 -2 -4 5 1 0 1 -3 -1 1 20 2 2 1 0 4 2 0 2 5 2 0 0 35 11 6 2 0 4 0.61 inf 40 R 0 3 -1 -1 -3 2 4 -1 0 -3 -2 0 -1 -1 -1 0 0 -3 -2 -1 6 18 2 0 0 11 31 3 2 0 2 1 1 4 2 8 4 0 0 4 0.33 inf 41 Q 0 -1 -2 -1 -3 2 -1 -2 -3 -2 -2 -1 -3 -4 6 1 -1 -4 -3 -2 6 3 0 3 0 14 2 1 0 2 3 1 0 0 43 15 3 0 0 3 0.82 inf 42 Q 0 0 -1 -2 -1 4 0 -2 -1 -1 -2 0 1 0 1 2 0 -3 -2 -1 7 2 1 1 1 28 4 2 1 3 2 5 5 4 6 18 6 0 0 5 0.25 inf 43 Q 0 1 -1 -1 -1 3 2 1 -1 -2 -2 0 -2 0 -1 1 0 0 -1 -1 8 10 2 1 1 18 14 10 1 2 2 4 0 6 1 9 4 1 2 5 0.15 inf 44 Q -1 5 0 -1 -4 2 2 -2 0 -3 -2 1 -2 -3 2 0 -2 -4 -3 -3 5 38 3 2 0 11 13 2 2 1 3 4 0 1 9 6 1 0 0 0 0.51 inf 45 F 0 -3 -1 -2 -3 -1 -2 -3 1 -1 -1 -2 -2 4 5 -2 -2 -1 1 -1 8 0 3 1 0 2 2 1 4 2 6 1 0 21 37 1 1 1 5 5 0.68 inf 46 S 0 0 -1 -1 -1 -1 -2 4 0 -3 -4 -1 -3 -3 1 3 0 0 -3 -2 3 5 1 3 1 1 1 38 2 1 0 2 0 0 7 25 5 1 0 2 0.48 inf 47 S -1 -1 1 3 2 1 0 0 0 -3 -3 -1 -3 -4 1 3 0 -4 -2 -3 2 2 5 16 5 6 6 6 3 2 1 1 0 0 6 36 2 0 1 1 0.35 inf 48 L 1 0 -1 -1 -2 0 -1 0 0 0 1 0 0 -1 -1 0 1 -2 -1 0 14 6 1 3 0 5 2 6 2 2 24 7 0 2 2 3 12 0 2 7 0.05 inf 49 D -1 -2 -1 3 -3 0 2 -2 -1 -2 -3 -1 -2 -2 3 1 1 -3 -3 -1 4 1 1 21 0 3 17 2 1 1 2 1 0 2 18 13 8 0 0 5 0.40 inf 50 D 0 0 0 5 -4 1 3 -1 -2 -3 -3 -1 -3 -4 -2 1 -1 -4 -2 -3 9 4 1 39 0 6 19 4 0 0 2 2 0 0 0 8 1 0 1 1 0.56 inf 51 K -1 1 -2 -3 -3 0 0 -1 0 -1 -1 3 -1 4 -1 -1 -2 -2 0 0 3 7 0 0 0 3 4 4 2 1 5 25 1 28 2 4 1 0 2 9 0.27 inf 52 P 0 -2 -1 0 0 0 -1 -2 -1 -1 -2 -2 -1 -3 5 2 -1 0 -2 1 5 0 2 4 2 5 2 1 1 2 2 1 1 0 29 24 2 2 1 14 0.46 inf 53 Q -1 1 2 1 -3 4 0 -1 3 -4 -3 0 -2 -1 0 -1 -2 -2 3 -3 3 7 14 10 0 23 2 3 9 0 2 2 1 2 4 3 0 0 14 0 0.38 inf 54 F -3 -4 -5 -5 -4 -4 -3 -3 -4 0 2 -4 -1 7 -5 -4 -3 -2 1 1 1 1 0 0 0 0 1 2 0 3 18 0 0 59 0 0 0 0 1 12 1.08 inf 55 P -2 -1 -2 0 -5 -1 -1 -1 2 -4 -3 -1 -2 -4 7 -1 -2 -5 -4 -3 1 3 1 5 0 3 2 6 6 0 3 4 1 0 59 4 1 0 0 1 1.24 inf 56 G -1 -3 -1 -2 -4 -3 -3 5 -2 1 0 -1 -2 -2 -4 -1 -2 -4 -3 -1 2 0 2 1 0 0 1 56 1 11 11 5 1 2 0 4 0 0 0 3 0.66 inf 57 A 3 -1 -2 -2 -2 -2 -2 1 1 -1 -1 -1 -1 -3 3 1 -1 -4 -1 -1 38 3 1 2 0 1 1 9 5 5 6 1 1 0 14 10 2 0 1 1 0.31 inf 58 S -1 2 2 0 -3 1 0 -2 -1 -4 -3 3 -2 -4 2 2 -1 -4 -3 -3 3 11 14 5 0 6 5 2 1 0 1 23 1 0 9 18 2 0 0 0 0.38 inf 59 A 4 -2 -1 -2 -1 -2 -2 -2 -2 0 -2 -2 0 -3 -1 2 1 -4 -3 1 47 1 2 1 1 0 0 0 0 4 2 0 2 1 2 19 7 0 0 11 0.45 inf 60 E 0 0 -1 -1 -4 2 3 2 -2 -3 -3 1 -2 -4 2 0 -1 -2 -3 -3 5 5 0 1 0 9 26 20 0 1 1 11 0 0 12 4 2 0 0 1 0.41 inf 61 F 1 -3 -3 -3 -3 -2 -1 -4 -3 -1 -1 -3 -2 6 -2 -1 0 3 2 -1 12 0 1 1 0 1 4 0 0 2 2 1 0 49 2 5 7 3 6 4 0.67 inf 62 I -1 -3 -2 -2 -2 0 -3 -3 -3 2 -1 -2 -1 -2 -3 0 4 -4 -3 4 4 0 1 1 0 4 0 0 0 10 1 1 0 1 0 5 36 0 0 34 0.53 inf 63 D -1 1 2 3 -3 0 1 -1 2 -3 -3 -1 -3 -3 2 1 1 -4 -1 -3 4 10 11 22 0 2 6 3 7 0 1 1 0 1 10 11 9 0 1 0 0.34 inf 64 K -1 3 0 1 -2 2 2 -2 -1 -3 -3 4 -3 -4 -1 0 1 -4 -3 -3 3 16 4 7 1 7 14 1 1 0 0 30 0 0 1 6 8 0 0 0 0.44 inf 65 L -2 -4 -4 -5 -3 -3 -4 -5 -4 0 4 -3 5 -2 4 -3 -2 -4 -3 1 3 0 0 0 0 0 0 0 0 3 41 0 20 1 22 0 0 0 0 8 0.82 inf 66 E -1 0 0 2 -4 1 3 -2 0 -3 -3 2 -3 -4 1 1 0 -4 -2 -3 4 4 3 15 0 5 27 1 2 1 1 12 0 0 7 11 5 0 1 1 0.38 inf 67 F -3 -4 -4 -5 -4 -3 -3 -3 -2 1 0 -3 0 7 -2 -3 1 2 0 1 1 0 0 0 0 1 1 1 0 8 6 1 2 54 3 1 9 3 0 9 0.83 inf 68 I 0 -1 -2 -1 -2 -1 1 -3 -2 4 1 -2 0 0 -3 -1 0 -3 -2 2 7 3 1 2 0 2 10 1 1 33 13 1 1 3 0 3 5 0 0 13 0.21 inf 69 Q 1 0 2 2 -3 4 1 -2 1 -3 -1 0 -1 -3 0 0 0 -4 -3 -2 14 3 14 11 0 23 5 1 3 0 5 3 2 0 4 5 6 0 0 1 0.29 inf 70 P -1 1 -2 0 -2 0 3 0 -1 -4 -4 0 -4 -5 6 -1 -2 -5 -4 -4 3 7 1 5 1 3 21 6 2 0 0 4 0 0 43 4 1 0 0 0 0.91 inf 71 N 1 -1 3 2 -2 0 2 -1 -1 -3 -3 0 -1 -3 -2 1 1 -2 -2 -1 13 3 19 12 0 1 14 2 1 1 2 3 1 0 1 12 10 0 1 3 0.27 inf 72 V 1 -2 -1 2 -2 0 1 -1 -2 0 -1 -1 -1 -2 2 1 0 -3 -2 2 10 0 2 13 0 4 9 2 1 4 3 2 1 1 11 10 6 0 1 21 0.16 inf 73 I -1 0 -2 0 -2 0 1 -3 -1 2 0 -1 1 1 -3 -1 0 -2 2 0 4 4 1 6 0 5 13 1 1 20 7 3 6 5 0 3 5 0 12 5 0.11 inf 74 S 0 1 0 2 -2 0 2 -2 0 -3 -2 0 -2 -4 2 2 1 -4 -3 -3 6 9 4 12 1 2 15 1 2 0 3 5 1 0 9 22 7 0 0 0 0.29 inf 75 G 1 1 -1 1 -3 1 0 3 -2 -3 -2 0 -2 -3 2 0 0 -3 -2 -2 18 8 1 8 0 9 4 24 0 1 3 4 0 0 9 3 5 0 1 1 0.25 inf 76 I -2 -4 -3 -4 -3 -4 -3 -5 -3 5 2 -3 2 4 -4 -3 -1 -1 0 1 1 0 2 1 0 0 2 0 0 45 16 1 4 18 0 0 2 1 2 4 0.62 inf 77 P -2 -3 -3 -2 -5 -1 0 -1 -3 -4 -5 -2 -4 -5 8 0 -2 -5 -5 -4 1 1 1 1 0 2 8 5 1 1 0 1 0 0 69 8 1 0 0 0 1.70 inf 78 I -2 -3 -3 -4 3 -3 -3 -4 -4 4 2 -3 3 -1 -3 -2 3 -4 -3 2 0 0 0 0 8 1 0 0 0 28 16 1 11 1 1 0 22 0 0 11 0.51 inf 79 Y -3 -3 -5 -5 -4 -4 -4 -5 -1 2 0 -4 -1 4 -5 -4 -3 0 7 2 0 1 0 0 0 0 0 0 0 11 7 1 0 17 0 0 0 0 45 17 1.08 inf 80 R -3 7 -2 -4 -6 4 -2 -4 1 -6 -5 1 -4 -5 -4 -2 -2 -5 -4 -5 1 69 0 0 0 20 0 0 3 0 0 3 0 0 0 2 1 0 0 0 1.53 inf 81 V -2 -4 -5 -5 -2 -4 -5 -5 -5 4 0 -4 -1 -2 -5 -4 -1 -5 -2 6 1 1 0 0 1 0 0 0 0 21 7 0 0 0 0 0 3 0 1 66 1.09 inf 82 M -3 -4 -5 -6 -2 -4 -5 -6 -5 1 5 -4 6 -2 -5 -4 -2 -4 -3 0 0 0 0 0 1 0 0 0 0 6 61 0 28 0 0 0 1 0 0 3 1.22 inf 83 D -3 -2 4 7 -5 0 -1 -1 -3 -5 -6 -1 -5 -6 -4 0 -2 -6 -5 -5 2 1 19 64 0 3 1 3 0 0 0 3 0 0 0 5 1 0 0 0 1.34 inf 84 R 0 3 0 2 -4 1 3 -2 0 -3 -2 1 -2 -3 0 0 -1 -4 -2 -3 6 17 2 14 0 6 24 2 1 0 4 6 1 1 5 7 3 0 1 0 0.33 inf 85 Q -1 -2 2 5 -3 3 3 -2 1 -4 -4 0 -3 -4 -3 -1 -1 -4 -2 -3 4 1 10 35 0 15 19 1 3 1 1 3 0 0 0 2 2 0 1 1 0.65 inf 86 G -2 -4 -2 -3 -5 -4 -4 7 -2 -6 -6 -4 -5 -5 -4 -2 -4 -5 -5 -5 1 0 1 1 0 0 0 92 1 0 0 0 0 0 0 2 0 0 0 0 1.94 inf 87 Q -1 1 2 0 -2 3 2 -2 0 -2 -3 1 -1 -3 -2 0 1 -4 -2 -1 3 9 13 4 1 19 15 0 2 1 1 8 1 0 0 6 10 0 1 5 0.31 inf 88 I 2 -3 -4 -3 -2 -3 -3 -3 -3 4 2 -3 0 -1 -1 -2 -1 0 -2 3 19 0 0 1 0 1 1 1 0 29 20 1 1 1 2 0 2 1 0 19 0.39 inf 89 I -1 -2 -2 -3 -2 -2 -2 -4 1 3 1 -3 -1 -1 -3 -2 -1 -3 0 4 2 1 1 1 0 2 1 0 4 21 12 1 0 1 0 2 2 0 4 44 0.47 inf 90 N -1 -2 4 3 -2 -1 1 3 -2 -4 -4 0 -3 -4 0 0 -1 -4 -3 -3 3 1 26 21 1 1 9 21 0 1 1 4 0 0 5 5 1 0 0 1 0.52 inf 91 P -2 -2 0 2 -3 -1 2 2 -3 -4 -4 1 -3 -4 5 -1 -2 -4 -4 -4 2 0 4 11 0 2 16 14 0 0 1 8 0 0 36 4 2 0 0 0 0.74 inf 92 S 2 -2 -1 0 -3 0 2 -1 0 -3 -3 -1 -2 -2 -1 2 0 7 -2 -2 17 1 2 6 0 2 14 3 2 1 2 3 0 1 3 22 3 16 0 1 0.43 inf 93 E 1 0 0 0 -1 2 3 -1 1 -2 -1 0 -1 -1 0 0 0 -2 0 -1 15 4 2 4 2 9 22 2 3 1 4 5 1 3 3 5 6 0 4 5 0.14 inf 94 D 0 -1 0 4 -2 -1 1 0 -1 -1 0 -1 2 -1 -2 -1 -1 -3 -2 0 7 1 4 31 1 1 7 6 2 2 7 4 8 3 0 2 2 0 1 11 0.21 inf 95 P -1 -3 -3 -2 -4 -2 0 -3 -2 -2 -2 -2 -3 -4 7 -1 -2 -4 -3 -2 3 1 0 2 0 2 5 1 1 2 4 1 0 0 69 3 1 0 1 3 1.59 inf 96 H -1 0 1 3 -2 3 2 -1 2 -3 -3 1 -2 -2 0 -1 0 -3 -2 -2 4 2 7 23 1 15 11 3 6 1 1 11 0 2 3 2 4 0 0 3 0.32 inf 97 L -2 -3 -4 -4 -3 -3 -3 -4 -4 3 4 -4 2 1 -4 -3 -2 -3 -1 1 1 0 0 0 0 0 1 1 0 18 55 0 3 7 0 0 1 0 1 9 0.65 inf 98 P -1 -3 0 3 -3 -2 0 -1 -2 -4 -4 -1 -3 -4 4 3 2 -4 -4 -3 3 0 2 20 0 0 5 3 0 0 1 2 0 0 21 30 12 0 0 0 0.61 inf 99 K -1 2 0 4 -4 1 2 -2 -2 -3 -3 3 -3 -4 2 -1 -2 -4 -3 -2 3 14 3 25 0 7 12 1 0 0 1 19 0 0 10 1 1 0 0 3 0.46 inf 100 E 0 -2 -1 3 -5 1 6 -2 -1 -4 -4 -1 -4 -5 -3 -1 -2 -5 -4 -3 8 0 2 19 0 3 59 2 1 0 0 2 0 0 1 1 1 0 0 1 0.97 inf 101 K -1 0 -1 -1 -3 3 2 -3 0 -1 1 1 0 -1 -2 -1 1 -1 -2 0 4 3 1 1 0 19 19 1 2 2 14 7 2 3 0 2 14 1 1 6 0.20 inf 102 V 2 -3 -4 -4 0 -3 -3 -3 -4 1 3 -3 1 -1 -3 -2 -1 -3 -2 3 20 0 0 0 2 0 0 1 0 4 43 0 2 1 0 0 2 0 1 23 0.47 inf 103 L -2 2 -2 -3 -3 -1 -1 -3 -2 2 3 0 1 -2 -3 -2 -1 -3 -2 2 0 12 1 0 0 3 2 1 1 10 37 8 2 0 0 0 2 0 0 19 0.31 inf 104 K 0 3 0 0 -4 1 2 -2 -1 -4 -3 4 -3 -4 -2 -1 0 -2 -3 -3 8 13 3 4 0 5 18 1 1 0 1 37 0 0 0 2 4 0 0 1 0.51 inf 105 L -1 -3 -4 -4 -3 -3 -4 1 -2 2 2 -3 6 2 -4 -2 -2 2 -1 0 3 0 0 0 0 0 0 15 1 11 19 0 32 10 0 1 0 3 1 2 0.56 inf 106 Y -4 -4 -4 -5 -4 -3 -4 -4 1 -2 1 -4 4 1 -5 -4 -4 -1 8 -3 0 0 0 0 0 1 0 1 2 0 14 0 11 3 0 0 0 0 65 0 1.50 inf 107 K -2 