View source for Structure-based mutation analysis (PKU)

== short task description ==
== Finding the right structure ==
As proposed we searched the [http://www.uniprot.org/uniprot/P00439 UNIProt entry] for our protein and then selected the entry with the highest resolution and the lowest r-Value. In our case this is [http://www.ebi.ac.uk/pdbe-srv/view/entry/1J8U 1J8U] which is the protein in a complex with its cosubstrate [http://en.wikipedia.org/wiki/Tetrahydrobiopterin BH4].
IN the following we will only use this structure, but we also list the results we found.
<figtable id="uniprotresult">
<center><caption>Table with results from UNIProt with r-Value inserted</caption></center>
{| align="center"
!|Entry	
!|Method
!|Resolution (Å)
!|r-Value
!|Chain
!|Positions
!|PDBsum
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1DMW 1DMW]
|X-ray
|2.00
|0.200
|A
|[http://www.uniprot.org/blast/?about=P00439%5B118-424%5D 118-424]
|[[http://www.ebi.ac.uk/pdbsum/1DMW »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1J8T 1J8T]
|X-ray
|1.70
|0.197
|A
|[http://www.uniprot.org/blast/?about=P00439%5B103-427%5D 103-427]
|[[http://www.ebi.ac.uk/pdbsum/1J8T »]]
|-
|style="background-color:yellow;"|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1J8U 1J8U]
|style="background-color:yellow;"|X-ray
|style="background-color:yellow;"|1.50
|style="background-color:yellow;"|0.157
|style="background-color:yellow;"|A
|style="background-color:yellow;"|[http://www.uniprot.org/blast/?about=P00439%5B103-427%5D 103-427]
|style="background-color:yellow;"|[[http://www.ebi.ac.uk/pdbsum/1J8U »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1KW0 1KW0]
|X-ray
|2.50
|0.220
|A
|[http://www.uniprot.org/blast/?about=P00439%5B103-427%5D 103-427]
|[[http://www.ebi.ac.uk/pdbsum/1KW0 »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1LRM 1LRM]
|X-ray
|2.10
|0.211
|A
|[http://www.uniprot.org/blast/?about=P00439%5B103-427%5D 103-427]
|[[http://www.ebi.ac.uk/pdbsum/1LRM »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1MMK 1MMK]
|X-ray
|2.00
|0.199
|A
|[http://www.uniprot.org/blast/?about=P00439%5B103-427%5D 103-427]
|[[http://www.ebi.ac.uk/pdbsum/1MMK »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1MMT 1MMT]
|X-ray
|2.00
|0.213
|A
|[http://www.uniprot.org/blast/?about=P00439%5B103-427%5D 103-427]
|[[http://www.ebi.ac.uk/pdbsum/1MMT »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1PAH 1PAH]
|X-ray
|2.00
|0.176
|A
|[http://www.uniprot.org/blast/?about=P00439%5B117-424%5D 117-424]
|[[http://www.ebi.ac.uk/pdbsum/1PAH »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1TDW 1TDW]
|X-ray
|2.10
|0.206
|A
|[http://www.uniprot.org/blast/?about=P00439%5B117-424%5D 117-424]
|[[http://www.ebi.ac.uk/pdbsum/1TDW »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/1TG2 1TG2]
|X-ray
|2.20
|0.213
|A
|[http://www.uniprot.org/blast/?about=P00439%5B117-424%5D 117-424]
|[[http://www.ebi.ac.uk/pdbsum/1TG2 »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/2PAH 2PAH]
|X-ray
|3.10
|0.251
|A/B
|[http://www.uniprot.org/blast/?about=P00439%5B118-452%5D 118-452]
|[[http://www.ebi.ac.uk/pdbsum/2PAH »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/3PAH 3PAH]
|X-ray
|2.00
|0.175
|A
|[http://www.uniprot.org/blast/?about=P00439%5B117-424%5D 117-424]
|[[http://www.ebi.ac.uk/pdbsum/3PAH »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/4ANP 4ANP]
|X-ray
|2.11
|0.204
|A
|[http://www.uniprot.org/blast/?about=P00439%5B104-427%5D 104-427]
|[[http://www.ebi.ac.uk/pdbsum/4ANP »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/4PAH 4PAH]
|X-ray
|2.00

|0.169
|A
|[http://www.uniprot.org/blast/?about=P00439%5B117-424%5D 117-424]
|[[http://www.ebi.ac.uk/pdbsum/4PAH »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/5PAH 5PAH]
|X-ray
|2.10
|0.163
|A
|[http://www.uniprot.org/blast/?about=P00439%5B117-424%5D 117-424]
|[[http://www.ebi.ac.uk/pdbsum/5PAH »]]
|-
|[http://www.ebi.ac.uk/pdbe-srv/view/entry/6PAH 6PAH]
|X-ray	
|2.15
|0.171
|A
|[http://www.uniprot.org/blast/?about=P00439%5B117-424%5D 117-424]
|[[http://www.ebi.ac.uk/pdbsum/6PAH »]]
|-
|}
</figtable>
In <xr id="uniprotresult"/> there are all results according to which we selected 1J8U to be our reference for this weeks task.