6 -1 0 -4 1 1 -3 0 -4 -3 3 -3 -4 -3 -1 -1 -4 -3 -4 1 47 1 5 0 5 8 1 2 0 2 19 0 0 0 4 3 0 0 0 0.74 inf 108 S 1 1 1 2 -2 1 0 -2 2 -2 -2 1 -2 -2 -2 1 1 1 -1 -2 12 8 9 12 1 5 3 1 8 2 3 7 0 1 0 13 12 2 2 1 0.17 inf 109 M -4 -4 -5 -6 -1 -3 -5 -5 -4 -1 0 -4 10 -2 -5 -4 -3 -4 -4 -2 0 0 0 0 2 0 0 0 0 1 4 0 90 1 0 0 0 0 0 0 2.44 inf 110 T -1 -1 -3 -3 -1 -1 -2 -3 -3 2 2 -1 2 -2 -3 -2 2 -2 -2 3 4 4 1 0 1 2 1 0 0 9 23 3 6 0 0 1 15 0 0 29 0.29 inf 111 L -1 2 -2 -3 -1 1 -1 -3 -2 -1 3 1 0 1 -3 -1 1 2 1 -1 3 12 0 0 1 6 2 1 0 0 35 8 1 7 0 2 13 3 6 1 0.21 inf 112 L 0 -3 -2 -3 -2 -2 -3 -2 -2 1 3 -3 2 -1 -3 -1 3 -3 -2 1 9 0 1 0 0 1 0 2 1 7 35 0 5 2 0 2 23 0 0 10 0.32 inf 113 N -3 6 4 -2 -4 1 -1 -3 -1 -5 -4 0 -3 -4 -1 1 -2 -5 -3 -4 0 49 25 0 0 5 2 0 1 0 0 1 0 0 4 11 0 0 0 0 0.91 inf 114 T 1 -2 -2 -3 -2 -1 -1 -3 1 3 0 -2 0 -2 -3 0 3 -3 -2 2 13 1 0 0 0 2 2 0 5 24 5 1 2 0 0 6 25 0 1 13 0.28 inf 115 M -2 -3 -3 -5 -3 -3 -4 -4 -3 0 2 -4 7 4 -4 -3 -3 3 1 1 2 0 1 0 0 0 0 0 0 3 18 0 36 22 0 0 0 4 5 7 0.82 inf 116 D -4 -4 -1 8 -6 -3 -1 -4 -4 -5 -6 -3 -5 -6 -4 -3 -3 -6 -5 -5 0 0 0 96 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.21 inf 117 R 0 3 1 0 -3 2 2 -2 -1 -2 -2 1 -1 -3 -2 0 0 -3 -3 -1 9 21 7 5 0 11 19 2 0 1 4 6 1 0 0 3 6 0 0 4 0.27 inf 118 I -3 5 -3 -4 -4 -2 -3 -4 -3 5 -1 0 -1 -2 -4 -3 -2 -4 -3 0 0 42 0 0 0 0 0 0 0 41 3 5 1 0 0 0 1 0 0 4 0.83 inf 119 L 1 -3 -4 -4 1 -3 -4 -4 -3 -1 3 -3 7 2 -4 0 -2 -2 -1 -1 11 0 0 0 3 0 0 0 0 0 30 0 38 8 0 6 0 0 1 0 0.72 inf 120 Y -3 -3 -3 -4 -3 -2 -4 -4 0 2 1 -3 1 3 -4 -3 -1 -1 6 1 0 0 1 0 0 2 0 0 1 12 16 0 4 11 0 1 3 0 37 11 0.68 inf 121 E 0 1 2 1 -3 0 3 -1 -1 -2 -2 0 0 -3 -2 1 0 -4 -3 -2 6 7 11 8 0 2 31 4 0 3 2 2 4 0 0 15 3 0 0 1 0.31 inf 122 S 3 -3 -2 -3 -2 -2 -2 -2 -3 0 2 -2 0 -2 -3 3 -1 -3 -1 0 36 0 0 0 0 0 0 1 0 4 26 0 2 0 0 24 0 0 1 3 0.41 inf 123 Q -3 -1 1 -3 -5 8 -1 -4 1 -3 -4 -1 -3 -5 -4 -2 -3 -4 -4 -4 0 0 8 0 0 84 0 0 3 1 0 0 0 0 0 1 0 0 0 0 1.83 inf 124 R -4 8 -3 -4 -6 -2 -3 -5 -3 -6 -5 0 -4 -6 -5 -4 -4 -6 -5 -5 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.34 inf 125 Q -4 -2 -3 -3 -6 9 -1 -5 -1 -5 -5 -1 -3 -6 -4 -3 -3 -5 -4 -5 0 0 0 0 0 97 0 0 1 1 0 0 0 0 0 0 1 0 0 0 2.33 inf 126 G -2 -4 -3 -4 -5 0 -4 7 -4 -6 -6 -1 -5 -6 -4 -3 -4 -5 -5 -5 0 0 0 0 0 4 0 88 0 0 0 4 0 0 0 0 0 0 0 0 1.76 inf 127 R -3 7 -3 -1 -5 0 -2 -4 -3 -2 -4 3 -3 -5 -4 -3 -3 -5 -4 -3 0 69 0 4 0 3 0 0 0 4 1 18 0 0 0 0 0 0 0 1 1.35 inf 128 I -3 -4 -4 -5 -3 -4 -4 -5 1 5 2 -4 3 -1 -4 -3 1 -4 -3 2 0 0 0 0 0 0 0 0 4 49 19 0 9 1 0 0 11 0 0 7 0.72 inf 129 S -1 -3 -2 -3 -3 -2 -3 3 -3 -4 -3 -3 -3 -4 -3 6 -1 -5 -4 -1 1 0 0 0 0 0 0 23 0 0 2 0 0 0 0 67 1 0 0 4 0.99 inf 130 F -4 -5 -5 -5 -4 -5 -5 -5 -4 -3 -2 -5 -2 8 -1 -4 2 -2 0 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 80 4 0 13 0 0 0 1.77 inf 131 Y -3 -4 -4 -5 -5 -4 -4 -5 -1 0 -3 -4 -2 1 -5 -1 -4 -1 9 -3 2 0 0 0 0 0 0 0 0 5 0 0 0 2 0 4 0 0 84 0 2.12 inf 132 M 2 -3 -4 -4 -3 -3 -4 -3 -4 0 1 -3 8 -2 0 -1 -2 -4 -3 0 17 0 0 0 0 0 0 2 0 5 8 0 55 0 4 4 0 0 0 4 1.00 inf 133 T -1 -2 -2 -3 -3 2 -2 0 -3 -3 -3 0 -3 -4 5 -1 4 -4 -3 0 2 0 0 0 0 14 0 6 0 0 1 7 0 0 27 2 32 0 0 8 0.67 inf 134 N 1 -1 3 -2 4 -2 -2 -2 2 -3 -1 -2 0 0 -3 3 1 -3 -1 -2 9 4 17 0 13 0 0 1 7 0 5 0 3 5 0 26 7 0 1 1 0.33 inf 135 Y 2 0 -2 -2 -2 0 0 -2 0 -1 0 -1 0 1 -2 0 1 -2 3 -1 20 5 1 2 0 4 6 1 1 3 11 2 1 6 0 7 13 0 17 1 0.16 inf 136 G -1 -4 -3 -4 -5 -4 -4 7 -4 -6 -6 -4 -5 -5 -4 -2 -4 -5 -5 -5 4 0 0 0 0 0 0 93 0 0 0 0 0 0 0 0 0 0 0 0 1.93 inf 137 E -3 0 -2 -1 -5 4 6 -1 -1 -5 -5 -1 -4 -5 -3 -2 -3 -5 -4 -4 0 4 0 0 0 22 66 4 1 0 0 0 0 0 0 0 0 0 0 0 1.28 inf 138 E -3 -3 -3 -1 -6 0 7 -1 -3 -5 -5 -2 -4 -5 0 -3 -3 -5 -4 -5 0 0 0 0 0 1 88 4 0 0 0 0 0 0 4 0 1 0 0 0 1.66 inf 139 G 5 -4 -3 -4 -1 -3 -3 4 -4 -4 -4 -3 -3 -4 -3 -1 -2 -4 -4 -3 67 0 0 0 1 0 0 29 0 0 0 0 0 0 0 0 0 0 0 0 1.10 inf 140 T 2 -1 -2 -3 2 -2 -2 -3 -3 2 -1 -2 1 -2 -3 1 3 -4 -3 1 18 4 1 0 4 0 0 0 0 19 4 0 5 0 0 14 21 0 0 8 0.27 inf 141 H 0 -2 0 0 1 4 -1 0 4 -1 -1 -1 -1 -3 -2 1 -1 3 -2 0 9 0 4 4 3 26 0 5 13 3 4 0 2 0 1 10 2 4 0 8 0.25 inf 142 V -1 -4 -4 -4 2 -4 -4 -2 -4 4 1 -4 0 0 -4 -2 -1 -4 -2 4 2 0 0 0 5 0 0 4 0 26 11 0 1 3 0 1 3 0 0 43 0.58 inf 143 G 3 -1 -3 -3 -1 -3 -3 6 -4 -4 -4 -3 -4 -5 -3 -1 -3 -4 -4 -4 30 4 0 0 1 0 0 62 0 0 0 0 0 0 0 1 0 0 0 0 1.16 inf 144 S 0 -3 -2 -2 -1 0 -2 1 0 -2 -3 -2 -2 0 -3 5 1 -4 -3 -2 6 0 0 0 1 5 0 9 3 2 1 0 0 5 0 60 6 0 0 2 0.63 inf 145 A 5 0 -3 -3 -2 0 -2 0 1 -2 -1 -2 -1 -3 -3 1 -1 -4 -3 -1 61 6 0 0 0 4 0 5 4 0 4 0 1 1 0 6 3 0 0 3 0.58 inf 146 A 4 -1 -2 -3 -2 -2 -2 1 1 -2 0 -1 2 1 -2 0 -2 -3 0 -2 44 2 0 0 0 0 0 8 4 1 10 4 6 9 0 7 0 0 4 0 0.31 inf 147 A 6 -1 -4 -4 -3 -2 -3 0 -4 -1 -3 -3 -2 -4 -2 -1 -2 -5 -4 -1 80 4 0 0 0 1 0 5 0 4 1 0 1 0 1 0 0 0 0 3 1.04 inf 148 L -3 -4 -2 -5 -3 -4 -1 -5 -4 0 6 -4 2 -2 -5 -4 -2 -1 -3 0 0 0 3 0 0 0 4 0 0 2 82 0 3 0 0 0 1 1 0 4 1.04 inf 149 D 0 1 1 3 -3 0 2 0 0 -4 -3 0 -3 -4 1 1 0 -4 -3 -3 9 6 5 22 0 2 19 6 2 0 1 6 0 0 7 9 6 0 0 0 0.34 inf 150 N 0 0 1 1 -3 0 0 0 -2 -2 -2 2 0 -3 4 1 -1 -4 -3 -2 5 4 6 9 0 4 5 5 0 2 3 15 3 0 22 14 1 0 0 1 0.35 inf 151 T -1 1 0 3 -4 1 2 2 0 -3 -4 0 -3 -4 -3 0 1 -4 -3 -2 2 8 4 21 0 7 17 17 2 0 0 3 0 0 0 4 11 0 0 4 0.35 inf 152 D -4 -4 -1 8 -6 -3 -1 -4 -4 -5 -6 -3 -5 -5 -4 -3 -4 3 -5 -5 0 0 0 92 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 2.11 inf 153 L -3 -3 -4 -4 -3 -2 -1 -4 0 0 1 -3 5 1 -2 -3 -2 8 0 2 1 0 0 0 0 0 5 0 3 3 14 0 23 7 2 0 2 21 1 17 0.72 inf 154 V -1 -3 0 -3 3 -3 -3 -3 -3 4 1 -3 2 -2 -3 -1 -1 -3 -2 3 2 0 5 0 7 0 0 1 0 29 11 0 6 1 0 5 1 0 0 31 0.44 inf 155 F -3 -4 -4 -5 -4 -4 -4 -4 -3 -2 1 -4 2 7 0 -4 -3 0 3 -1 1 0 0 0 0 0 0 0 0 0 12 0 5 59 4 0 1 1 10 3 1.12 inf 156 G 3 -4 -4 -4 3 -3 -3 1 -4 -4 -3 -3 -3 -5 6 -1 -2 -5 -4 -3 27 0 0 0 6 0 0 12 0 0 2 0 0 0 49 2 1 0 0 0 1.22 inf 157 Q -1 0 -2 -3 0 6 -1 0 3 -4 -4 -1 -3 -4 -3 1 2 -4 -2 -4 2 4 0 0 2 48 0 8 7 0 0 0 0 0 0 12 16 0 1 0 0.77 inf 158 Y -4 -4 -5 -6 -5 -4 -5 -6 -1 -4 0 -5 -3 1 -1 -4 -4 -1 9 -4 0 0 0 0 0 0 0 0 0 0 9 0 0 1 4 0 0 0 85 0 2.20 inf 159 R -4 8 -3 -4 -6 -2 -3 -5 -3 -6 -5 -1 -4 -5 2 -3 -4 -5 -4 -5 0 88 0 0 0 0 0 0 0 0 0 0 0 0 11 0 0 0 0 0 1.94 inf 160 E -3 -2 -2 3 -5 3 6 -1 -2 -5 -5 -1 -2 -5 -3 -1 -3 -5 -4 -3 0 0 0 15 0 13 61 4 0 0 0 2 1 0 0 3 0 0 0 2 1.07 inf 161 A 1 -2 -1 -2 -3 3 -1 -1 4 -1 0 -2 -1 -2 1 0 0 -3 1 0 18 0 1 0 0 20 2 4 15 2 8 0 1 0 7 4 5 0 4 9 0.25 inf 162 G 1 -4 -2 -3 -4 -3 -4 6 -4 -5 -5 -2 -4 -5 1 0 -2 -5 -5 -4 12 0 0 0 0 0 0 71 0 0 1 2 0 0 7 5 1 0 0 1 1.24 inf 163 V 2 -3 -4 -4 -2 1 -3 -3 -4 2 1 -3 0 -2 -3 -2 -1 1 -3 4 22 0 0 0 0 7 0 1 0 8 10 0 1 1 0 1 1 2 0 46 0.49 inf 164 L -1 -4 -4 -5 0 -3 -4 -3 -4 1 5 -3 2 2 -4 -3 -2 0 -1 -1 6 0 0 0 2 0 0 2 0 5 65 1 5 7 0 1 2 1 1 1 0.68 inf 165 M -2 -2 -4 -4 -3 0 -3 -4 -1 2 3 -2 5 0 -4 -3 -1 -2 -1 1 3 2 0 0 0 4 0 0 2 15 34 2 25 4 0 0 2 0 1 6 0.53 inf 166 Y 1 -3 -3 -4 -2 0 -2 -4 1 -2 -1 -3 -1 0 -4 -2 -1 8 5 0 14 0 1 0 1 6 2 0 4 0 4 0 1 2 0 2 5 27 25 7 0.93 inf 167 R -3 7 -2 -2 -5 0 -2 -4 4 -5 -3 1 -2 0 -4 -2 -3 -5 -3 -5 1 71 0 2 0 2 0 1 11 0 2 4 1 4 0 1 0 0 0 0 1.35 inf 168 D -2 -4 -2 3 -5 -2 -2 6 -4 -6 -6 -3 -5 -5 -4 -1 -4 -5 -5 -5 0 0 1 15 0 1 1 78 0 0 0 0 0 0 0 2 0 0 0 0 1.54 inf 169 Y -3 -2 -4 -5 -1 -2 -4 -5 0 -1 1 -4 2 5 -5 -4 -3 3 6 0 1 2 0 0 1 2 0 0 2 2 13 0 6 33 0 0 0 3 30 5 0.88 inf 170 P -2 -2 -2 -1 -4 -2 -2 -2 -2 -3 -4 -2 -4 -5 6 2 4 -5 -4 -3 1 1 0 2 0 0 1 2 1 0 0 2 0 0 41 15 33 0 0 0 1.09 inf 171 L -2 -4 -5 -5 -3 -4 -4 -5 -4 2 5 -4 3 -1 -3 -3 -1 -2 0 1 1 0 0 0 0 0 1 0 0 8 69 0 6 1 1 0 4 0 3 5 0.83 inf 172 E -1 -1 -1 4 -3 1 2 -3 -1 -1 -1 1 -2 -2 -1 -1 0 -3 -1 0 3 2 1 27 0 7 17 0 1 3 4 9 0 1 2 3 4 0 3 11 0.27 inf 173 L -1 0 1 3 -4 4 2 -3 -1 -3 0 0 -1 -4 -2 -1 0 -4 -2 -3 2 4 8 19 0 25 15 0 1 0 12 3 2 0 1 3 4 0 0 0 0.40 inf 174 F 0 -4 -4 -4 -2 -3 -3 -4 -3 1 1 -3 4 5 -4 -2 1 -2 1 0 10 0 0 0 0 0 1 0 0 8 9 0 13 38 0 0 11 0 3 6 0.57 inf 175 M -1 -4 -4 -5 -1 -3 -4 -5 -4 1 2 -4 7 3 -4 -3 -2 -3 -1 1 6 0 0 0 1 0 0 0 0 8 16 0 45 13 0 0 2 0 1 7 0.90 inf 176 A 0 -2 4 1 3 0 -1 -1 0 -2 1 -2 -2 -3 -2 1 -1 -4 -3 -2 11 1 30 8 8 5 1 3 2 0 19 0 0 0 1 11 0 0 0 0 0.33 inf 177 Q -3 -1 -2 -2 -5 7 -1 -3 1 -5 -4 -2 -3 1 -4 -3 -3 2 3 -4 0 2 1 1 0 69 1 1 2 0 0 0 0 6 0 1 0 2 13 0 1.38 inf 178 C -2 -4 -3 -5 8 -4 -4 -4 -4 2 2 -4 1 -2 -4 0 -2 6 -2 -1 2 0 1 0 37 0 0 0 0 11 21 0 5 1 0 8 1 11 1 2 0.99 inf 179 Y -3 1 -2 -5 -2 -3 -4 -4 -2 -1 0 -2 4 6 -5 -3 -3 -1 5 -2 1 8 3 0 1 0 0 1 0 2 6 1 12 37 0 1 0 0 26 0 0.89 inf 180 G 2 -3 -2 -3 -2 -1 -3 5 -3 -5 -5 -3 -4 -4 -3 3 -2 -4 -2 -4 15 0 0 0 1 2 0 55 0 0 0 0 0 0 0 24 1 0 2 0 0.96 inf 181 N -3 0 7 0 -5 -2 -1 -3 4 -5 -5 -2 -4 -5 -2 -1 1 -5 -3 -4 1 5 65 2 0 0 2 0 12 0 0 0 0 0 1 2 9 0 0 0 1.28 inf 182 I 1 0 -1 -1 0 0 2 -2 2 -1 -2 1 -1 0 -2 0 -1 -3 -1 0 16 5 2 1 3 2 22 1 7 3 0 12 1 6 1 6 2 0 1 9 0.15 inf 183 S 0 1 1 1 -1 0 1 1 0 -2 0 1 -1 -1 -2 1 -1 -2 -1 -1 7 6 5 9 1 3 13 9 3 1 12 7 1 2 1 13 1 0 3 2 0.08 inf 184 D -2 -1 0 7 -1 -2 0 -1 -2 -3 -3 -2 -3 -3 -2 -1 -2 -3 -3 -3 2 3 2 72 1 1 2 3 0 1 3 1 0 1 1 2 1 0 1 1 1.17 inf 185 L -1 -1 0 -1 -1 0 0 -2 0 -1 1 0 -1 -1 5 -1 -1 -2 0 -1 3 3 4 3 1 5 7 3 2 3 15 5 1 1 30 3 3 0 5 2 0.35 inf 186 G 0 -2 -1 -2 0 -2 -2 5 -2 -1 1 -2 0 -2 -2 -1 -2 -1 -3 -2 5 2 3 2 2 1 1 50 0 3 18 1 3 1 1 3 1 1 1 2 0.50 inf 187 K -2 3 -2 -2 -4 1 -1 -2 1 -4 -3 6 -2 -4 -2 -1 -2 -4 -3 -3 1 13 1 1 0 3 1 2 3 1 3 65 1 0 1 2 1 0 0 1 0.93 inf 188 G -2 -5 -3 -4 -5 -4 -5 7 -5 -3 -6 -4 -5 -5 -5 -3 -4 -5 -5 -5 1 0 0 0 0 0 0 96 0 2 0 0 0 0 0 0 0 0 0 0 2.06 inf 189 R -3 7 2 -3 0 -1 -2 -2 -2 -4 -4 1 -3 -5 -2 -1 -3 -5 -4 -4 1 72 9 0 2 0 0 3 0 1 0 4 0 0 1 5 1 0 0 0 1.29 inf 190 Q -3 0 2 -2 -5 8 0 -4 -1 -5 -4 -1 -2 -2 -4 -2 -3 -4 -2 -2 1 4 10 1 0 74 1 0 1 0 0 1 1 2 0 1 0 0 1 2 1.43 inf 191 M -3 -4 -5 -5 -4 -3 -4 -5 -4 1 2 -4 9 -1 -1 -3 -3 -4 0 -1 1 0 0 0 0 0 0 0 0 5 15 0 67 2 4 1 1 0 3 1 1.51 inf 192 P -4 -5 -5 -3 -1 -4 -2 -4 -5 -5 -5 -4 -1 -6 8 -4 -4 -6 -6 -5 0 0 0 1 1 0 2 1 0 0 0 0 2 0 92 0 0 0 0 0 2.68 inf 193 V -1 -3 -2 -1 0 -2 1 -2 -3 4 -1 -3 0 -2 -3 -2 -1 -4 -3 4 2 0 1 4 2 0 10 3 0 28 1 0 2 0 0 2 3 0 0 40 0.44 inf 194 H -3 -2 -1 -3 1 -2 -2 1 9 -3 -2 -3 3 -2 -4 -2 -3 -4 -1 -3 1 1 2 1 3 0 1 11 59 1 4 1 11 1 1 3 1 0 0 1 1.35 inf 195 Y -3 -3 -3 -3 -3 -2 -2 -3 1 -2 -2 -2 -1 2 -2 -3 -3 0 8 -2 1 1 1 1 0 2 3 1 2 2 3 2 1 5 2 1 1 0 68 3 1.37 inf 196 G 0 -2 -1 -2 -1 -2 -2 5 -2 -3 -3 -2 -2 -2 -1 2 0 -3 -3 -3 3 1 1 1 1 1 1 56 0 2 2 1 1 2 2 19 5 0 1 1 0.76 inf 197 C 1 -2 -1 -1 4 -1 -1 -1 -2 -2 -2 -1 -2 -2 -1 4 0 2 -1 -2 8 1 1 2 12 1 3 3 0 1 2 4 1 1 3 48 2 3 2 2 0.45 inf 198 K -1 3 0 -2 -4 0 1 -2 -1 -3 -2 5 -2 -4 0 -1 -1 -3 -3 -3 5 18 5 1 0 3 10 1 1 1 2 43 0 0 4 2 2 0 0 1 0.55 inf 199 E 0 0 0 4 -4 0 3 -1 -1 -3 -3 1 -3 -3 -1 -1 -2 -3 -2 -3 8 5 3 27 0 2 28 4 1 1 2 11 0 0 3 1 1 0 2 1 0.45 inf 200 R -1 0 -3 -4 -2 -2 -3 -1 3 0 3 -1 0 -1 -2 -2 -1 -3 1 1 5 5 0 0 1 1 0 4 12 1 43 3 0 1 1 2 2 0 4 14 0.28 inf 201 H -3 0 6 -1 -5 -1 -2 1 6 -5 -5 0 -4 -5 -4 -1 -3 -5 -2 -5 1 4 52 1 0 1 0 13 22 0 0 5 0 0 0 3 0 0 0 0 1.14 inf 202 F -1 -4 -4 -5 -3 -2 -4 -5 -2 3 0 -4 1 6 -5 -3 -2 -1 3 1 5 0 0 0 0 1 0 0 1 18 3 0 3 46 0 0 2 0 11 9 0.85 inf 203 V -2 -3 -3 -4 -3 0 -3 -2 4 0 0 -2 2 5 -4 -3 -2 -2 1 3 1 0 0 0 0 6 0 2 15 2 8 1 7 27 0 0 1 0 3 26 0.51 inf 204 T -1 -3 -2 -3 -3 -3 -3 -3 -3 -3 -4 -3 0 -4 3 3 6 -5 -1 -2 3 0 0 0 0 0 0 0 0 0 0 0 2 0 14 22 56 0 2 0 0.97 inf 205 I -2 -5 -5 -5 -3 -4 -5 -5 -5 6 0 -4 0 -2 2 -4 -2 0 -3 3 2 0 0 0 0 0 0 0 0 63 3 0 1 0 13 0 1 1 0 16 1.03 inf 206 S 1 -3 -2 -3 0 2 -2 -2 -3 -5 -5 -2 -4 -5 -3 6 0 -5 -4 -4 10 0 0 0 2 9 0 1 0 0 0 0 0 0 0 75 3 0 0 0 1.15 inf 207 S 0 -3 -2 -3 -3 -3 -3 2 -3 1 -3 -3 -3 -4 -2 5 0 -5 -4 1 3 0 0 0 0 0 0 15 0 12 0 0 0 0 1 56 3 0 0 10 0.66 inf 208 P -3 -4 3 -3 -1 -3 -3 -4 -4 1 -3 -3 -2 -5 7 -3 1 -6 -5 -3 0 0 15 0 1 0 0 0 0 9 2 0 1 0 63 0 9 0 0 0 1.56 inf 209 L -3 -4 -5 -3 -3 -4 -5 -6 -5 4 5 -5 0 -2 -5 -4 -3 -4 -3 0 0 0 0 2 0 0 0 0 0 29 67 0 0 0 0 0 0 0 0 2 1.08 inf 210 A 5 -4 -1 -3 -3 -3 -3 3 -4 -4 -3 -3 -3 -4 -3 0 0 -5 -4 -3 63 0 2 0 0 0 0 27 0 0 1 0 0 0 0 2 5 0 0 0 0.96 inf 211 T 1 -4 -3 -4 -3 -3 -3 -4 -4 -3 -4 -3 -3 -5 -3 1 7 -5 -4 -2 9 0 0 0 0 0 0 0 0 0 0 0 0 0 1 9 81 0 0 1 1.44 inf 212 Q -4 0 -2 -1 -6 8 -1 -5 0 -6 -5 -1 -3 -6 -4 -3 -2 -5 -4 -5 0 2 1 2 0 90 0 0 2 0 0 2 0 0 0 0 1 0 0 0 2.07 inf 213 I -3 -4 -5 -5 -3 -4 -4 -5 -3 5 3 -4 3 2 -4 -4 -2 -3 2 1 0 0 0 0 0 0 0 0 0 41 24 0 10 6 0 0 2 0 10 6 0.72 inf 214 P -3 -4 -3 -4 -4 -4 -4 -3 -4 0 -2 -3 -3 -5 8 -1 -2 -5 -5 0 0 0 1 0 0 0 0 2 0 7 4 0 0 0 71 4 2 0 0 8 1.71 inf 215 Q -3 -2 -2 -3 -5 7 -1 -4 7 -5 -5 -2 -3 -5 -3 -3 -3 -5 -3 -4 1 0 1 0 0 64 0 0 31 0 0 0 0 0 1 0 0 0 0 1 1.79 inf 216 A 6 -3 -3 0 -3 -2 -1 -1 -3 -3 -3 -3 -3 -4 -3 0 0 -4 -4 -2 79 0 0 5 0 0 3 2 0 0 0 0 0 0 0 2 5 0 0 1 1.02 inf 217 V 3 -3 -3 -3 -2 -3 -3 -3 -4 1 -2 -3 -1 -3 -3 1 1 -4 -3 4 29 0 0 0 0 0 0 0 0 5 0 0 1 0 0 12 10 0 0 42 0.54 inf 218 G -2 -5 -3 -4 -5 -4 -5 7 -4 -6 -6 -4 -5 1 -5 -1 -4 -5 -4 -5 0 0 0 0 0 0 0 90 0 0 0 0 0 6 0 3 0 0 0 0 1.87 inf 219 A 4 -3 -3 -4 1 -3 -3 0 -3 -2 -2 -3 -2 0 -3 0 -1 6 1 1 42 0 0 0 3 0 0 6 0 1 1 0 0 5 0 8 3 14 5 12 0.55 inf 220 A 6 -4 -3 -4 -3 -1 -3 2 -4 -3 -4 -3 -3 -4 0 -1 -2 -5 -4 -1 75 0 0 0 0 2 0 14 0 0 0 0 0 0 3 1 0 0 0 4 1.03 inf 221 Y -4 -4 -5 -6 -2 -4 -5 -5 -2 -2 0 -4 5 1 0 -4 -4 7 7 -3 0 0 0 0 1 0 0 0 0 1 10 0 17 2 4 0 0 14 50 0 1.45 inf 222 A 6 -3 -3 -4 -3 -2 -3 2 -4 -4 -4 0 -2 -4 -3 1 -2 -5 -4 -2 74 1 0 0 0 0 0 12 0 0 0 5 1 0 0 7 0 0 0 1 1.01 inf 223 A 1 -2 -2 -2 0 0 0 -2 -2 0 2 -2 1 2 0 1 -1 -1 0 0 12 0 1 0 2 5 6 1 0 3 25 0 5 10 3 19 1 0 2 5 0.14 inf 224 K 1 2 -2 -2 -4 0 -1 -3 -3 -4 -4 6 -2 -4 1 -2 -2 -4 -4 -4 15 11 1 1 0 1 1 0 0 0 0 60 1 0 7 0 1 0 0 0 0.89 inf 225 R -2 2 -3 -4 -3 -2 -3 -4 -3 3 3 0 3 -1 -4 -3 -2 -1 1 0 1 17 0 0 0 1 0 0 0 18 35 6 12 1 0 0 1 1 5 2 0.41 inf 226 A 1 3 -1 1 -3 3 0 -2 -2 -4 -3 3 -2 -4 -2 0 -1 -4 -3 -3 16 20 2 9 0 13 4 1 0 0 1 26 0 0 1 5 2 0 0 0 0.44 inf 227 N -1 2 3 -1 -4 1 -2 5 -1 -5 -4 1 -3 -4 -3 -1 -2 -4 -4 -4 1 10 17 3 0 6 1 47 1 0 0 11 0 0 0 1 0 0 0 0 0.73 inf 228 A 0 -1 1 3 -3 0 3 -2 -1 -3 -3 2 -2 -4 1 0 0 -4 -3 -3 9 1 6 20 0 2 21 1 1 0 1 20 0 0 5 7 5 0 0 1 0.39 inf 229 N -1 1 2 3 -3 0 0 0 -1 -4 -4 2 -3 -4 1 0 1 -4 -3 -3 4 10 12 23 0 3 4 9 0 0 0 13 0 0 6 5 11 0 0 0 0.34 inf 230 R 1 4 2 -2 -3 1 -1 -2 0 -3 -2 2 -1 -4 -3 0 0 -4 -3 -3 17 35 11 1 0 7 2 1 2 1 2 10 2 0 0 4 4 0 0 0 0.43 inf 231 V 0 -4 -4 -4 5 -4 -4 -4 -4 4 0 -4 -1 -2 -4 -3 -2 -4 -3 4 8 0 0 0 15 0 0 0 0 29 6 0 0 0 0 0 1 0 0 40 0.76 inf 232 V 4 -3 -3 -1 0 -3 -3 -2 -3 0 -2 -3 -2 -1 0 0 1 -4 -3 3 43 0 0 4 2 0 0 0 0 3 0 0 0 2 3 6 7 0 0 28 0.46 inf 233 I 2 -4 -4 -4 -1 -3 -4 -4 -4 4 1 -3 1 -2 0 -1 -1 -4 -3 3 18 0 0 0 1 0 0 0 0 36 13 0 2 0 4 4 2 0 0 20 0.48 inf 234 C 2 -4 -3 -4 8 -3 -4 -1 1 -2 -3 -3 0 -4 -4 -1 3 -4 -3 1 22 0 0 0 33 0 0 5 4 0 0 0 3 0 0 1 21 0 0 10 0.84 inf 235 Y -4 -4 -5 -6 -2 -4 -5 -2 2 -3 -1 -5 -3 3 -6 -4 -3 7 8 -3 0 0 0 0 1 0 0 3 4 0 5 0 0 11 0 0 1 13 62 0 1.71 inf 236 F -3 -5 -5 -5 0 -5 -5 -5 -4 2 1 -5 0 7 -5 -4 0 -2 0 0 1 0 0 0 2 0 0 0 0 12 9 0 1 63 0 0 8 0 0 4 1.21 inf 237 G -2 -5 -3 -4 -5 -4 -5 7 -5 -6 -6 -4 -5 -1 -1 -3 -4 -5 -5 -6 0 0 0 0 0 0 0 93 0 0 0 0 0 3 3 0 0 0 0 0 1.96 inf 238 E -3 -3 -1 6 -5 -1 5 -4 -3 -5 -5 -2 -4 -5 -3 -2 -3 -5 -4 -5 0 0 0 51 0 0 45 0 0 0 0 0 0 0 0 0 0 0 0 0 1.44 inf 239 G -2 -4 -3 -3 -4 -4 -4 7 -4 -2 -5 -4 -4 -5 -4 -1 -3 -4 -5 -5 0 0 0 0 0 0 0 89 0 3 0 0 0 0 0 4 0 0 0 0 1.76 inf 240 A 5 -3 -3 -3 -1 0 -2 2 -3 -3 -3 -2 -3 -4 -3 1 -1 -4 -3 -1 64 0 0 0 1 4 0 13 0 0 0 0 0 0 0 10 3 0 0 3 0.76 inf 241 A 4 -1 -2 -3 -2 -2 -2 -2 -3 -3 -3 -2 -3 -4 0 1 4 -4 -3 -2 43 3 0 0 0 0 0 0 0 0 0 0 0 0 4 10 37 0 0 0 0.73 inf 242 S 2 -3 -2 -3 -3 -2 -1 -3 -3 -4 -5 -3 -4 0 -3 6 -1 -5 -4 -4 15 0 0 0 0 0 3 0 0 0 0 0 0 4 0 77 0 0 0 0 1.19 inf 243 E -2 1 -2 -1 -6 2 6 -4 -1 -5 -5 -1 -4 -5 -3 0 -1 -5 -4 -5 1 8 0 0 0 8 73 0 1 0 0 1 0 0 1 5 2 0 0 0 1.28 inf 244 G -1 -1 -1 -3 -5 -3 -4 7 -1 -6 -6 -3 -5 -5 -3 1 -3 -5 -5 -5 3 4 1 0 0 0 0 80 2 0 0 0 0 0 1 9 0 0 0 0 1.47 inf 245 D -4 -4 -1 8 -6 -3 -1 -4 -4 -6 -6 -3 -6 -6 0 -1 -4 -7 -6 -6 0 0 0 91 0 0 1 0 0 0 0 0 0 0 4 3 0 0 0 0 2.08 inf 246 A 2 -1 -5 -5 -2 -5 -5 -4 -4 -3 -2 -4 -3 8 -5 -3 -3 0 0 -3 24 3 0 0 1 0 0 0 0 0 0 0 0 69 0 0 1 1 1 0 1.45 inf 247 H -4 -3 -3 -4 -5 -2 -3 -5 10 -5 -5 -4 -4 -2 -5 -3 -4 -1 4 0 1 0 0 0 0 0 0 0 76 0 0 0 0 0 0 1 0 1 13 8 2.24 inf 248 A 4 0 -2 -2 -3 -1 3 -1 -3 -3 -2 -2 -3 -4 -2 1 0 -4 -3 -2 49 4 0 0 0 0 24 3 0 0 3 0 0 0 0 7 6 0 0 2 0.55 inf 249 G 4 -4 -3 -3 -3 -3 -1 5 -4 -4 -4 -3 -4 -1 -3 -1 -3 -4 -4 -3 49 0 0 0 0 0 3 43 0 0 0 0 0 3 0 1 0 0 0 0 1.02 inf 250 F -3 -4 -5 -5 0 -4 -4 -5 -4 1 4 -4 4 3 -1 -4 -1 -3 -2 0 0 0 0 0 2 0 0 0 0 6 54 0 12 15 3 0 4 0 0 3 0.72 inf 251 N -3 -3 7 -1 -4 -2 -3 -2 -2 -4 -2 0 -3 -5 -4 0 1 -6 -4 -1 0 0 70 0 0 0 0 2 0 0 5 4 1 0 0 4 10 0 0 4 1.23 inf 252 F -2 -5 -5 -6 2 -5 -5 -5 -4 1 0 -5 3 8 -5 -4 -3 -1 0 -2 4 0 0 0 4 0 0 0 0 7 4 0 9 68 0 1 1 0 0 1 1.41 inf 253 A 6 -3 -3 -4 -3 0 -3 0 -4 -4 -4 -1 -3 -5 -3 -1 -2 -5 -4 -3 86 0 1 0 0 3 0 5 0 0 0 3 0 0 0 2 0 0 0 0 1.26 inf 254 A 4 -3 -2 -3 -3 -2 -2 3 1 -4 -4 -1 0 -4 -3 3 -1 -4 -3 -3 46 0 0 0 0 0 0 22 4 0 0 3 3 0 0 21 1 0 0 0 0.66 inf 255 T 0 -3 -3 -4 -3 -1 -3 -4 -4 -1 -2 -1 -2 -4 -4 -2 5 -5 -3 5 8 0 0 0 0 3 0 0 0 0 1 3 0 0 0 0 40 0 0 45 0.80 inf 256 L -1 2 -3 -4 -3 -2 -3 -4 1 -1 2 -2 1 3 -4 -3 -2 -1 4 0 4 12 0 0 0 1 0 0 3 1 28 1 3 15 0 0 2 0 20 7 0.43 inf 257 E -2 3 2 2 -4 1 2 0 0 -4 -4 3 -3 -4 -2 0 -2 -4 -3 -4 1 20 9 10 0 6 16 7 2 0 0 21 0 0 1 8 0 0 0 0 0.45 inf 258 C 3 -4 -3 -4 7 -3 -3 0 -4 -2 -2 -3 -3 -4 -2 1 1 -4 -4 1 33 0 0 0 29 0 0 5 0 1 1 0 0 0 2 11 9 0 0 10 0.75 inf 259 P -3 -1 -2 -4 -5 1 -3 -5 -2 -5 -2 -3 -4 -6 8 -3 -4 -6 -5 -5 0 3 2 0 0 8 0 0 1 0 4 0 0 0 81 0 0 0 0 0 2.21 inf 260 I 1 -4 -2 -4 1 -3 -3 -4 -4 2 -1 -3 -1 -3 0 0 2 -4 -3 4 12 0 2 0 3 0 0 0 0 14 1 0 1 0 4 5 13 0 0 46 0.51 inf 261 I -3 0 -5 -5 -3 -4 -5 -5 -5 6 1 -4 1 -2 -5 -4 -2 -4 -3 4 0 8 0 0 0 0 0 0 0 54 10 0 2 0 0 0 0 0 0 26 0.93 inf 262 F -2 -5 -5 -6 -4 -5 -5 -5 -4 0 1 -5 0 8 -5 -1 -4 0 1 -2 3 0 0 0 0 0 0 0 0 5 15 0 1 69 0 4 0 1 1 0 1.40 inf 263 F -3 -4 2 -4 0 -3 -2 -4 -3 2 1 -4 1 5 -4 -3 -3 -2 0 2 1 0 13 0 2 0 3 0 0 17 11 0 4 37 0 0 0 0 0 13 0.59 inf 264 C -2 -5 -2 -5 9 -5 -5 -2 1 1 -3 -5 -3 -4 0 -3 -3 -5 -4 3 2 0 3 0 56 0 0 3 3 8 0 0 0 0 4 0 0 0 0 20 1.53 inf 265 R -3 6 0 -3 -5 4 -1 -4 -2 -2 -2 0 -3 -4 -4 -3 -1 -5 -4 1 0 53 4 0 0 22 1 0 0 1 3 1 0 0 0 0 2 0 0 11 0.95 inf 266 N -3 -3 8 -1 -5 -2 -3 -3 -2 -6 -6 -3 -5 -1 -5 -1 -3 -6 -4 -6 1 0 92 0 0 1 0 0 0 0 0 0 0 3 0 3 0 0 0 0 2.10 inf 267 N -4 -3 8 0 -6 -3 -3 -1 -2 -6 -6 -3 -5 -6 -5 -2 -3 -7 -5 -6 0 0 93 3 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 2.21 inf 268 G -2 0 -1 -3 -3 4 -2 5 0 -2 -3 -1 -3 -3 -4 -2 -3 -4 -4 -4 0 5 2 0 0 27 0 56 2 3 2 1 0 1 0 1 0 0 0 0 0.98 inf 269 Y -5 -5 -5 -6 -5 -4 -5 -5 -2 -4 -2 -5 -3 4 -6 -5 -4 9 7 -4 0 0 0 0 0 0 0 0 0 0 3 0 0 14 0 0 0 29 49 0 1.99 inf 270 A 6 -4 -4 -4 -3 -3 -3 -2 3 -4 -4 -3 -3 -5 -3 -1 -2 -5 -4 -3 91 0 0 0 0 0 0 0 7 0 0 0 0 0 0 2 0 0 0 0 1.46 inf 271 I -4 -5 -5 -5 -4 -5 -6 -1 -6 8 -1 -5 -1 -3 -5 -5 -3 -5 -4 0 0 0 0 0 0 0 0 7 0 92 0 0 0 0 0 0 0 0 0 0 1.70 inf 272 S -1 -3 -2 -3 -4 -3 -3 -3 -4 -5 -5 -3 -4 -5 -3 7 -1 -5 -4 -4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 99 0 0 0 0 1.81 inf 273 T -2 -4 -3 -3 -3 -3 -3 -4 -4 -2 -3 -3 -2 -4 1 1 6 -5 -4 2 0 0 0 0 0 0 0 0 0 0 1 0 1 0 7 7 67 0 0 17 1.07 inf 274 P -3 -5 -4 -3 -3 -4 -4 -5 -1 -5 -5 -4 -4 3 8 -2 -3 -5 -1 -5 0 0 0 1 1 0 0 0 2 0 0 0 0 12 79 3 0 0 2 0 2.14 inf 275 T 0 1 -1 -3 -1 1 -2 -3 -2 0 -2 -1 -1 -1 1 1 3 -3 -1 1 7 10 1 0 1 9 0 0 0 6 1 0 1 3 7 12 30 0 2 11 0.27 inf 276 S 0 0 0 0 -2 1 2 1 1 -2 -1 0 -2 -3 1 2 0 -4 -2 -2 8 4 3 3 0 5 13 11 5 1 7 5 0 0 7 23 4 0 1 1 0.19 inf 277 E -2 1 -2 2 -4 1 4 -4 -1 1 -2 2 -1 -1 1 -1 -2 -4 -3 -2 0 9 0 10 0 3 38 0 1 11 1 11 1 3 7 3 0 0 0 2 0.43 inf 278 Q 1 1 -3 -3 -5 8 -1 -4 -2 -5 -5 -1 -3 -6 -4 -3 -3 -5 -4 -5 15 7 0 0 0 79 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.71 inf 279 Y -3 -1 -3 -4 -4 -3 -4 1 -1 -3 0 -3 1 3 -4 0 2 -1 6 -3 0 3 0 0 0 0 0 10 0 0 7 0 3 15 0 6 17 0 38 0 0.71 inf 280 R 3 4 -1 -3 -3 -1 -2 1 0 -4 -4 2 -2 -4 1 -1 -2 -4 -3 -2 28 28 2 0 0 0 0 12 2 0 0 16 1 0 7 2 1 0 0 1 0.48 inf 281 G 1 -3 -2 -3 -4 -2 -2 5 -2 -5 -5 -3 -4 -5 -3 3 -1 -5 -4 -4 12 0 0 0 0 1 2 53 1 0 0 0 0 0 0 27 3 0 0 0 0.96 inf 282 D -1 0 0 6 -4 -1 1 -3 -3 -4 -1 1 -3 -4 -1 -1 0 -5 -4 -3 4 4 2 52 0 2 8 1 0 0 7 8 0 0 3 3 7 0 0 0 0.71 inf 283 G 0 -4 -2 -3 -4 -3 -4 5 -4 -4 -4 -3 -4 -5 -4 -1 4 -5 -5 -3 7 0 0 0 0 0 0 55 0 0 0 0 0 0 0 0 38 0 0 1 1.18 inf 284 I 0 -5 -5 -5 -3 -5 -5 -5 -5 6 1 -4 -1 3 -5 -4 -3 -4 -1 2 7 0 0 0 0 0 0 0 0 62 10 0 0 14 0 0 0 0 1 7 0.96 inf 285 A 6 -4 -4 -4 -3 -3 -3 0 -4 -3 -3 -3 -3 -3 -3 -1 -2 -5 -3 0 86 0 0 0 0 0 0 5 0 1 2 0 0 1 0 0 0 0 0 6 1.24 inf 286 A 3 -2 -2 -1 -1 4 -1 1 -2 -1 -3 -2 -2 -4 1 2 0 -4 -3 -1 30 0 0 2 1 22 1 8 0 3 1 0 0 0 5 18 6 0 0 3 0.38 inf 287 R -4 7 0 -3 -6 -1 -2 -4 -3 -5 -5 4 -4 -5 -4 -3 -3 -5 -4 -5 0 63 4 0 0 0 1 0 0 0 0 32 0 0 0 0 0 0 0 0 1.50 inf 288 G 4 -4 -3 -3 -4 -3 -4 6 -4 -5 -5 -3 -4 -5 -4 0 -3 -5 -5 -4 37 0 0 0 0 0 0 57 0 0 0 0 0 0 0 6 0 0 0 0 1.21 inf 289 P -1 -2 -3 -3 -3 -1 -2 -4 0 2 1 -2 -1 -2 5 -1 -1 -4 -2 2 4 2 1 0 0 3 1 0 3 15 12 1 1 1 31 2 2 0 1 19 0.54 inf 290 G 4 -4 -3 -3 -3 -3 -3 5 -4 -5 -5 -3 -2 -5 -3 0 -3 -5 -5 -4 39 0 0 0 0 0 0 55 0 0 0 0 1 0 0 6 0 0 0 0 1.16 inf 291 Y -1 -4 -5 -6 1 -4 -5 -5 0 -4 -2 -5 -3 2 -5 -3 -4 -1 9 -2 6 0 0 0 3 0 0 0 1 0 4 0 0 6 0 1 0 0 79 2 1.95 inf 292 G -2 -4 -3 0 2 -4 -4 7 -2 -6 -6 -3 -5 -6 -5 -3 -4 -5 -5 -6 0 0 0 4 4 0 0 89 1 0 0 1 0 0 0 0 0 0 0 0 1.83 inf 293 I -3 -5 -5 -5 -3 -4 -5 -6 -5 6 1 -5 4 2 -5 -4 -3 -4 -2 1 0 0 0 0 0 0 0 0 0 64 8 0 13 10 0 0 0 0 0 5 1.13 inf 294 M 1 0 -1 1 -4 -1 1 -3 2 -2 -2 0 3 -3 4 -1 -1 -4 1 -2 12 6 2 11 0 1 9 0 6 0 1 5 13 0 25 1 2 0 5 1 0.43 inf 295 S 1 -3 -2 -3 -2 -2 -3 4 -3 -3 -4 -2 -3 -3 -3 3 3 -4 -3 -2 11 0 0 0 1 0 0 30 0 1 0 0 0 1 0 31 23 0 0 2 0.67 inf 296 I -2 -4 -5 -5 -3 -4 -3 -5 -5 6 2 -4 0 -1 -4 -4 -2 -4 -1 3 3 0 0 0 0 0 2 0 0 53 21 0 1 1 0 0 0 0 2 18 0.85 inf 297 R -4 7 -3 -4 -6 2 -2 -5 -3 -5 -2 0 -4 -5 0 -3 -4 -5 -4 -4 0 80 0 0 0 11 0 0 0 0 4 0 0 0 4 0 0 0 0 1 1.63 inf 298 V -3 -5 -5 -6 -1 -5 -5 -6 -5 1 -1 -5 -2 -2 -5 -4 -3 -5 1 7 0 0 0 0 1 0 0 0 0 5 0 0 0 1 0 0 0 0 4 89 1.49 inf 299 D -5 -4 -1 8 -6 -3 -1 -4 -4 -6 -6 -4 -6 -6 -4 -3 -4 3 -5 -6 0 0 0 96 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 2.30 inf 300 G -2 -5 -3 -4 -5 -4 -5 7 -5 -7 -6 -4 -5 -6 -5 -3 -4 -5 -6 -6 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 2.25 inf 301 N -3 -3 8 -1 -4 -1 -3 -2 -2 -4 -3 -3 4 -4 -4 -2 0 -5 -4 -4 1 0 76 0 0 1 0 1 0 0 1 0 13 0 0 1 4 0 0 0 1.54 inf 302 D -4 -4 -1 8 -6 -3 -1 -4 -4 -5 -6 -3 -5 -6 -4 -3 -3 -6 -5 -5 0 0 0 96 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.22 inf 303 V 1 -3 -3 -4 -2 -3 -3 -3 -3 2 1 -3 0 2 2 -2 -1 -3 1 3 14 0 0 0 0 0 0 1 0 13 11 0 1 11 11 0 2 0 4 31 0.34 inf 304 F -4 -3 -5 -6 -4 -4 -4 -5 -4 0 5 -5 0 5 -5 -4 -3 3 -1 -1 0 1 0 0 0 0 1 0 0 3 57 0 1 32 0 0 0 4 0 1 1.07 inf 305 A 7 0 -4 -4 -3 -3 -3 -2 -4 -4 -4 -3 -2 -5 -3 -1 -3 -5 -4 -3 95 4 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1.54 inf 306 V -1 -5 -5 -5 -2 -4 -5 -5 -5 0 -1 -4 1 -3 -5 -1 -1 -5 -4 7 5 0 0 0 1 0 0 0 0 1 0 0 4 0 0 4 1 0 0 85 1.31 inf 307 Y -4 0 -4 -5 -5 -3 -4 -5 4 -3 -1 -4 -1 1 -5 -4 -3 3 8 -3 0 5 0 0 0 0 0 0 12 0 6 0 1 3 0 0 1 4 67 1 1.68 inf 308 N 2 -1 3 -1 -3 1 1 -2 0 -3 -2 0 -1 -1 -3 0 -1 -3 1 -2 28 3 23 0 0 7 10 0 2 0 4 6 1 3 0 5 1 0 6 1 0.28 inf 309 A 5 -4 -4 -4 -1 -3 -2 -2 -4 -2 -3 -3 -3 -3 -3 -1 0 -4 1 2 68 0 0 0 1 0 1 1 0 0 0 0 0 0 0 0 5 0 5 18 0.85 inf 310 T 0 -3 -3 -3 -2 -3 -3 -4 -4 -1 -3 -3 2 -4 0 0 6 -5 -4 2 5 0 0 0 0 0 0 0 0 1 0 0 5 0 4 5 60 0 0 18 0.88 inf 311 K -1 4 -2 -3 -2 2 0 -3 1 -1 -2 5 -2 -4 -3 -1 -1 -4 -3 -3 3 23 0 0 1 10 2 1 3 4 4 43 0 0 0 3 2 0 0 1 0.63 inf 312 E 0 1 -1 0 -4 1 4 -1 -1 -3 -3 1 -2 -2 -3 -1 -1 6 -1 -3 7 7 1 4 0 5 36 5 1 1 2 11 1 1 0 2 2 15 1 0 0.57 inf 313 A 6 -4 -4 -4 3 -3 -3 -2 -4 -4 -4 -3 -2 -5 -3 -1 -3 -5 -4 -3 92 0 0 0 5 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 1.50 inf 314 R 1 7 -3 -4 -4 -1 -2 -4 -3 -2 -1 0 -2 -3 -4 -3 -2 -5 -4 1 11 66 0 0 0 0 1 0 0 2 5 2 0 0 0 0 1 0 0 11 1.05 inf 315 R -1 4 -1 2 -5 1 5 -3 -1 -5 -4 2 -3 -5 -3 -1 -2 -5 -4 -4 6 24 2 10 0 6 41 0 0 0 0 9 0 0 0 1 0 0 0 0 0.74 inf 316 R -2 6 -3 -4 -4 -1 -2 -4 -2 1 1 1 2 -1 -4 -3 -3 -4 1 -2 1 53 0 0 0 1 1 0 1 9 13 6 7 2 0 0 0 0 5 1 0.74 inf 317 A 6 -4 -4 -4 3 -3 -3 -2 -4 0 -3 -3 -3 -4 -3 -1 -1 -5 -4 -1 82 0 0 0 6 0 0 1 0 5 0 0 0 0 0 1 2 0 0 2 1.20 inf 318 V -2 4 -3 -4 -3 -2 -3 -4 -2 2 2 -1 -1 -2 -4 -2 -2 -4 -3 3 2 29 0 0 0 0 0 0 1 11 21 2 0 0 0 1 0 0 0 31 0.51 inf 319 A 2 1 2 0 -2 1 2 -1 0 -3 -3 1 -2 -4 -2 1 0 -4 -3 -1 26 10 11 4 0 5 15 2 2 0 1 8 0 0 0 8 5 0 0 5 0.24 inf 320 E -2 -2 3 -1 -3 1 4 4 1 -4 -4 -1 -3 -4 -2 -1 -1 -4 -3 -4 1 1 16 1 0 5 29 34 3 0 0 1 0 0 2 2 3 0 0 0 0.62 inf 321 N -1 -1 4 1 -3 1 2 1 2 -3 -1 0 -1 -2 -2 0 -2 -4 -3 -3 2 1 26 7 0 6 17 13 5 0 9 5 1 2 1 6 0 0 0 0 0.32 inf 322 Q -1 3 -2 -3 -2 3 0 4 -2 -4 -4 2 -3 -4 -3 -2 -2 3 -3 -4 2 17 0 0 1 16 4 40 0 0 0 13 0 0 0 1 1 4 0 1 0.69 inf 323 P -1 -5 -5 -4 -6 -4 -4 -4 -5 -6 -6 -4 -5 -7 9 -3 -4 -7 -6 -5 5 0 0 0 0 0 0 1 0 0 0 0 0 0 94 0 0 0 0 0 2.81 inf 324 F -1 -4 -3 -4 -2 -3 -4 -4 -4 1 -2 -3 0 3 -4 -1 4 3 -1 3 2 0 0 0 1 0 0 0 0 8 0 0 2 14 0 2 36 4 0 31 0.63 inf 325 L -3 -4 -5 -6 -2 -4 -5 -6 -5 0 6 -4 1 1 -5 -4 -1 -4 -3 0 1 0 0 0 0 0 0 0 0 1 81 0 3 5 0 0 4 0 0 5 1.11 inf 326 I -3 -5 -6 -6 -3 -5 -5 -6 -6 7 1 -5 0 -2 -5 -5 -3 -5 -3 3 0 0 0 0 0 0 0 0 0 77 6 0 1 1 0 0 0 0 0 15 1.40 inf 327 E -4 -3 -3 -1 -7 -1 7 -5 -3 -6 -6 -2 -5 -6 0 -3 -4 -6 -5 -5 0 0 0 0 0 0 96 0 0 0 0 0 0 0 4 0 0 0 0 0 2.00 inf 328 A 5 -3 -3 -4 1 -3 -3 -2 1 -2 -1 -3 -1 0 -3 0 2 3 0 -2 59 0 0 0 3 0 0 0 3 1 5 0 1 5 0 2 12 5 3 0 0.64 inf 329 M -3 -3 -4 -5 -3 -3 -4 -5 -4 1 2 -4 8 1 -5 -1 -2 -4 -2 3 0 1 0 0 0 0 0 0 0 4 13 0 49 7 0 4 0 0 1 21 1.02 inf 330 T -1 -3 -2 -3 2 0 -3 -4 -4 -3 -4 -3 -3 -4 0 1 6 -5 -4 -2 4 0 0 0 4 5 0 0 0 0 0 0 0 0 4 11 71 0 0 1 1.13 inf 331 Y -5 -1 -5 -6 -5 -4 -5 -6 -1 -4 -4 -5 -4 2 -6 -5 -5 3 9 -4 0 4 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 3 89 0 2.51 inf 332 R -4 8 -3 -4 -6 -2 -3 -5 -3 -5 -5 0 -4 -5 -5 -3 -4 -5 -4 -5 0 97 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.23 inf 333 I 0 -3 -3 -4 -2 -2 -3 -3 -2 3 1 -3 1 1 -3 -2 -1 -2 3 3 11 1 0 0 0 2 0 1 0 23 13 0 2 6 0 2 1 0 13 24 0.34 inf 334 G 0 -4 -2 -2 -4 -3 -1 6 -2 -5 -5 -3 -4 -5 -4 1 -2 -4 -4 -4 7 0 0 1 0 1 4 74 1 0 0 0 0 0 0 11 1 0 0 0 1.29 inf 335 H 2 -3 -2 -2 -4 -2 -3 1 8 -5 -5 -3 -4 -4 3 -2 -3 -5 -2 -4 20 0 0 2 0 0 0 9 49 0 0 0 0 0 18 1 0 0 0 0 1.26 inf 336 H -5 -3 -2 -4 -6 -3 -3 -5 11 -6 -6 -4 -4 -4 -5 -4 -5 -5 -1 -6 0 0 0 0 0 0 0 0 97 0 0 0 0 0 0 0 0 0 0 0 3.16 inf 337 S -1 -3 -2 -2 -3 -2 -3 -3 -3 -4 -4 -3 -4 -5 -3 6 3 -5 -4 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 75 22 0 0 0 1.29 inf 338 T -2 -3 -2 -3 -3 -3 -3 -4 -4 -3 -3 -3 2 -4 -3 1 7 -5 -4 -2 0 0 0 0 0 0 0 0 0 0 1 0 7 0 0 8 81 0 0 0 1.46 inf 339 S 2 -3 -2 -3 -3 -2 -3 -2 -3 -4 -4 -3 -4 -5 -3 6 -1 -5 -4 -4 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 81 0 0 0 0 1.32 inf 340 D -4 -4 -1 8 -6 -3 -1 -4 -4 -6 -6 -3 -5 -6 -4 -3 -4 -6 -5 -6 0 0 0 97 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.29 inf 341 D -4 -4 -1 8 -6 -3 0 -4 -2 -5 -6 -3 -5 -6 -4 -3 -4 -6 -4 -5 0 0 1 94 0 0 2 0 1 0 0 0 0 0 0 0 0 0 1 0 2.17 inf 342 S -1 -3 -3 -2 -4 -3 -3 -3 -2 -5 -5 -3 -4 -5 6 5 -2 -1 -4 -4 1 0 0 1 0 0 0 0 1 0 0 0 0 0 45 49 0 1 0 0 1.42 inf 343 S -1 -2 -1 -3 -3 -2 -2 -2 -3 -3 -3 -1 -3 2 -3 4 5 -4 -3 -2 1 2 1 0 0 0 0 2 0 0 0 2 0 9 0 44 37 0 0 1 0.77 inf 344 A 3 3 -2 -3 -3 0 -2 1 -2 -2 -2 2 -1 -3 -3 -1 -2 -2 -3 0 40 21 0 0 0 3 0 9 0 1 4 14 2 0 0 0 1 1 0 5 0.42 inf 345 Y -5 -4 -5 -6 -5 -4 -5 -6 -1 -4 -4 -5 -4 0 -6 -4 -4 -1 10 -4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 97 0 2.78 inf 346 R -4 8 -3 -4 -6 -1 -3 -5 -3 -5 -5 0 -4 -5 -5 -3 -4 -5 -4 -5 0 96 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.19 inf 347 S 1 -2 0 1 -3 -2 -1 -1 -2 -4 -4 -1 -3 -4 4 4 1 -4 -4 -3 9 1 2 10 0 1 1 3 0 0 0 1 0 0 23 39 9 0 0 0 0.67 inf 348 V 1 2 -1 0 -3 1 0 -1 -2 -1 -2 2 -1 -3 -1 0 -1 -4 -3 2 17 11 1 7 0 6 5 2 0 1 1 17 1 0 1 8 2 0 0 20 0.18 inf 349 D -1 -1 0 5 -4 0 4 -1 -2 -3 -4 -1 -3 -4 -3 -1 -1 -5 -4 -1 4 1 2 41 0 2 29 3 0 1 0 3 0 0 0 4 2 0 0 6 0.72 inf 350 E -2 -3 -3 1 -5 -1 7 -4 -3 -3 -2 -2 -3 -5 -3 -2 -3 -3 -4 -4 1 0 0 5 0 0 83 0 0 2 4 0 0 0 0 0 0 0 0 0 1.48 inf 351 V 0 -2 -1 0 -1 -2 0 -3 -2 2 0 -3 0 -1 -3 -1 -1 2 -2 4 6 2 3 6 1 0 8 1 1 10 5 0 2 1 0 5 0 3 0 45 0.31 inf 352 N 0 1 3 2 -4 1 4 -2 -2 -4 -4 0 -3 -4 -3 0 -1 -4 -3 -3 10 7 17 9 0 4 36 2 0 0 1 5 0 0 0 7 2 0 0 1 0.51 inf 353 Y 1 0 -1 1 -2 1 2 -2 4 -2 -2 1 -1 -1 -1 0 -1 -1 3 -1 13 6 2 8 0 4 14 0 12 2 2 8 1 1 2 5 2 1 13 3 0.19 inf 354 W -5 -1 -6 -6 -5 -5 -5 -5 -5 -4 -4 -5 -4 2 -6 -4 -5 12 -1 -5 1 4 0 0 0 0 0 0 0 1 1 0 0 7 0 1 0 82 0 0 3.45 inf 355 D -1 3 0 3 -4 1 1 -2 -2 -4 -3 3 -3 -4 3 -1 -1 -4 -3 -3 4 15 4 17 0 5 7 1 0 0 1 22 0 0 15 3 3 0 1 1 0.44 inf 356 K 0 2 -1 -1 -3 2 2 -3 -2 -2 1 3 -1 -3 -2 0 0 -3 -3 -2 7 10 1 1 0 8 13 0 0 1 17 27 1 0 0 5 5 0 0 2 0.25 inf 357 Q -1 2 -1 -2 -2 3 0 2 0 -2 -2 3 -1 -3 -3 -1 -1 -3 -2 -2 4 13 1 1 1 18 4 18 3 1 3 23 1 1 0 2 4 0 0 3 0.31 inf 358 D -3 1 0 6 -2 -2 0 0 -2 -3 -4 -1 -4 -1 -3 -2 -2 -4 -3 -3 1 8 3 63 1 1 3 7 1 1 1 2 0 3 0 1 2 0 1 1 0.98 inf 359 H -1 -1 3 2 1 -1 0 -1 6 -2 -2 -1 -2 -2 -1 0 -1 -2 -1 -2 3 2 19 12 3 2 3 3 25 2 4 2 1 2 2 7 4 1 1 3 0.38 inf 360 P -3 -5 -5 -5 -6 -4 -4 -5 -5 -6 -6 -4 -6 -7 9 -4 -4 -7 -6 -5 1 0 0 0 0 0 0 0 0 0 0 0 0 0 99 0 0 0 0 0 3.08 inf 361 I -3 -5 -5 -5 -3 -5 -5 -6 -5 6 3 -5 0 -2 -5 -4 -3 -4 -3 2 1 0 0 0 0 0 0 0 0 63 23 0 1 0 0 0 0 0 0 13 1.14 inf 362 S 1 -1 0 0 -2 0 1 -2 0 -1 0 0 -1 -2 1 2 1 -3 -2 0 10 3 4 5 0 2 10 1 2 3 9 4 1 0 5 21 12 0 0 9 0.12 inf 363 R -4 8 -3 -4 -6 -2 -3 -5 -3 -5 -5 1 -4 -6 -5 -4 -4 -6 -5 -5 0 95 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 2.23 inf 364 L -3 -4 -5 -6 -4 -4 -5 -5 -4 -1 4 -4 4 5 -5 -4 -3 -2 1 0 0 0 0 0 0 0 0 0 0 0 54 0 12 27 0 0 1 0 3 3 1.00 inf 365 R -3 6 -2 -3 -4 0 1 -2 -2 -5 -4 4 -3 -3 -4 -2 -3 -5 -2 -4 1 57 0 0 0 3 10 2 0 0 0 22 0 1 0 0 0 0 1 0 1.12 inf 366 H 0 3 1 -2 -4 1 -1 -3 4 -3 0 3 -2 -3 -3 -1 0 -4 -2 -2 6 18 7 0 0 6 0 0 14 0 11 25 0 0 0 2 6 0 0 2 0.38 inf 367 Y -4 -3 -4 -5 -5 -4 -4 -5 6 -4 -2 -4 -3 4 -5 -4 -4 7 7 -4 1 1 0 0 0 0 0 0 21 0 3 0 0 19 0 0 0 16 39 0 1.61 inf 368 L -4 -4 -6 -6 -2 -4 -5 -6 -5 0 6 -5 5 -2 -5 -5 -3 -4 -3 0 0 0 0 0 1 0 0 0 0 3 79 0 15 0 0 0 0 0 0 3 1.30 inf 369 L -2 0 -2 -1 -3 0 4 -4 -3 2 1 0 2 -2 -3 -2 0 -4 -3 1 1 5 0 1 0 3 32 0 0 19 14 5 5 1 0 0 5 0 0 9 0.32 inf 370 S 1 1 2 1 -3 0 0 0 0 -3 -3 2 -3 -3 -2 2 -1 -4 -2 -3 11 10 14 8 0 3 4 7 2 0 2 13 0 0 0 22 2 0 0 1 0.29 inf 371 Q -2 4 0 -2 -4 3 0 -4 0 -1 -1 4 -1 -3 -3 -2 -1 -4 -3 -3 0 24 4 0 0 17 4 0 2 4 8 31 1 0 0 1 3 0 0 0 0.55 inf 372 G -2 -3 0 -1 -5 -2 -2 7 -4 -6 -6 0 -5 -5 -4 -2 -3 -5 -5 -5 1 1 4 3 0 1 2 81 0 0 0 5 0 0 0 1 0 0 0 0 1.50 inf 373 W -1 -2 -5 -3 -1 -2 -1 -4 -1 1 3 -3 0 -1 -5 -4 -4 10 -1 -1 6 2 0 1 1 1 6 0 1 8 28 1 1 0 0 0 0 39 1 3 1.24 inf 374 W -6 -6 -7 -8 -5 -5 -6 -6 -6 -3 1 -6 -3 1 -7 -6 -5 12 0 -5 0 0 0 0 0 0 0 0 0 2 12 0 0 4 0 0 1 80 2 0 3.43 inf 375 D -1 -3 3 5 -1 -2 -1 0 -3 -4 -5 -2 -4 -5 -3 4 1 -5 -4 -4 3 0 14 35 1 0 0 5 0 0 0 0 0 0 0 33 9 0 0 0 0.79 inf 376 E -2 -2 -1 4 -5 0 6 -3 -3 -5 -4 -1 -3 -5 -1 -2 -3 -5 -4 -4 3 1 1 19 0 3 63 1 0 0 1 2 0 0 3 1 0 0 0 1 1.11 inf 377 E 1 -2 -1 2 -5 1 6 -2 -2 -5 -5 1 -3 -5 -3 -1 -2 -5 -4 -3 14 0 2 13 0 4 55 2 0 0 0 6 0 0 0 1 1 0 0 1 0.87 inf 378 Q -1 3 -2 1 -4 4 3 -3 0 -4 -3 2 -1 -4 -3 -1 -1 2 -3 -3 6 15 0 6 0 21 27 0 1 0 2 12 2 0 0 1 2 4 0 1 0.54 inf 379 E -1 -2 -1 3 -5 0 6 -4 5 -4 -5 -2 -4 -4 -3 -1 -2 -5 -3 -1 3 0 1 14 0 2 57 0 14 1 0 0 0 1 0 2 1 0 0 5 1.02 inf 380 K 1 1 1 0 -4 2 2 -2 -2 -2 -3 3 -2 -4 -2 0 0 -4 -3 -2 14 6 8 4 0 7 16 1 0 2 1 29 1 0 1 6 4 0 0 1 0.36 inf 381 A 3 -1 -1 0 -3 2 3 -2 -1 -3 -3 1 -3 -4 -3 0 1 -4 -3 -2 33 1 1 5 0 9 26 0 1 1 2 8 0 0 0 5 7 0 0 1 0.44 inf 382 W 1 -2 -4 -4 -2 -1 -2 -3 -1 1 3 -3 1 0 -4 -2 0 7 -1 1 13 2 0 0 1 2 1 1 2 8 30 1 4 3 0 1 5 16 1 11 0.44 inf 383 R -1 4 -2 -1 -4 2 1 -3 -1 1 -1 1 -1 -3 -3 -1 -1 -1 -1 0 3 35 0 3 0 10 11 1 1 9 3 8 1 0 0 1 2 1 2 8 0.38 inf 384 K 2 0 -1 2 -4 0 3 -2 -2 -4 -3 4 -2 -4 -3 0 -1 -5 -4 -3 21 4 2 10 0 2 22 1 0 0 1 29 0 0 0 5 3 0 0 0 0.49 inf 385 Q -1 1 1 1 -4 4 4 -3 -1 -4 -4 2 -3 -5 -3 1 -1 -4 -3 -4 4 6 5 6 0 25 30 1 1 0 0 10 0 0 0 10 4 0 0 0 0.62 inf 386 S 2 -3 -2 -3 -1 -2 -1 -3 -2 2 1 -2 0 1 -3 1 0 -1 1 2 19 0 1 0 1 0 3 0 1 14 16 0 2 5 0 13 4 1 5 15 0.17 inf 387 R -1 6 0 -1 -5 1 0 -3 -2 -4 -2 3 -1 -5 -4 -2 -1 -5 -4 -3 4 48 3 4 0 5 6 0 0 0 3 21 2 0 0 1 3 0 0 1 0.80 inf 388 R 1 1 0 2 -4 2 3 -2 -2 -4 -4 4 -2 -5 -3 -1 -1 -4 -3 -3 16 8 3 9 0 7 20 1 0 1 0 31 0 0 0 3 2 0 0 0 0.51 inf 389 K -1 0 -1 2 -4 2 4 -3 -2 -3 -1 1 -2 -3 -3 -1 0 -4 -2 -3 5 3 1 12 0 10 40 1 0 1 7 10 1 1 0 2 5 0 1 1 0.50 inf 390 V -2 -5 -5 -6 -3 -5 -5 -6 -5 4 0 -5 2 -3 -5 -4 -2 -5 -3 6 0 0 0 0 0 0 0 0 0 22 5 0 5 0 0 0 1 0 0 67 1.21 inf 391 M 0 0 -2 -1 -3 -2 -1 -3 -2 1 3 1 4 -2 -4 -2 -1 -4 -3 -1 7 5 1 4 0 1 4 0 1 8 39 10 15 0 0 2 2 0 0 2 0.34 inf 392 E 3 1 -1 1 -4 2 3 -3 -1 -3 -4 2 -3 -4 -3 0 0 -4 -3 -3 26 6 1 7 0 12 22 0 1 1 0 17 0 0 0 3 4 0 0 0 0.47 inf 393 A 5 -3 -3 -3 -1 -1 1 -2 -3 -3 -3 -1 -1 -4 -3 1 0 -5 -4 -1 68 0 0 0 1 2 8 1 0 0 1 2 1 0 0 7 4 0 0 3 0.84 inf 394 F -3 -3 -4 -5 -3 1 -4 -4 -3 3 2 -4 2 5 -4 -3 -2 -1 0 1 1 0 0 0 0 8 0 0 0 20 22 0 6 27 0 0 1 0 2 11 0.57 inf 395 E 1 1 -1 -1 -4 1 3 -1 -1 -3 -3 4 -2 -4 -3 0 0 -4 -3 -2 10 6 2 2 0 6 18 3 1 0 1 38 0 0 0 5 5 0 0 2 0.49 inf 396 Q 2 2 -1 0 -3 2 4 -3 -1 -2 -3 1 -3 -4 -3 -1 -1 -4 -2 0 17 10 1 2 0 12 30 1 1 1 1 10 0 0 0 1 3 0 1 8 0.40 inf 397 A 6 -4 -4 -4 -2 -1 -3 -1 -2 -3 -3 -3 0 -4 -3 0 -2 -5 -1 0 76 0 0 0 0 3 0 2 1 0 1 0 3 0 0 6 0 0 2 6 1.08 inf 398 E -3 -3 -2 1 -6 0 7 -4 -3 -5 -5 -2 -5 -6 -4 -2 -4 -6 -5 -4 2 0 0 7 0 2 86 0 0 0 1 1 0 0 0 1 0 0 0 1 1.76 inf 399 R 2 3 0 -2 -4 1 0 -2 -2 -4 -3 4 -2 -4 -3 1 -1 -5 -3 -3 18 20 3 1 0 4 5 2 0 0 1 34 0 0 0 9 2 0 0 1 0.55 inf 400 K -1 0 -1 -1 -3 0 1 -3 1 0 1 2 1 -1 -3 -1 0 -1 1 1 5 3 3 1 0 2 10 0 5 7 13 20 4 2 0 2 7 1 6 9 0.09 inf 401 P -2 -2 -3 -2 -4 -1 1 2 -3 -4 0 2 -3 -4 6 -1 -3 -5 -4 -4 2 1 0 1 0 2 9 15 0 0 11 17 0 1 39 2 0 0 0 0 0.79 inf 402 K -1 2 -2 -2 -5 -1 -1 -4 2 -3 -2 6 -2 -5 1 -1 -1 -5 -4 -3 3 11 0 1 0 1 1 0 5 1 3 59 1 0 6 2 4 0 0 1 0.88 inf 403 P -1 -4 -4 -4 -1 1 -3 -3 1 -5 -4 -3 -4 -5 7 -1 -3 2 -2 -2 6 0 0 0 2 8 0 2 3 0 1 0 0 0 67 3 1 3 1 3 1.65 inf 404 N 0 -1 3 1 -3 -1 0 -1 1 -4 -4 1 -2 -4 4 2 -1 -5 -3 -3 9 1 19 7 0 1 3 3 3 0 0 8 1 0 25 16 2 0 0 1 0.55 inf 405 P -1 -3 -4 -4 -3 -3 -4 -5 -4 2 2 -3 1 -1 4 -3 -2 3 -2 3 4 1 0 0 0 0 0 0 0 12 27 0 3 2 19 0 1 5 1 25 0.57 inf 406 N 0 2 2 1 -3 1 2 0 0 -3 -3 1 -2 -4 -2 1 1 -4 -3 -2 10 11 12 8 0 5 18 5 2 1 1 8 0 0 1 9 8 0 0 2 0.27 inf 407 L -1 -2 0 3 -2 0 3 -1 0 -3 0 -2 -2 -3 -3 1 1 -1 -2 -2 3 0 3 19 0 1 25 4 2 0 12 0 1 1 0 14 11 1 1 1 0.32 inf 408 L -2 -4 -5 -6 -2 -4 -5 -6 -5 2 4 -4 7 -2 -5 -4 -3 -4 -3 0 3 0 0 0 0 0 0 0 0 13 45 0 36 1 0 0 0 0 0 2 1.17 inf 409 F -5 -6 -6 -6 -2 -6 -6 -6 -1 1 -1 -6 1 8 -6 -5 -5 0 0 -1 0 0 0 0 1 0 0 0 2 8 2 0 4 80 0 0 0 1 1 2 1.95 inf 410 S -1 0 0 3 -4 0 4 -3 -2 -4 -4 0 -3 -5 -3 2 2 -5 -3 -3 4 3 4 17 0 2 32 1 0 0 1 4 0 0 0 19 12 0 0 0 0.56 inf 411 D -4 -4 0 7 -4 -3 -1 0 2 -2 -5 -3 -5 -3 -4 -3 -4 -5 1 -4 0 0 4 71 0 0 1 7 5 4 0 0 0 1 0 0 0 0 6 0 1.43 inf 412 V -3 -5 -6 -6 -2 -5 -5 -6 -2 0 -1 -5 3 -3 -5 -4 -2 -6 -4 7 1 0 0 0 1 0 0 0 1 1 1 0 8 0 0 0 1 0 0 87 1.58 inf 413 Y -5 -5 -5 -6 -6 -5 -5 -6 -1 -4 -4 -5 -4 4 -6 -5 -5 1 9 -4 0 0 0 0 0 0 0 0 0 0 0 0 0 14 0 0 0 1 84 0 2.59 inf 414 Q 2 0 -1 3 -4 2 3 -2 1 -4 -4 2 -3 -3 -3 -1 -2 -4 -2 -3 21 5 0 19 0 7 21 2 4 0 0 15 0 1 0 2 0 0 1 0 0.47 inf 415 E -2 -2 -1 2 -5 1 5 -3 -1 -3 -4 1 -3 -4 -3 -2 1 -5 -3 -1 2 0 2 13 0 4 54 1 1 1 0 7 0 0 0 1 8 0 0 4 0.82 inf 416 M -3 -3 -4 -4 -4 -2 0 -5 -4 0 1 -1 7 -3 4 -3 -2 -4 -4 0 1 1 0 0 0 1 6 0 0 4 14 4 42 0 21 0 2 0 0 6 0.95 inf 417 P -3 -4 -3 0 -5 -3 -4 -5 -2 -3 -1 -4 -4 -5 7 -2 3 -6 -5 -4 0 0 0 5 0 0 0 0 1 2 6 0 0 0 61 2 23 0 0 0 1.61 inf 418 A 1 -1 -2 -2 -4 1 1 -3 -3 -4 -3 0 -4 -2 5 -1 -2 7 -1 -3 15 2 1 2 0 6 8 0 0 0 2 4 0 1 32 5 1 19 1 1 0.92 inf 419 Q -2 2 3 0 -5 2 1 -3 7 -3 -2 -2 -2 -3 -3 -2 -1 -5 -2 -3 2 10 18 5 0 10 7 0 35 1 3 0 1 1 0 1 3 0 0 1 0.78 inf 420 L -3 -5 -6 -6 -4 -1 -5 -6 -5 2 6 -5 0 -2 -5 -5 -3 -4 -4 0 2 0 0 0 0 3 0 0 0 10 82 0 1 0 0 0 0 0 0 2 1.26 inf 421 R -1 4 -2 -2 -2 4 1 -4 0 -1 -1 3 -1 -3 -3 -2 -1 -2 -3 -1 5 25 1 1 1 20 8 0 2 4 5 19 1 0 0 1 2 0 0 5 0.45 inf 422 K 0 3 -2 -1 -5 2 5 -4 -2 -5 -5 3 -3 -5 -3 -1 -3 -5 -4 -4 6 17 1 2 0 6 47 0 0 0 0 19 0 0 0 2 0 0 0 0 0.93 inf 423 Q -3 -2 -3 -4 -6 9 -1 -5 -2 -6 -6 -2 -4 -7 -5 -3 -4 -6 -5 -6 2 0 0 0 0 97 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2.57 inf 424 Q -2 4 -2 -3 -3 3 1 -4 -2 -2 0 1 4 -1 -4 -2 -3 -2 2 -2 1 28 0 0 0 17 8 0 0 1 11 9 13 2 0 1 0 0 8 1 0.53 inf 425 E 0 1 0 3 -4 3 4 -3 0 -4 -3 2 -3 -5 -3 -1 -1 -5 -4 -3 10 7 3 15 0 14 32 1 1 0 1 11 0 0 0 1 2 0 0 0 0.56 inf 426 S 0 -2 -1 0 -3 3 5 -1 -2 -1 -2 -1 -2 -3 -3 1 -2 0 -1 -3 8 1 1 2 0 15 41 4 0 5 4 1 1 0 0 10 0 1 2 1 0.51 inf 427 L -2 -4 -5 -5 -1 -4 -5 -5 -4 0 5 -4 4 2 -5 -3 -2 -1 3 1 2 0 0 0 1 0 0 0 0 2 56 0 11 7 0 1 1 0 12 7 0.80 inf 428 A 1 2 -1 -1 -3 0 2 -2 0 -1 0 3 0 -2 -3 -1 -2 -1 -2 -1 14 11 1 2 0 3 16 1 2 3 12 26 2 2 0 1 0 1 0 2 0.25 inf 429 R 1 4 -1 2 -4 2 3 -3 -1 -4 -4 1 -3 -5 -3 1 -2 -4 -3 -4 15 26 0 11 0 8 24 1 1 0 0 5 0 0 0 9 1 0 0 0 0.55 inf 430 H -3 -2 -2 -3 -4 -1 0 -4 8 1 0 -3 -1 1 -4 -2 -1 2 1 -1 1 2 0 0 0 2 7 0 50 8 8 0 1 5 0 2 5 3 4 3 0.99 inf 431 L -3 1 -4 -4 -3 -2 -3 -5 -3 3 4 -1 2 1 -3 -3 -2 1 0 1 0 10 0 0 0 1 1 0 0 18 44 3 5 4 1 0 0 2 3 9 0.48 inf 432 Q 0 2 0 0 -4 3 4 -2 -1 -4 -3 4 -1 -4 -3 -1 -1 -4 -3 -4 6 11 3 5 0 13 27 2 0 0 1 27 1 0 0 2 2 0 0 0 0.56 inf 433 T 0 3 -1 -2 -4 1 2 -3 -1 -3 -2 4 -2 -4 -3 -1 2 -4 -3 -3 10 19 1 1 0 4 12 0 1 0 3 30 0 0 0 1 19 0 0 1 0.49 inf 434 Y -2 -2 0 -4 -5 -2 -3 -5 6 -4 -4 -2 -3 2 -2 -2 -4 3 8 -4 2 1 6 0 0 0 1 0 19 0 0 3 0 5 2 2 0 3 56 0 1.42 inf 435 G -2 -1 -3 -3 -5 -2 -2 5 -2 -5 -5 2 -4 -5 5 -1 -3 -5 -5 -5 2 3 0 0 0 1 1 42 1 0 0 13 0 0 35 2 1 0 0 0 1.11 inf 436 E -2 -1 0 4 -5 2 5 -1 0 -5 -5 1 -4 -5 -2 0 -2 -5 -4 -4 2 2 4 25 0 7 42 3 1 0 0 8 0 0 1 4 0 0 0 0 0.76 inf 437 H 1 -1 0 2 -2 0 3 -2 6 -3 -4 -1 -2 -1 -2 -1 -2 -4 0 -2 11 1 3 12 1 2 23 1 30 1 0 2 0 2 1 2 1 0 3 3 0.57 inf 438 Y -1 -3 -5 -5 -2 -4 -3 -5 -1 -4 -2 -4 -3 1 -5 -4 -3 4 9 -2 6 1 0 0 1 0 2 0 0 0 2 0 0 1 0 0 1 5 80 2 1.94 inf 439 P -3 -4 0 3 -5 -3 -2 -4 -4 -4 -1 -2 -4 -3 7 -3 -3 -6 -5 -4 0 0 4 19 0 0 1 0 0 0 8 2 0 1 64 0 1 0 0 0 1.58 inf 440 L -1 -3 -4 -4 -1 -1 -3 -4 -4 1 4 -2 2 -1 -2 -1 1 -3 -2 1 2 0 0 0 1 3 1 1 0 6 57 1 4 1 1 3 8 0 0 11 0.46 inf 441 D -2 -1 2 5 -4 0 3 -1 0 -4 -4 1 -3 -4 -3 1 -1 -4 -2 -4 1 2 8 35 0 1 24 4 1 0 0 9 0 0 0 11 1 0 1 0 0.59 inf 442 H -1 0 0 2 -4 3 2 -1 5 -3 -2 1 -2 -3 -1 0 -1 -4 -2 -2 2 3 3 11 0 15 18 3 19 0 5 12 0 0 2 6 0 0 0 1 0.37 inf 443 F -4 -4 -4 -5 -4 -3 -4 -5 5 -2 -1 -4 -2 7 -5 -4 -4 -1 5 -3 0 0 0 0 0 0 0 0 17 0 2 0 0 60 0 0 0 0 21 0 1.38 inf 444 D -1 -1 -1 3 -4 1 5 -3 -2 -3 -2 2 -3 -4 -2 -1 -2 -4 -3 -3 3 0 0 16 0 5 57 0 0 0 6 11 0 0 0 0 1 0 0 1 0.70 inf 445 K -2 3 -1 -1 -4 4 1 -3 -1 -4 -3 5 -2 -4 -2 -1 -1 -3 -2 -3 0 19 0 0 0 28 2 0 0 0 0 51 0 0 0 0 0 0 0 0 0.71 inf K Lambda Standard Ungapped 0.1346 0.3196 Standard Gapped 0.0410 0.2670 PSI Ungapped 0.1713 0.3175 PSI Gapped 0.0524 0.2670 CLUSTAL 2.0.12 multiple sequence alignment gi|39943658|ref|XP_361366.1| ----MR--VRLPGAASSIGR---RCRNHGR-------------------- gi|164422564|ref|XP_960181.2| ----MKRICRSSQRSPSLLRPLTPVTHQPR-------------------- gi|21355903|ref|NP_649905.1| ---------------MSFLRKSVHLLGS---------------------- gi|158291301|ref|XP_312823.4| -------------------------LSS---------------------- gi|11386135|ref|NP_000700.1| --------MAVAIAAARVWRL-NRGLSQ---------------------- gi|148727347|ref|NP_001092034. --------MAVAIAAARVWRL-NRGLSQ---------------------- gi|297277135|ref|XP_001101959. --------MAVAIAAARVWRP-NRGLSQ---------------------- gi|73947481|ref|XP_866392.1| --------MAVAAAAARVWGS-SRGLGQ---------------------- gi|27806229|ref|NP_776931.1| MQGSAKMAMAVAVAVARVWRP-SRGLGR---------------------- gi|183396774|ref|NP_031559.3| --------MAIVMSAAKIWRP-SRGLRQ---------------------- gi|77736548|ref|NP_036914.1| --------MAVAMSAAKIWRP-SRGLRQ---------------------- gi|66773104|ref|NP_001019590.1 --------MAAARAVKKLYGIGLHAIRQN--------------------- gi|86563355|ref|NP_001033376.1 -------------------------MHR---------------------- gi|18415939|ref|NP_568209.1| ----MALHLRSSFSSKSTLLNILRHNLGFGSRSHVTR--------HIRQI gi|115487674|ref|NP_001066324. ----MAPWRAAAMASSQLARRAARRLLSSQHRRHCAAPACPWLLGSAPPV gi|39943658|ref|XP_361366.1| --------GAP-KIGSLHQTAPGSASSMRAASTLKQKP-----DSSFVSF gi|164422564|ref|XP_960181.2| --------LVPIAIQPSTTTTSKTVASRRHASSLSQRP-----DASHVMF gi|21355903|ref|NP_649905.1| ------------VARRQRHLKVIEGAISTAARDFSSKP-----SEDYANF gi|158291301|ref|XP_312823.4| ------------DAASQ--------------QQGASGP-----SSLHAKF gi|11386135|ref|NP_000700.1| --------AALLLLRQPGARGLARSHPPR--QQQQFSS-----LDDKPQF gi|148727347|ref|NP_001092034. --------AALLLLRRPGARGLARSHPRR--QQQQFSS-----LDDKPQF gi|297277135|ref|XP_001101959. --------AALLLLWRPGARGLARSHPHR--QQQQFSS-----LDDKPQF gi|73947481|ref|XP_866392.1| --------AGLLLLRRPWARGLARSHPQR-QEQQHFPS-----LDDKPQF gi|27806229|ref|NP_776931.1| --------TGLPLLRLLGARGLARFHPHRWQQQQHFSS-----LDDKPQF gi|183396774|ref|NP_031559.3| --------AALLLLGRSGVRGLARSHPSR-QQQQQFPS-----LDDKPQF gi|77736548|ref|NP_036914.1| --------AALLLLGRPGARGLARFHPSR-QQQQQFPS-----LDDKPQF gi|66773104|ref|NP_001019590.1 --------TALKATTLLQQRGFRVNGVLR---QQSIDD-----SDEKPQF gi|86563355|ref|NP_001033376.1 --------ALLNASRRVATVRSMASTVEG----DAFRL-----SEYSSKY gi|18415939|ref|NP_568209.1| LPHDPPLRGSQNPISRLCNT---MAEPETLSSFVQHEY---ANNHQVMDF gi|115487674|ref|NP_001066324. LAPSPVAAAAAGDRRGFCSVRRFTGESNAAAAVEEAENGLVAGGDQAIDF : gi|39943658|ref|XP_361366.1| PGAVKSEFTTKFQFERPEQYPAMPTYRVVDQHGVVVDPEFEQDLNDEGVI gi|164422564|ref|XP_960181.2| PGAVKSAFCNTMTFEEPSKYDALPTYRAVDQHGQVVDPSFKPDLSDKEVI gi|21355903|ref|NP_649905.1| PGA-KAPFVSKLNLIQPEDYAPIPIYRVMDQDGYIADETQDPQLGREVVE gi|158291301|ref|XP_312823.4| PGALEASFVTTPKLALPESIEPIPIYRVMNSEGVIDDPSQEPNLEQATVQ gi|11386135|ref|NP_000700.1| PG-ASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVL gi|148727347|ref|NP_001092034. PG-ASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVL gi|297277135|ref|XP_001101959. PG-ASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVL gi|73947481|ref|XP_866392.1| PG-ASAEFIDKLEFIQPNVISGIPVYRVMDRQGQIINPSEDPHLPQEKVL gi|27806229|ref|NP_776931.1| PG-ASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEKVL gi|183396774|ref|NP_031559.3| PG-ASAEFVDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEEVL gi|77736548|ref|NP_036914.1| PG-ASAEFVDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEEVL gi|66773104|ref|NP_001019590.1 PG-ASAEFIDHLEFIQPNVISGIPVYRVMDRQGQIINPSEDPQLSKETVL gi|86563355|ref|NP_001033376.1 LGHRKAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSL gi|18415939|ref|NP_568209.1| PG-GKVAFTPEIQFISESDKERVPCYRVLDDNGQLITNSQFVQVSEEVAV gi|115487674|ref|NP_001066324. PG-GKVSFVAEMNFLPESQRDRINCYRVLDDDGRTISGSRFQEVSKELAL * . * : . : **. : * .. gi|39943658|ref|XP_361366.1| KLYEDMVAVSVMDSIMFDAQRQGRVSFYMVSAGEEAVCVGSASALEMRDV gi|164422564|ref|XP_960181.2| KLYHDMLTVSIMDLIMFDAQRQGRLSFYMVSAGEEAVCVGSASALSPEDV gi|21355903|ref|NP_649905.1| KMFRDMVLLNTMDKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDL gi|158291301|ref|XP_312823.4| KMFRDMVLLNTMDKILYESQRQGRISFYMTNFGEEASHIGSAAALSLEDW gi|11386135|ref|NP_000700.1| KLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDL gi|148727347|ref|NP_001092034. KLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDL gi|297277135|ref|XP_001101959. KLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDL gi|73947481|ref|XP_866392.1| KFYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDL gi|27806229|ref|NP_776931.1| KFYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDDTDL gi|183396774|ref|NP_031559.3| KFYRSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALERTDL gi|77736548|ref|NP_036914.1| KLYRSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALERTDL gi|66773104|ref|NP_001019590.1 NFYQKMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHIGSAAALDPSDL gi|86563355|ref|NP_001033376.1 KMYKTMTQLNIMDRILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDL gi|18415939|ref|NP_568209.1| KIYSDMVTLQIMDNIFYEAQRQGRLSFYATAIGEEAINIASAAALTPQDV gi|115487674|ref|NP_001066324. KMYNEMATLQVMDTIFFEAQRQGRISFYLTSHGEEAINIASAAALTIDDI ::: * :. ** *::::*****:*** . ***. :.**:** * gi|39943658|ref|XP_361366.1| IFCQYREQGVYRHRGMTFRDFMNQLFANKYDPGQGRNMPVHYGSKELNMH gi|164422564|ref|XP_960181.2| VFCQYREQGVFKQRGFQLSDFMNQLFANHKDSGKGRNMPVHYGSKELNIH gi|21355903|ref|NP_649905.1| IYGQYREAGVLVWRGFRIDQFIDQCYGNTDDLGRGKQMPVHYGSRELNFV gi|158291301|ref|XP_312823.4| VYGQYREAGVLVWRGFTISDFINQCYGNAEDQGKGRQMPVHYGSRKLNFV gi|11386135|ref|NP_000700.1| VFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFV gi|148727347|ref|NP_001092034. VFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFV gi|297277135|ref|XP_001101959. VFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFV gi|73947481|ref|XP_866392.1| VFGQYREAGVLMYRDYPLELFMAQCYGNVSDPGKGRQMPVHYGCKDRHFV gi|27806229|ref|NP_776931.1| VFGQYREAGVLMYRDYPLELFMAQCYGNVSDLGKGRQMPVHYGCRERHFV gi|183396774|ref|NP_031559.3| VFGQYREAGVLMYRDYPLELFMSQCYGNVNDPGKGRQMPVHYGCKERHFV gi|77736548|ref|NP_036914.1| VFGQYREAGVLMYRDYPLELFMAQCYGNVSDPGKGRQMPVHYGCKERHFV gi|66773104|ref|NP_001019590.1 VFGQYREAGVLMYRGFPLDLFMAQCYANADDLGKGRQMPVHYGSKDLNFV gi|86563355|ref|NP_001033376.1 IYGQYREAGVLLWRGYTMENFMNQCYGNADDLGKGRQMPMHFGTKERNFV gi|18415939|ref|NP_568209.1| IFPQYREPGVLLWRGFTLQEFANQCFGNKSDYGKGRQMPVHYGSNKLNYF gi|115487674|ref|NP_001066324. VLPQYREPGVLLWRGFTLQEFANQCFGNKLDYGKGRQMPIHYGSNRLNYF : **** ** *. : * * :.* * *:*::**:*:* . : gi|39943658|ref|XP_361366.1| TISSPLATQIPQASGAAYAMKMQRIANPDAPERVAVVYFGEGAASEGDFH gi|164422564|ref|XP_960181.2| TISSPLATQLPQAAGAAYALKIQRMQNPTVPPRVVAAYFGEGAASEGDFH gi|21355903|ref|NP_649905.1| TISSPLSTQMPQAVGAAYAMKLRPNND-----ACVVCYFGEGAASEGDAH gi|158291301|ref|XP_312823.4| TISSPLGTQIPQAAGAAYAFKLQPNNQ-----RCVITYFGEGAASEGDTH gi|11386135|ref|NP_000700.1| TISSPLATQIPQAVGAAYAAKRA-NAN-----RVVICYFGEGAASEGDAH gi|148727347|ref|NP_001092034. TISSPLATQIPQAVGAAYAAKRA-NAN-----RVVICYFGEGAASEGDAH gi|297277135|ref|XP_001101959. TISSPLATQIPQAVGAAYAAKRA-NAN-----RVVICYFGEGAASEGDAH gi|73947481|ref|XP_866392.1| TISSPLATQIPQAVGAAYAAKRA-NAN-----RVVICYFGEGAASEGDAH gi|27806229|ref|NP_776931.1| TISSPLATQIPQAVGAAYAAKRA-NAN-----RVVICYFGEGAASEGDAH gi|183396774|ref|NP_031559.3| TISSPLATQIPQAVGAAYAAKRA-NAN-----RIVICYFGEGAASEGDAH gi|77736548|ref|NP_036914.1| TISSPLATQIPQAVGAAYAAKRA-NAN-----QIVICYFGEGAASEGDAH gi|66773104|ref|NP_001019590.1 TISSPLATQIPQAAGAAYAVKRE-NAN-----RVVICYFGEGAASEGDAH gi|86563355|ref|NP_001033376.1 TISSPLTTQLPQAVGSAYAFKQQKDNN-----RIAVVYFGDGAASEGDAH gi|18415939|ref|NP_568209.1| TVSATIATQLPNAVGAAYSLKMD-KKD-----ACAVTYFGDGGTSEGDFH gi|115487674|ref|NP_001066324. TVSSPIATQLPHAVGAAYSLKMD-KKD-----ACAITYFGDGGTSEGDFH *:*:.: **:*:* *:**: * : . ***:*.:**** * gi|39943658|ref|XP_361366.1| AALNIAATRACPVIFICRNNGYSISTPSLEQYKGDGIASR-GVGYGIDTV gi|164422564|ref|XP_960181.2| AALNIAATRGCPAVFICRNNGYAISTPTLEQYRGDGIASR-GLGYGIETI gi|21355903|ref|NP_649905.1| AAFNFAATLGCPAILFCRNNGFAISTPSHEQYKGDGIAGRGPMGYGITTI gi|158291301|ref|XP_312823.4| AAFNFAATLDSPVIFFCRNNGFAISTPSKEQYRGDGIAGR-AAGYGMAAL gi|11386135|ref|NP_000700.1| AGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAAR-GPGYGIMSI gi|148727347|ref|NP_001092034. AGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAAR-GPGYGIMSI gi|297277135|ref|XP_001101959. AGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAR--GPGYGIMSI gi|73947481|ref|XP_866392.1| AGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAAR-GPGYGIMSI gi|27806229|ref|NP_776931.1| AGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAAR-GPGYGILSI gi|183396774|ref|NP_031559.3| AGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAAR-GPGYGIMSI gi|77736548|ref|NP_036914.1| AGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAAR-GPGYGIMSI gi|66773104|ref|NP_001019590.1 AGFNFSATLECPLIFFCRNNGYAISTPTNEQYRGDGIAAR-GPGYGLMSI gi|86563355|ref|NP_001033376.1 AAFNFAATLKCPIIFFCRNNGYAISTPTSEQYGGDGIAGK-GPAYGLHTI gi|18415939|ref|NP_568209.1| AALNIAAVMEAPVLFICRNNGWAISTPTSDQFRSDGVVVK-GRAYGIRSI gi|115487674|ref|NP_001066324. AALNFAAVMEAPVIFFCRNNGWAISTPTSEQFRSDGAVIR-GQAYGMRSI *.:*::*. .* :::*****::****: :*: .** . .**: :: gi|39943658|ref|XP_361366.1| RVDGNDIWAVRKATKKARELALENGGKPVLLECLTYRVGHHSTSDDSFAY gi|164422564|ref|XP_960181.2| RVDGNDFWAVREVTKRARELALQDGGKPVLIEAMTYRVSHHSTSDDSFAY gi|21355903|ref|NP_649905.1| RVDGTDVFAVYNAMKAAREYVLKE-NKPVVFEALAYRVGHHSTSDDSTAY gi|158291301|ref|XP_312823.4| RFDGTDVFATYNATKLAREYVLRE-NKPIVLEAMAYRIGHHSTSDDSTAY gi|11386135|ref|NP_000700.1| RVDGNDVFAVYNATKEARRRAVAE-NQPFLIEAMTYRIGHHSTSDDSSAY gi|148727347|ref|NP_001092034. RVDGNDVFAVYNATKEARRRAVAE-NQPFLIEAMTYRIGHHSTSDDSSAY gi|297277135|ref|XP_001101959. RVDGNDVFAVYNATKEARRRAVAE-NQPFLIEAMTYRIGHHSTSDDSSAY gi|73947481|ref|XP_866392.1| RVDGNDVFAVYNATKEARRRAVAE-NQPFLIEAMTYRIGHHSTSDDSSAY gi|27806229|ref|NP_776931.1| RVDGNDVFAVYNATKEARRRAVAE-NQPFLIEAMTYRIGHHSTSDDSSAY gi|183396774|ref|NP_031559.3| RVDGNDVFAVYNATKEARRRAVAE-NQPFLIEAMTYRIGHHSTSDDSSAY gi|77736548|ref|NP_036914.1| RVDGNDVFAVYNATKEARRRAVAE-NQPFLIEAMTYRIGHHSTSDDSSAY gi|66773104|ref|NP_001019590.1 RVDGNDVFAVYNATKEARRRAVAE-NQPFLIEAMTYRIGHHSTSDDSSAY gi|86563355|ref|NP_001033376.1 RVDGNDLLAVYNATKEARRVALT--NRPVLIEAMTYRLGHHSTSDDSTAY gi|18415939|ref|NP_568209.1| RVDGNDALAMYSAVHTAREMAIRE-QRPILIEALTYRVGHHSTSDDSTRY gi|115487674|ref|NP_001066324. RVDGNDALAVYSAVHTAREMAIKE-GRPILVEALTYRVGHHSTSDDSTKY *.**.* * .. : **. .: :*.:.*.::**:.******** * gi|39943658|ref|XP_361366.1| RARVEVEDWKRRDNPISRLRKWMESKDMWDDDKEKVMRDRLRKEILKAFS gi|164422564|ref|XP_960181.2| RAKVEVEDWKRRDNPIGRLRKWMEAKGIWDENMEREARDSIRRDILKAFS gi|21355903|ref|NP_649905.1| RPAEEIEIWNSVEHPISKLKRYMVHKGWFDETVENEYVKDIRKKVLKQIA gi|158291301|ref|XP_312823.4| RPAEELEVWNTVEHPIAKLKHYMLRRGWFDEAKENEFVKSVRKQVLSQIN gi|11386135|ref|NP_000700.1| RSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFE gi|148727347|ref|NP_001092034. RSVDEVNYWDKQDHPVSRLRHYLLSQGWWDEEQEKAWRKQSRKKVMEAFE gi|297277135|ref|XP_001101959. RSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRKKVMEAFE gi|73947481|ref|XP_866392.1| RSVDEVNYWDKQDHPISRLRHYLQSRGWWDDEQEKAWRKQSRKKVMEAFE gi|27806229|ref|NP_776931.1| RSVDEVNYWDKQDHPISRLRHHLQSRGWWDDEQEKAWRKQSRKKVMEAFE gi|183396774|ref|NP_031559.3| RSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEKAWRKQSRKKVMEAFE gi|77736548|ref|NP_036914.1| RSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEKAWRKQSRKKVMEAFE gi|66773104|ref|NP_001019590.1 RSVDEVNYWDKQDHPISRLRHYMTARDWWGEDEERAWRKQSRKLVMEAFE gi|86563355|ref|NP_001033376.1 RSSDEVQTWGDKDHPITRFKKYITERGWWNEEKEMEWQKEVKKRVLTEFA gi|18415939|ref|NP_568209.1| RSAGEIEWWNKARNPLSRFRTWIESNGWWSDKTESDLRSRIKKEMLEALR gi|115487674|ref|NP_001066324. RPVDEIEHWRTARDPISRYRKWVQGNGWWCDEDESELRNNVRQELLKAIQ *. *:: * .*: : : : .. : : * . :: :: : gi|39943658|ref|XP_361366.1| EAEKEKKPPIRAMFEDVYEEMTPDLKKQMAELKDHIERYPEEYD-VGEFE gi|164422564|ref|XP_960181.2| QAEKEKKPAIRTMFEDVYEEMTPEIKAQMKELKEHLEQYPEEYD-LGDFE gi|21355903|ref|NP_649905.1| VSEKKLKPNWREMFEGVYAEMPDHLIEQRSELEKHIEAHKEHYP-LKDFE gi|158291301|ref|XP_312823.4| QSERILKPDWREMFQDVYAEMPAHLKEQLRAMEEHVEQHREHYP-LKDFK gi|11386135|ref|NP_000700.1| QAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYP-LDHFD gi|148727347|ref|NP_001092034. QAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYP-LDHFD gi|297277135|ref|XP_001101959. QAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYP-LEHFD gi|73947481|ref|XP_866392.1| QAERKPKPNPNLLFSDVYQEMPTQLRKQQEALARHLQTYGEHYP-LDHFE gi|27806229|ref|NP_776931.1| QAERKLKPNPSLIFSDVYQEMPAQLRKQQESLARHLQTYGEHYP-LDHFE gi|183396774|ref|NP_031559.3| QAERKLKPNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYP-LDHFD gi|77736548|ref|NP_036914.1| QAERKLKPNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYP-LDHFD gi|66773104|ref|NP_001019590.1 RAERRLKPNPDLMFTDVYDEMVPHIAKQKDSMWRHVQQYKEHYP-LDHYE gi|86563355|ref|NP_001033376.1 AAEKRKKAHYHDLFEDVYDELPLRLRRQRDELDAHVAEYKEHYPMLETLQ gi|18415939|ref|NP_568209.1| VAEKTEKPNLQNMFSDVYDVPPSNLREQELLVRQTINSHPQDYP--SDVP gi|115487674|ref|NP_001066324. VAERMPKPPLAELFTDVYDEVPSNLREQERLLRDTIKKHPADYP--ADVH :*: *. :* .** : * : : : .* gi|39943658|ref|XP_361366.1| GGKDSLKP gi|164422564|ref|XP_960181.2| GGKDSLAR gi|21355903|ref|NP_649905.1| K------- gi|158291301|ref|XP_312823.4| Q------- gi|11386135|ref|NP_000700.1| K------- gi|148727347|ref|NP_001092034. K------- gi|297277135|ref|XP_001101959. K------- gi|73947481|ref|XP_866392.1| K------- gi|27806229|ref|NP_776931.1| K------- gi|183396774|ref|NP_031559.3| K------- gi|77736548|ref|NP_036914.1| K------- gi|66773104|ref|NP_001019590.1 K------- gi|86563355|ref|NP_001033376.1 SKP----- gi|18415939|ref|NP_568209.1| L------- gi|115487674|ref|NP_001066324. I-------

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